| Outcome Measures: |
Primary: Changes in coronary artery, aortic valve, mitral annulus calcium scores, Vascular and valvular calcium scores, over 24 months | Secondary: Changes in aortic pulse wave velocity, arterial stiffness parameter, over 24 months|annualized percentage change in Coronary artery calcium score, annualized percentage change in calcium score, over 12 months|Changess in serum T50, serum calcification propensity measure, over 24 months|Changes in serum calcium, phosphate, biochemical parameters, over 24 months|Changes in alkaline phosphatase, biochemical parameters, over 24 months|Changes in intact parathyroid hormone, biochemical parameters, over 24 months|Changes in low density lipoprotein-cholesterol, biochemical parameters, over 24 months|Changes in C-reactive protein, biochemical parameters, over 24 months|Changes in systolic blood pressure, blood pressure, over 24 months|Changes in diastolic blood pressure, blood pressure, over 24 months|Changes in Forearm, femur and spine bone mineral density, T score and Z score, Bone mineral density related parameters, over 24 months
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