| Outcome Measures: |
Primary: Change in HbA1c From Baseline to Week 26, The table below shows the least-squares (LS) mean change in HbA1c from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean change., Day 1 (Baseline) and Week 26 | Secondary: Percentage of Patients With HbA1c <7% at Week 26, The table below shows the percentage of patients with HbA1c\<7% at Week 26 in each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the percentage., Week 26|Change in Fasting Plasma Glucose (FPG) From Baseline to Week 26, The table below shows the least-squares (LS) mean change in FPG from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean change., Day 1 (Baseline) and Week 26|Change in Homeostasis Model Assessment (HOMA2-%B) From Baseline to Week 26, HOMA2-%B is a measure of beta cell function (the cells in the pancreas that produce and store insulin). The table below shows the least-squares (LS) mean change in HOMA2-%B from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean change., Day 1 (Baseline) and Week 26|Percent Change in Body Weight From Baseline to Week 26, The table below shows the least-squares (LS) mean percent change in body weight from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean percent change., Day 1 (Baseline) and Week 26|Change in Systolic Blood Pressure (SBP) From Baseline to Week 26, The table below shows the least-squares (LS) mean change in SBP from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean change., Day 1 (Baseline) and Week 26|Percent Change in Triglycerides From Baseline to Week 26, The table below shows the least-squares (LS) mean percent change in triglycerides from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean percent change., Day 1 (Baseline) and Week 26|Percent Change in High-density Lipoprotein Cholesterol (HDL-C) From Baseline to Week 26, The table below shows the least-squares (LS) mean percent change in HDL-C from Baseline to Week 26 for each treatment group. The statistical analyses show the treatment differences (ie, each canagliflozin group minus placebo) in the LS mean percent change., Day 1 (Baseline) and Week 26
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| Locations: |
Anniston, Alabama, United States|Phoenix, Arizona, United States|Tucson, Arizona, United States|Little Rock, Arkansas, United States|Burlingame, California, United States|Encinitas, California, United States|Fullerton, California, United States|Roseville, California, United States|Santa Ana, California, United States|Wes Hills, California, United States|Colorado Springs, Colorado, United States|Bartow, Florida, United States|Hollywood, Florida, United States|Jacksonville, Florida, United States|Pembroke Pines, Florida, United States|Des Moines, Iowa, United States|Baton Rouge, Louisiana, United States|Chaska, Minnesota, United States|Picayune, Mississippi, United States|Billings, Montana, United States|Charlotte, North Carolina, United States|Hickory, North Carolina, United States|Raleigh, North Carolina, United States|Dublin, Ohio, United States|Perrysburg, Ohio, United States|Tulsa, Oklahoma, United States|Yukon, Oklahoma, United States|Bensalem, Pennsylvania, United States|Bristol, Tennessee, United States|Kingsport, Tennessee, United States|Nashville, Tennessee, United States|Arlington, Texas, United States|Dallas, Texas, United States|Grand Prairie, Texas, United States|Houston, Texas, United States|New Braunfels, Texas, United States|San Antonio, Texas, United States|Falls Church, Virginia, United States|Virginia Beach, Virginia, United States|Federal Way, Washington, United States|Selah, Washington, United States|Bathurst, New Brunswick, Canada|Moncton, New Brunswick, Canada|Grand Falls-Windsor, Newfoundland and Labrador, Canada|Brampton, Ontario, Canada|Hamilton, Ontario, Canada|Ottawa, Ontario, Canada|Smiths Falls, Ontario, Canada|Thornhill, Ontario, Canada|Drummondville, Quebec, Canada|Calgary, Canada|Mount Pearl, Canada|Truro, Canada|Kuopio, Finland|Oulu, Finland|Turku, Finland|Bondy Cedex, France|Le Creusot, France|Narbonne Cedex, France|Aschaffenburg, Germany|Mainz, Germany|Neuwied, Germany|Schkeuditz, Germany|Athens, Greece|Thessalonikis, Greece|Thessaloniki, Greece|Ahmedabad, India|Belgaum, India|Chennai, India|Coimbatore, India|Jaipur, India|Nagpur, India|Chihuahua, Mexico|Ciudad Juarez, Mexico|Durango, Mexico|Mexico, Mexico|AlmerÃa, Spain|Madrid, Spain|Sevilla, Spain|Bangkok, Thailand|Khon Kaen, Thailand|Antrim, United Kingdom|Belfast, United Kingdom
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