| Outcome Measures: |
Primary: Effective renal plasma flow (ERPF), Measured by PAH clearance, 4 hours|Glomerular filtration rate (GFR), Measured by iohexol clearance, 4 hours | Secondary: Insulin sensitivity, Measured by hyperinsulinemic-euglycemic clamp, 4 hours|Renal oxygenation, Blood oxygen level dependent (BOLD) MRI, 60 min|Renal perfusion, Arterial spin labeling (ASL) MRI, 10 min | Other: Podocyte numerical density and number per glomerulus, Measured by light microscopy from tissue obtained by renal biopsy, 4 hours|Foot process width of glomeruli, Measured by electron microscopy from tissue obtained by renal biopsy, 4 hours|Detachment and endothelial fenestration of glomeruli, Measured by electron microscopy from tissue obtained by renal biopsy, 4 hours|Podocyte volume of glomeruli, Measured by electron microscopy from tissue obtained by renal biopsy, 4 hours|Number and identity of RNA in kidney cells, Measured from tissue obtained by renal biopsy, 4 hours|Epigenetic profiling, Measured from tissue obtained by renal biopsy, 4 hours
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