| Outcome Measures: |
Primary: Steady-state Plasma Glucose (SSPG), Insulin sensitivity measured by SSPG concentration (mg/dL) during the insulin suppression test., baseline, week 9 or 10|Insulin Secretion Rate Area Under the Curve (ISR-AUC), Insulin secretion measured by ISR-AUC (pmol/min x 4 h) during the graded glucose infusion test., baseline, week 9 or 10 | Secondary: Fasting Plasma Glucose, Baseline and end-of-treatment fasting plasma glucose (mg/dL) values represent average of up to 3 measurements for each value (obtained at baseline weeks -2, -1, and 0 and at the end of study at weeks 8, 9, and 10)., 10 weeks|Fasting Plasma Insulin, Baseline and end-of-treatment fasting plasma insulin (mU/L) values represent average of up to 3 measurements for each value (obtained at baseline weeks -2, -1, and 0 and at the end of study at weeks 8, 9, and 10)., 10 weeks|OGTT Glucose AUC, Glucose area under the curve (AUC) (mg/dL x 2 h) measured during a 75-gram oral glucose tolerance test (OGTT)., baseline, week 8|OGTT Insulin AUC, Insulin area under the curve (AUC) (mU/L x 2h) measured during a 75-gram oral glucose tolerance test (OGTT)., baseline, week 8
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