| Outcome Measures: |
Primary: Pharmacokinetics parameters of SHR3824 and Metformin in the fasted and fed state: Cmax, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 and Metformin in the fasted and fed state: AUC0-t, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 and Metformin in the fasted and fed state: AUC0-inf (if applicable), Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8 | Secondary: Pharmacokinetics parameters of SHR3824 and Metformin in the fasted and fed state: Tmax, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 and Metformin in the fasted and fed state: Vz/F, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 and Metformin in the fasted and fed state: CL/F, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 and Metformin in the fasted and fed state: t1/2, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 and Metformin after single and multiple dose: Tmax, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 and Metformin after single and multiple dose: Ctrough, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 and Metformin after single and multiple dose: Racc etc, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8|The incidence and severity of adverse events/serious adverse events, Based on pre-dose, 0.5-72 hours post-dose sampling times on Day 1 and Day 8
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