| Outcome Measures: |
Primary: Percent Change in Fractional Excretion of Sodium (FENA), FENA at 3Hrs post-study drug administration after 1 month compared to FENA at 3Hrs post-study drug administration after 1 dose expressed as percent change, sitagliptin vs. placebo, 3 Hrs post-administration after 1 month and after 1 dose | Secondary: Change in Glomerular Filtration Rate (GFR), Measured GFR (Inulin Clearance) at 3Hrs post study-drug after 1 month compared to Measured GFR at 3Hrs post-study drug after 1 dose, sitagliptin vs. placebo, 3 Hrs post-administration after 1 month and after 1 dose|Change in Fractional Excretion of Lithium (FELi), FELi at 3 Hr post-study drug administration after 1 month compared to FELI at 3hrs post-study drug administration after 1 dose, sitagliptin vs. placebo, 3 Hrs post-administration after 1 month and after 1 dose|Change From Baseline in SDF-1alpha^1-67 (Intact) Measured by Immunoaffinity and Tandem Mass Spectrometry, Plasma concentration of SDF-1alpha\^1-67 (intact) measured by quantitative mass spectrometry methods after antibody-based affinity enrichment, sitagliptin vs. placebo, 3 Hr vs. baseline after 1 dose|Change From Baseline in SDF-1alpha^3-67 (Truncated) Measured by Tandem Mass Spectrometry With Antibody-based Affinity Enrichment, Plasma concentration of SDF-1alpha\^3-67 (intact) measured by quantitative mass spectrometry methods after antibody-based affinity enrichment, sitagliptin vs. placebo, 3Hrs vs baseline after 1 dose|Change in Systolic Blood Pressure (SBP), Non-invasive Cardiac Output Monitoring, SBP by Non-Invasive cardiac output monitoring at 3Hrs post- study drug administration after 1 month compared to SBP by Non-invasive cardiac output monitoring at 3Hrs after 1 dose, sitagliptin vs placebo, 3 Hrs post-administration after 1 month and after 1 dose|Change in Effective Renal Plasma Flow (ERPF), ERPF (para-aminohippurate clearance) 3Hrs post-study drug administration after 1 month compared to ERPF at 3Hhrs post-study drug administration after 1 dose, sitagliptin vs placebo, 3 Hrs post-administration after 1 month and after 1 dose
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