| Outcome Measures: |
Primary: Rb-82 PET, Between group difference in the change in myocardial flow reserve (MFR) by Rb-82 PET. Measured as change in global perfusion from rest to adenosine-induced stress., 13 weeks|Invasive hemodynamics, Substudy, performed on 38 participants from the main group. Using right heart catheterisation to measure between group difference in the change in pulmonary capillary weight pressure (PCWP) at 25 watts (supine bicycle ergometer), 13 weeks | Secondary: Echocardiography, Between group difference in the change in global left ventricular function assessed by echocardiography, 13 weeks|GFR, Between group difference in the change in renal function assessed by Cr-51 EDTA, 13 weeks|U-alb/crea, Between group difference in the change urinary albumin/creatinine ratio, 13 weeks|24 hour BP, Between group difference in the change in 24 hour BP, 13 weeks|Pulse wave analysis, Between group difference in the change in pulse wave analysis, 13 weeks|Insulin resistance, Between group difference in the changes in insulin resistance by Matsuda index, 13 weeks|Insulin resistance, Between group difference in the changes in insulin resistance by HOMA, 13 weeks|Biomarkers, Between group difference in the change in NT-proBNP, MR-proANP, MR-proADM, GAL-3, hsTNT, GDF-15, PIGF, sFlt-1, FFA, ADPN, leptin, TNF-α, IL-6, MCP-1, MAC-1, COLL-A1, FGF-21, beta-hydroxybutyrate, AGEs CML, sRAGE, 13 weeks|Questionnaires, Between group difference in the change in Health status, assessed by the EuroQol EQ-5D-5L questionnaire, 13 weeks|Questionnaires, continued, Between group difference in the change in Health status, assessed by the Minnesota Living with Heart Failure questionnaire, 13 weeks|DEXA, Between group difference in the change in body composition by DEXA scan, 13 weeks|Invasive hemodynamics - continued, Between group difference in the change in CO at rest, 25 watts and peak exercise, 13 weeks|Invasive hemodynamics - continued, Between group difference in the change in CVP at rest, 25 watts and peak exercise, 13 weeks|Invasive hemodynamics - continued, Between group difference in the change in PCWP at rest, 25 watts and peak exercise, 13 weeks|Invasive hemodynamics - continued, Between group difference in the change in PAP at rest, 25 watts and peak exercise, 13 weeks|Invasive hemodynamics - continued, Between group difference in the change in SvO2 at rest, 25 watts and peak exercise, 13 weeks|Adipose tissue, Between group difference in the changes in levels of adipocyte differentiation, 13 weeks|Adipose tissue, Between group difference in the changes in macrophage infiltration, 13 weeks|Adipose tissue, Between group difference in the changes in extracellular matrix fibrosis, 13 weeks|Daily activity, Between group difference in the change in daily activity levels measured by patient-worn accelerometers., 13 weeks
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