| Outcome Measures: |
Primary: Death, The cause of death was determined by attending doctor or was assessed by interviewing the family., Duration varied between individual patients and was as the period of time after treatment with incretin-based therapy combined with insulin. | Secondary: HbA1c, Duration varied between individual patients and was as the period of time until after treatment with incretin-based therapy combined with insulin., Average time requires 5 years|BMI, BMI was calculated from body weight and height for at baseline and every 3 to 6 months throughout the study., Average time requires 5 years|Blood pressure, Participants were examined using the same methods reported previously (4). Briefly, BP was measured in the clinic and at home on waking in the morning at trough by the same methods included device, device validation, observer, number of measurements, conditions, posture and cuffs described previously (4). Namely, clinic BP (CBP) was measured once in each clinic visit. Home BP (HBP) was measured every day in the morning within 10 minutes after awakening in the sitting position., Average time requires 5 years|Insulin dose, Patients were treated with insulin analogues using MDI, or twice-daily injections. The dose was estimated by medical records., Average time requires 5 years|Hypoglycemia, Patients were treated with insulin analogues using MDI, or twice-daily injections. The dose was estimated by medical records., Average time requires 5 yearsinsulin.|Hypoglycemia, Hypoglycemia and the number of time per day were assessed by medical examination owing to interview., Average time requires 5 years|Microvascular complications including renal anemia, They were assessment by the method mentioned above. As renal anemia, serum hemoglobin (Hb) was measured by cyanmet-hemoglobin method using commercial reagent., Average time requires 5 years|Macrovasular complications, They were confirmed by medical history, including contents of treatment. New or worsened (recurrent) events were defined based on clinical manifestations and treatment throughout the study., Average time requires 5 years
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