| Trial ID: | L0484 |
| Source ID: | NCT00722215
|
| Associated Drug: |
Bq-123 (Selective Endothelin A Receptor Antagonist)
|
| Title: |
Endothelin Receptor Antagonism in Proteinuric Nephropathy
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Chronic Kidney Disease|Proteinuria
|
| Interventions: |
DRUG: BQ-123 (selective endothelin A receptor antagonist)|DRUG: 0.9 % saline|DRUG: Nifedipine
|
| Outcome Measures: |
Primary: Proteinuria, Acute change in proteinuria over 4 hour period following BQ-123 dosing|Blood pressure, Acute change in blood pressure over 4 hour period following BQ-123 dosing | Secondary: Arterial stiffness (as measured by pulse wave velocity), Acute change in arterial stiffness over 4 hour period following BQ-123 dosing|Endothelial function (as measured by flow-mediated dilatation), Acute change in endothelial function over 4 hour period following BQ-123 dosing
|
| Sponsor/Collaborators: |
Sponsor: University of Edinburgh | Collaborators: British Heart Foundation
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE1
|
| Enrollment: |
22
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2006-05
|
| Completion Date: |
2007-12
|
| Results First Posted: |
|
| Last Update Posted: |
2008-07-25
|
| Locations: |
Clinical Research Centre, Western General Hospital, Edinburgh, Scotland, EH4 2XU, United Kingdom
|
| URL: |
https://clinicaltrials.gov/show/NCT00722215
|
