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Clinical Trial Details

Trial ID: L4934
Source ID: NCT04126603
Associated Drug: Semaglutide
Title: Impact of Semaglutide on CD34+ EPC and Fat Derived MSC
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Placebos
Outcome Measures: Primary: CD34+ Endothelial Progenitor Cell number, Number of CD34+ EPCs. at % of total Mononuclear cells., 24 Weeks|CD34+ Endothelial Progenitor Cell Migration against serum SDF1a gradient, how far the CD34+ migrates in response to SDF1a, 24 Weeks|Gene Expression of CD34+ Endothelial Progenitor Cell number, we will evaluate mRNA gene expression of endothelial Progenitor cell IL-6, IL1β, TNF-alpha, COX2, endothelin 1, p53, p21, and caspase, 24 Weeks | Secondary: Gene Expression of Subcutaneous Adipose cell, We will evaluate mRNA gene expression for mature fat and fat related transcription factors., 24 Weeks|Arterial Stiffness: Pulse Wave Velocity, Velocity of pulse travelling throughout the Body in m/s, 24 Weeks|Arterial Stiffness: Pulse Wave Analysis, Augmentation Index calculated of ratio of reflected waveform from the end arterioles, 24 Weeks|Body Composition: BMI, Body mass index measured using Bio metric Impedance Scale, 24 Weeks|Body Composition: Body Fat Percent, Percent of Body Fat measured using Bio metric Impedance Scale, 24 Weeks|Hip to Waist Ratio, Ratio of Hip to Waist, 24 Weeks|Biochemistry: HbA1c, hemoglobin percent, 24 Weeks|Biochemistry: LDL over HDl Ratio, ratio of LDL over HDL, 24 Weeks
Sponsor/Collaborators: Sponsor: Sabyasachi Sen
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 38
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2019-08-01
Completion Date: 2023-10-25
Results First Posted:
Last Update Posted: 2024-04-26
Locations: The GW Medical Faculty Associates, Washington, District of Columbia, 20037, United States|Washington VA Medical Center, Washington, District of Columbia, 20422, United States
URL: https://clinicaltrials.gov/show/NCT04126603