| Outcome Measures: |
Primary: haemoglobin A1c(HbA1c), Absolute changes from baseline in HbA1c at week 16., From baseline to 16 week. | Secondary: Weight loss, The proportion of weight loss from baseline to week 16；the proportion of subjects who loss 5% weight at week 16 compares baseline., From baseline to 16 week.|GLucose, Absolute changes from baseline in fasting glucose and postprandial glucose at week 16., From baseline to 16 week.|Body Mass Index(BMI), Absolute changes from baseline in BMI in at week 16, body mass index (BMI) was calculated as the body weight (kg)/height (m)2., From baseline to 16 week.|Waistline, Absolute changes from baseline in waistline at week 16., From baseline to 16 week.|Hipline, Absolute changes from baseline in hipline at week 16., From baseline to 16 week.|Serum total cholesterol, Absolute changes from baseline in serum total cholesterol at week 16., From baseline to 16 week.|Serum triglycerides, Absolute changes from baseline in triglycerides at week 16., From baseline to 16 week.|Serum Low Density Lipoprotein-Cholesterol(LDL-C), Absolute changes from baseline in LDL-C at week 16., From baseline to 16 week.|Serum High Density Lipoprotein-Cholesterol(HDL-C), Absolute changes from baseline in HDL-C at week 16., From baseline to 16 week.|Adipose tissue of liver, Absolute changes from baseline in HDL-C at week 16, adipose tissue of liver will be mersured by Fibroscan, a device useing an ultrasound transducer probe to vibrations of liver presenting adipose tissue content., From baseline to 16 week.|Homeostasis model assessment for insulin resistance(HOMA-IR), Absolute changes from baseline in HOMA-IR at week 16, HOMA-IR was calculated as \[fasting glucose (mmol/L)× fasting insulin (μU/ml)/22.5\]., From baseline to 16 week.|Homeostasis model assessment for β cell(HOMA-β), Absolute changes from baseline in HOMA-β at week 16, HOMA-β was calculated as \[20× fasting insulin (μU/ml)/fasting glucose (mmol/L)-3.5\]., From baseline to 16 week.
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| Locations: |
Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China|The First Affiliated Hospital of Harbin Medical University, Ha'erbin, Heilongjiang, China|The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China|The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China
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