| Outcome Measures: |
Primary: Hemoglobin A1c (HbA1c), Hemoglobin is a protein within red blood cells. As glucose enters the bloodstream, it binds to hemoglobin, or glycates. The more glucose that enters the bloodstream, the higher the amount of glycated hemoglobin. An HbA1C level below 5.7 percent is considered normal. Reported as percentage of glycated hemoglobin, Baseline to 24 weeks|Area under curve (AUC) for glucose, Pre-post study difference in AUC for glucose, Baseline to 24 weeks|AUC for C-peptide, Pre-post study difference in AUC for C-Peptide, Baseline to 24 weeks|AUC for Insulin, Pre-post study difference in AUC for Insulin, Baseline to 24 weeks|AUC for glucagon, Pre-post study difference in AUC for glucagon, Baseline to 24 weeks | Secondary: Fasting plasma glucose, Pre-post study difference in Fasting plasma glucose, Baseline to 24 weeks|Lean mass, Pre-post study difference in lean mass, Baseline to 24 weeks|Fat mass, Pre-post study difference in fat mass, Baseline to 24 weeks|Visceral fat, Pre-post study difference in visceral fat, Baseline to 24 weeks|Fecal elastase, Pre-post study difference in Fecal elastase (ELISA quantitative test, normal \>200 mcg/g), Baseline to 24 weeks|High Sensitivity C-Reactive Protein (Hs-CRP), Pre-post study difference in Hs-CRP, Baseline to 24 weeks|Total cholesterol, LDL, HDL and Triglyceride, Pre-post study difference in Total cholesterol, LDL, HDL and Triglyceride, Baseline to 24 weeks|β-Hydroxybutyrate, Pre-post study difference in β-Hydroxybutyrate, Baseline to 24 weeks|Body weight, Pre-post study difference in body weight, Baseline to 24 weeks|Blood Pressure, Pre-post study difference in Blood Pressure, Baseline to 24 weeks|Body Mass Index (BMI), Pre-post study difference in BMI, Baseline to 24 weeks|Patient-Reported Outcomes Measurement Information System - 29 Profile v2.1 (PROMIS-29 Profile v2.1), The PROMIS-29 Profile assesses following domains: * Physical function * Pain interference * Anxiety * Depression * Fatigue * Sleep disturbance * Ability to participate in social roles and activities PROMIS-29 is scored using T-scores. Higher T-scores indicate a higher level of the underlying construct. Each domain has a set of questions, typically 4 to 6 items, and responses are rated on a 5-point Likert scale (e.g., "Never," "Rarely," "Sometimes," "Often," "Always" or "Not at all," "A little bit," "Somewhat," etc.). The responses are then scored on a T-score scale (with a mean of 50 and a standard deviation of 10 in the general population). T-scores Interpretation: * A T-score of 50 is the average score for the general population. * T-scores above 50 indicate better functioning or less severe symptoms. * T-scores below 50 indicate worse functioning or more severe symptoms., Baseline to 24 weeks|Insulin sensitivity, Change in sensitivity from baseline vs 24 weeks (Homeostatic Model Assessment, Matsuda Index), Baseline to 24 weeks|Beta cell function, Change in Beta cell function from baseline vs 24 weeks using oral disposition index, Baseline to 24 weeks | Other: Ketosis, Percentage of participants experiencing Ketosis based on meter data, Baseline to 24 weeks|Diabetic Ketoacidosis (DKA) events, Number of DKA events, Baseline to 24 weeks|Insulin needs, Percentage of participants experiencing requirement for insulin, Baseline to 24 weeks|Chronic pancreatitis exacerbation, Percentage of participants experiencing CP exacerbation, Baseline to 24 weeks|Acute pancreatitis episodes, Percentage of participants experiencing AP episodes, Baseline to 24 weeks|Exocrine pancreatic insufficiency, Percentage of participants experiencing incident exocrine pancreatic insufficiency, Baseline to 24 weeks|Vitamin D, Decrease in vitamin D, Baseline to 24 weeks|Bone fractures, Percentage of participants experiencing bone fractures, Baseline to 24 weeks|Adverse events, Adverse events: Anemia, edema, urinary tract infection, Vaginal yeast infection, Baseline to 24 weeks
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