Clinical Trial Details
| Trial ID: | L5041 |
| Source ID: | NCT01046721 |
| Associated Drug: | Exenatide |
| Title: | Study Looking at Cardiovascular Effects of Exenatide, Its Blood Pressure Lowering Effect and Its Mechanisms |
| Acronym: | |
| Status: | COMPLETED |
| Study Results: | NO |
| Results: | |
| Conditions: | Type 2 Diabetes |
| Interventions: | DRUG: Exenatide|DRUG: Saline |
| Outcome Measures: | Primary: superior mesenteric (SMA) blood flow, Meal induced changes in superior mesenteric (SMA) blood flow - exenatide versus placebo., 0, 30, 60, 90, 120, 150, & 180 min after meal | Secondary: Blood Pressure (BP), BP responses when fasted and after eating- Exenatide vs. placebo., 0, 30, 60, 90, 120, 150, & 180 min after meal|Heart Rate (HR), HR responses when fasted and after eating- Exenatide vs. placebo., 0, 30, 60, 90, 120, 150, & 180 min after meal|Limb Blood Flow (LBF), Limb Blood Flow responses when fasted and after eating- Exenatide vs. placebo., 0, 30, 60, 90, 120, 150, & 180 min after meal|Skin Blood Flow, Skin Blood Flow responses when fasted and after eating- Exenatide vs. placebo., 0, 30, 60, 90, 120, 150, & 180 min after meal|Peripheral resistance, peripheral resistance responses when fasted and after eating- Exenatide vs. placebo., 0, 30, 60, 90, 120, 150, & 180 min after meal |
| Sponsor/Collaborators: | Sponsor: University of Nottingham |
| Gender: | MALE |
| Age: | ADULT |
| Phases: | |
| Enrollment: | 8 |
| Study Type: | INTERVENTIONAL |
| Study Designs: | Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE |
| Start Date: | 2009-09 |
| Completion Date: | 2012-12 |
| Results First Posted: | |
| Last Update Posted: | 2018-03-06 |
| Locations: | David Greenfield Human Physiology Laboratories, Nottingham, Notts, NG72UH, United Kingdom |
| URL: | https://clinicaltrials.gov/show/NCT01046721 |
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