| Trial ID: | L0479 |
| Source ID: | NCT05171686
|
| Associated Drug: |
Diuretic Augmentation (Hydrochlorothiazide, Chlorthalidone, Furosemide, Torsemide, Or Bumetanide)
|
| Title: |
Diuretics and Volume Overload in Early CKD
|
| Acronym: |
DOCK
|
| Status: |
RECRUITING
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Chronic Kidney Disease|Hypertension
|
| Interventions: |
DRUG: Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)
|
| Outcome Measures: |
Primary: Change in NT-pro-BNP, Change in NT-pro-BNP from baseline to 4 weeks after intervention, 4 weeks | Secondary: Change in BNP, Change in BNP from baseline to 4 weeks after intervention, 4 weeks|Change in FACIT-F score, Change in fatigue as measured by FACIT-F score from baseline to 4 weeks after intervention, 4 weeks|Change in QIDS-SR16, Change in depression as measured by the QIDS-SR16 from baseline to 4 weeks after intervention, 4 weeks|Change in KDQOL, Change in quality of life as measured by the KDQOL from baseline to 4 weeks after intervention, 4 weeks|Change in total peripheral resistance index, Change in total peripheral resistance index from baseline to 4 weeks after intervention, 4 weeks|Change in systolic blood pressure, Change in systolic blood pressure from baseline to 4 weeks after intervention, 4 weeks|Change in diastolic blood pressure, Change in diastolic blood pressure from baseline to 4 weeks after intervention, 4 weeks|Change in mean arterial pressure, Change in mean arterial pressure from baseline to 4 weeks after intervention, 4 weeks|Change in pulse pressure, Change in pulse pressure from baseline to 4 weeks after intervention, 4 weeks|Change in cardiac index, Change in cardiac index from baseline to 4 weeks after intervention, 4 weeks|Change in extracellular volume normalized/total body weight, Change in extracellular volume normalized to total body weight from baseline to 4 weeks after intervention, 4 weeks
|
| Sponsor/Collaborators: |
Sponsor: VA Office of Research and Development
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
46
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
|
| Start Date: |
2023-02-01
|
| Completion Date: |
2025-07-01
|
| Results First Posted: |
|
| Last Update Posted: |
2024-12-09
|
| Locations: |
Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas, 77030-4211, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT05171686
|
