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Clinical Trial Details

Trial ID: L3938
Source ID: NCT00359112
Associated Drug: Metformin
Title: AVANDAMET Versus Metformin And Sulphonylurea In People With Poorly Controlled Type 2 Diabetes
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: Non-Insulin-Dependent Diabetes Mellitus
Interventions: DRUG: metformin|DRUG: sulphonylurea|DRUG: Avandamet
Outcome Measures: Primary: Change in HbA1c level from baseline following 52 weeks of treatment. | Secondary: Change in FPG (fasting plasma glucose)|insulin sensitivity|beta cell function|change in PAI-1|CRP|number of hypoglycaemic events|Change in 24 hr ABPM|Diabetes treatment satisfaction.
Sponsor/Collaborators: Sponsor: GlaxoSmithKline
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 544
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Start Date: 2004-02
Completion Date:
Results First Posted:
Last Update Posted: 2009-05-18
Locations: GSK Investigational Site, Brugge, 8000, Belgium|GSK Investigational Site, Bruxelles, 1030, Belgium|GSK Investigational Site, Bruxelles, 1210, Belgium|GSK Investigational Site, Heverlee, 3001, Belgium|GSK Investigational Site, Landen, 3400, Belgium|GSK Investigational Site, Namur (Champion), 5020, Belgium|GSK Investigational Site, Oostham, 3945, Belgium|GSK Investigational Site, Petit-Rechain, 4800, Belgium|GSK Investigational Site, Tessenderlo, 3980, Belgium|GSK Investigational Site, Tremelo, 3120, Belgium|GSK Investigational Site, Willebroek, 2830, Belgium|GSK Investigational Site, Zandhoven (Pulle), 2243, Belgium|GSK Investigational Site, Roubaix, Nord-Pas-de-Calais, 59100, France|GSK Investigational Site, Anzin, 59410, France|GSK Investigational Site, Briollay, 49125, France|GSK Investigational Site, Commelle Vernay, 42120, France|GSK Investigational Site, Cremeaux, 42260, France|GSK Investigational Site, Evron, 53600, France|GSK Investigational Site, Laval, 53000, France|GSK Investigational Site, Louverne, 53950, France|GSK Investigational Site, Lyon, 69007, France|GSK Investigational Site, Paris, 75015, France|GSK Investigational Site, Roanne, 42300, France|GSK Investigational Site, Saint Ouen, 93400, France|GSK Investigational Site, Sainte Suzanne, 53270, France|GSK Investigational Site, Segré, 49500, France|GSK Investigational Site, Venissieux, 69200, France|GSK Investigational Site, Gueglingen, Baden-Wuerttemberg, 74363, Germany|GSK Investigational Site, Kippenheim, Baden-Wuerttemberg, 77971, Germany|GSK Investigational Site, Koenigsfeld, Baden-Wuerttemberg, 78126, Germany|GSK Investigational Site, Waldshut-Tiengen, Baden-Wuerttemberg, 79961, Germany|GSK Investigational Site, Weinheim, Baden-Wuerttemberg, 69469, Germany|GSK Investigational Site, Grafing, Bayern, 85567, Germany|GSK Investigational Site, Herzogenaurach, Bayern, 91074, Germany|GSK Investigational Site, Immenstadt, Bayern, 87509, Germany|GSK Investigational Site, Oberteisendorf, Bayern, 83317, Germany|GSK Investigational Site, Saaldorf-Surheim, Bayern, 83416, Germany|GSK Investigational Site, Wallerfing, Bayern, 94574, Germany|GSK Investigational Site, Wuerzburg, Bayern, 97072, Germany|GSK Investigational Site, Grossalmerode, Hessen, 37247, Germany|GSK Investigational Site, Einbeck, Niedersachsen, 37574, Germany|GSK Investigational Site, Hannover, Niedersachsen, 30519, Germany|GSK Investigational Site, Isernhagen, Niedersachsen, 30916, Germany|GSK Investigational Site, Papenburg, Niedersachsen, 26871, Germany|GSK Investigational Site, Beckum, Nordrhein-Westfalen, 59269, Germany|GSK Investigational Site, Bergkamen-Rünthe, Nordrhein-Westfalen, 59192, Germany|GSK Investigational Site, Bochum, Nordrhein-Westfalen, 44869, Germany|GSK Investigational Site, Dinslaken, Nordrhein-Westfalen, 46537, Germany|GSK Investigational Site, Dortmund, Nordrhein-Westfalen, 44137, Germany|GSK Investigational Site, Essen, Nordrhein-Westfalen, 45134, Germany|GSK Investigational Site, Essen, Nordrhein-Westfalen, 45359, Germany|GSK Investigational Site, Goch, Nordrhein-Westfalen, 47574, Germany|GSK Investigational Site, Koeln, Nordrhein-Westfalen, 51069, Germany|GSK Investigational Site, Viersen, Nordrhein-Westfalen, 41749, Germany|GSK Investigational Site, Mainz, Rheinland-Pfalz, 55116, Germany|GSK Investigational Site, Neuwied, Rheinland-Pfalz, 56564, Germany|GSK Investigational Site, Rhaunen, Rheinland-Pfalz, 55624, Germany|GSK Investigational Site, Speyer, Rheinland-Pfalz, 67346, Germany|GSK Investigational Site, Saarlouis, Saarland, 66740, Germany|GSK Investigational Site, Wolmirstedt, Sachsen-Anhalt, 39326, Germany|GSK Investigational Site, Dresden, Sachsen, 01219, Germany|GSK Investigational