| Trial ID: | L4718 |
| Source ID: | NCT00656864
|
| Associated Drug: |
Pioglitazone
|
| Title: |
Pioglitazone Incretin Study
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Diabetes Mellitus, Type 2
|
| Interventions: |
DRUG: Pioglitazone|DRUG: Placebo
|
| Outcome Measures: |
Primary: Change in incretin-mediated insulin secretion and receptor regulation of glucose-dependent insulinotropic peptide (GIP) in patients with type 2 diabetes., 12 weeks per subject | Secondary: Change in active GIP in response to an oral glucose tolerance test and mixed meal challenge, 12 weeks|Change in active GLP-1 in response to the oral glucose tolerance test and the mixed meal challenge, 12 weeks|Change in glucose response during the oral glucose tolerance test and mixed meal challenge, 12 weeks|Change in insulin secretion during the oral glucose tolerance test and the mixed meal challenge, 12 weeks|Change in the acute insulin response to glucose, insulin sensitivity and the disposition index during the IV glucose tolerance test., 12 weeks|Change in adipocyte GIP receptor mRNA expression levels., 12 weeks
|
| Sponsor/Collaborators: |
Sponsor: University of Vermont | Collaborators: Takeda
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
24
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2008-05
|
| Completion Date: |
2010-11
|
| Results First Posted: |
|
| Last Update Posted: |
2011-02-02
|
| Locations: |
University of Vermont, South Burlington, Vermont, 05403, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT00656864
|
