| Outcome Measures: |
Primary: Change in HbA1c From Baseline to Week 26 (Main Study), The table below shows the least-squares (LS) mean change in HbA1c from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean change., Day 1 (Baseline) and Week 26|Change in HbA1c From Baseline to Week 26 (High Glycemic Substudy), The table below shows the least-squares (LS) mean change in HbA1c from Baseline to Week 26 for each treatment group in patients randomized to the High Glycemic Substudy., Day 1 (Baseline) and Week 26 | Secondary: Percentage of Patients With HbA1c <7% at Week 26 (Main Study), The table below shows the percentage of patients with HbA1c \<7% at Week 26. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the percentage., Week 26|Change in Fasting Plasma Glucose (FPG) From Baseline to Week 26 (Main Study), The table below shows the least-squares (LS) mean change in FPG from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean change., Day 1 (Baseline) and Week 26|Change in 2-hour Post-prandial Glucose From Baseline to Week 26 (Main Study), The table below shows the least-squares (LS) mean change in 2-hour post-prandial glucose from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean change., Day 1 (Baseline) and Week 26|Percent Change in Body Weight From Baseline to Week 26 (Main Study), The table below shows the least-squares (LS) mean percent change in body weight from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean percent change., Day 1 (Baseline) and Week 26|Change in Systolic Blood Pressure (SBP) From Baseline to Week 26 (Main Study), The table below shows the least-squares (LS) mean change in SBP from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean change., Day 1 (Baseline) and Week 26|Percent Change in Triglycerides From Baseline to Week 26 (Main Study), The table below shows the least-squares (LS) mean percent change in triglycerides from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean percent change., Day 1 (Baseline) and Week 26|Percent Change in High-density Lipoprotein Cholesterol (HDL-C) From Baseline to Week 26 (Main Study), The table below shows the least-squares (LS) mean percent change in HDL-C from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean percent change., Day 1 (Baseline) and Week 26|Percentage of Patients With HbA1c <7% at Week 26 (High Glycemic Substudy), The table below shows the percentage of patients with HbA1c \<7% at Week 26 for each treatment group in patients randomized to the High Glycemic Substudy., Week 26|Change in Fasting Plasma Glucose (FPG) From Baseline to Week 26 (High Glycemic Substudy), The table below shows the least-squares (LS) mean change in FPG from Baseline to Week 26 for each treatment group in patients randomized to the High Glycemic Substudy., Day 1 (Baseline) and Week 26|Change in 2-hour Post-prandial Glucose From Baseline to Week 26 (High Glycemic Substudy), The table below shows the least-squares (LS) mean change in 2-hour post-prandial glucose from Baseline to Week 26 for each treatment group in patients randomized to the High Glycemic Substudy., Day 1 (Baseline) and Week 26|Percent Change in Body Weight From Baseline to Week 26 (High Glycemic Substudy), The table below shows the least-squares (LS) mean percent change in body weight from Baseline to Week 26 for each treatment group in patients randomized to the High Glycemic Substudy., Day 1 (Baseline) and Week 26|Change in Systolic Blood Pressure (SBP) From Baseline to Week 26 (High Glycemic Substudy), The table below shows the least-squares (LS) mean change in SBP from Baseline to Week 26 for each treatment group in patients randomized to the High Glycemic Substudy., Day 1 (Baseline) and Week 26|Percent Change in Triglycerides From Baseline to Week 26 (High Glycemic Substudy), The table below shows the least-squares mean percent change in triglycerides from Baseline to Week 26 for each treatment group in patients randomized to the High Glycemic Substudy., Day 1 (Baseline) and Week 26|Percent Change in High-density Lipoprotein Cholesterol (HDL-C) From Baseline to Week 26 (High Glycemic Substudy), The table below shows the least-squares mean percent change in HDL-C from Baseline to Week 26 for each treatment group in patients randomized to the High Glycemic Substudy., Day 1 (Baseline) and Week 26
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| Locations: |
Phoenix, Arizona, United States|Concord, California, United States|Greenbrae, California, United States|Los Angeles, California, United States|Spring Valley, California, United States|Colorado Springs, Colorado, United States|Denver, Colorado, United States|Northglenn, Colorado, United States|Springfield, Illinois, United States|Evansville, Indiana, United States|Baton Rouge, Louisiana, United States|Metairie, Louisiana, United States|Meridian, New Jersey, United States|Albuquerque, New Mexico, United States|New York, New York, United States|West Seneca, New York, United States|Mooresville, North Carolina, United States|Perryopolis, Pennsylvania, United States|Pittsburgh, Pennsylvania, United States|Taylors, South Carolina, United States|Dallas, Texas, United States|Houston, Texas, United States|San Antonio, Texas, United States|Norfolk, Virginia, United States|Horn, Austria|Salzburg, Austria|Wien, Austria|Barranquilla, Colombia|Bogota, Colombia|Pärnu, Estonia|Tartu, Estonia|Viljandi, Estonia|Guatemala, Guatemala|Reykjavik, Iceland|Bangalore, India|Hyderabad, India|Nagpur, India|Busan, Korea, Republic of|Goyang-Si, Korea, Republic of|Jeonju-Si, Korea, Republic of|Seoul, Korea, Republic of|Wonju-Si, Korea, Republic of|Kaunas, Lithuania|Klaipeda, Lithuania|Siauliai, Lithuania|Vilnius Lt, Lithuania|Vilnius, Lithuania|Kelantan, Malaysia|Kuala Lumpur N/A, Malaysia|Kuala Lumpur, Malaysia|Aguascalientes, Mexico|Guadalajara, Mexico|Mex, Mexico|Monterrey, Mexico|Zapopan, Mexico|Makati, Philippines|Manila, Philippines|Marikina City, Philippines|Pasay, Philippines|Katowice, Poland|Torun, Poland|Warszawa, Poland|Fajardo, Puerto Rico|Ponce, Puerto Rico|San Juan, Puerto Rico|Baia Mare, Romania|Brasov, Romania|Bucharest, Romania|Targu Mures, Romania|Halfway, South Africa|Pretoria, South Africa|Alcala De Henares, Spain|Elche, Spain|Girona, Spain|Pozuelo De Alarcon, Spain|Göteborg, Sweden|Lund, Sweden|Malmö, Sweden|Skene, Sweden
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