Site, Elmshorn, Schleswig-Holstein, 25335, Germany|GSK Investigational Site, Blanchardstown, 15, Ireland|GSK Investigational Site, Dublin, 8, Ireland|GSK Investigational Site, Dublin, 9, Ireland|GSK Investigational Site, Bologna, Emilia-Romagna, 40138, Italy|GSK Investigational Site, Ferrara, Emilia-Romagna, 44100, Italy|GSK Investigational Site, Ravenna, Emilia-Romagna, 48100, Italy|GSK Investigational Site, Arenzano (GE), Liguria, 16011, Italy|GSK Investigational Site, Genova, Liguria, 16132, Italy|GSK Investigational Site, Sassari, Sardegna, 07100, Italy|GSK Investigational Site, Città di Castello (PG), Umbria, 06012, Italy|GSK Investigational Site, Terni, Umbria, 05100, Italy|GSK Investigational Site, Kaunas, LT-44320, Lithuania|GSK Investigational Site, Kaunas, LT-49335, Lithuania|GSK Investigational Site, Vilnius, LT-07156, Lithuania|GSK Investigational Site, Vilnius, LT-08661, Lithuania|GSK Investigational Site, Tijuana, Baja California Norte, 22320, Mexico|GSK Investigational Site, Pachuca, Hidalgo, 42039, Mexico|GSK Investigational Site, Guadalajara, Jalisco, 44340, Mexico|GSK Investigational Site, Durango, 3400, Mexico|GSK Investigational Site, Mexico, D.F., 11850, Mexico|GSK Investigational Site, Beek En Donk, 5741 CG, Netherlands|GSK Investigational Site, Beerzerveld, 7685 PG, Netherlands|GSK Investigational Site, Den Haag, 2582 LJ, Netherlands|GSK Investigational Site, Heerlen, 6416 EG, Netherlands|GSK Investigational Site, Hoogvliet, 3192 JN, Netherlands|GSK Investigational Site, Landgraaf, 6373 JS, Netherlands|GSK Investigational Site, Musselkanaal, 9581 AJ, Netherlands|GSK Investigational Site, Oude Pekela, 9665 AR, Netherlands|GSK Investigational Site, Spijkenisse, 3207 NB, Netherlands|GSK Investigational Site, Woerden, 3443 GG, Netherlands|GSK Investigational Site, Zaandam, 1504 JA, Netherlands|GSK Investigational Site, Zieuwent, 7136 KH, Netherlands|GSK Investigational Site, Alcobendas/Madrid, 28100, Spain|GSK Investigational Site, Alcora/Castellón, 12110, Spain|GSK Investigational Site, Alicante, Spain|GSK Investigational Site, Alzira, 46600, Spain|GSK Investigational Site, Artana/Castellón, 12527, Spain|GSK Investigational Site, Barcelona, 08015, Spain|GSK Investigational Site, Barcelona, 08022, Spain|GSK Investigational Site, Benicassim (Castellon), Spain|GSK Investigational Site, Cadiz, 11009, Spain|GSK Investigational Site, Castellón, Spain|GSK Investigational Site, Cáceres, 10004, Spain|GSK Investigational Site, Gerona, Spain|GSK Investigational Site, Granada, 18014, Spain|GSK Investigational Site, Madrid, 28034, Spain|GSK Investigational Site, Madrid, 28037, Spain|GSK Investigational Site, Madrid, 28041, Spain|GSK Investigational Site, Madrid, 28046, Spain|GSK Investigational Site, Malaga, 29009, Spain|GSK Investigational Site, Merida, 6800, Spain|GSK Investigational Site, Móstoles/Madrid, 28935, Spain|GSK Investigational Site, Onda (Castellon), Spain|GSK Investigational Site, Pontevedra, 36002, Spain|GSK Investigational Site, Sabadell (Barcelona), 08208, Spain|GSK Investigational Site, San Juan De Alicante, 3550, Spain|GSK Investigational Site, Sta Coloma de Gramanet (Barcelona), 08923, Spain|GSK Investigational Site, Tarrasa, Barcelona, 08221, Spain|GSK Investigational Site, Valencia, 46010, Spain|GSK Investigational Site, Bern, 3007, Switzerland|GSK Investigational Site, Emmenbrücke, 6020, Switzerland|GSK Investigational Site, Gettnau, 6142, Switzerland|GSK Investigational Site, Jegenstorf, 3303, Switzerland|GSK Investigational Site, Lugano, 6900, Switzerland|GSK Investigational Site, Luzern, 6004, Switzerland|GSK Investigational Site, Pregassona, 6963, Switzerland|GSK Investigational Site, Salmsach, 8599, Switzerland|GSK Investigational Site, St. Maurice, 1890, Switzerland|GSK Investigational Site, Steckborn, 8266, Switzerland|GSK Investigational Site, Winterthur, 8400, Switzerland|GSK Investigational Site, Winterthur, 8405, Switzerland|GSK Investigational Site, Zürich, 8046, Switzerland|GSK Investigational Site, Zürich, 8050, Switzerland|GSK Investigational Site, Glasgow, Lanarkshire, G3 8YJ, United Kingdom|GSK Investigational Site, Glasgow, Lanarkshire, G69 7AD, United Kingdom|GSK Investigational Site, Blackpool, Lancashire, FY4 3AD, United Kingdom|GSK Investigational Site, Bath, Somerset, BA1 3NG, United Kingdom|GSK Investigational Site, Bristol, BS2 8HW, United Kingdom|GSK Investigational Site, Leeds, LS12 1JE, United Kingdom|GSK Investigational Site, Sheffield, S5 7AU, United Kingdom
URL: https://clinicaltrials.gov/show/NCT00359112

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D089 Metformin small molecule DB00331 Details
D116 Rosiglitazone small molecule DB00412 Details