| Outcome Measures: |
Primary: Full Epithelialization of the Wound, Biopsy is performed from the periphery of the ulcer, before and after treatment with vildagliptin, in order to evaluate the above referred outcome. Optic microscopy is used to evaluate the epithelialization of the wound., 3 months of treatment with vildagliptin|Capillary Density, Biopsy is performed from the periphery of the ulcer, before and after treatment with vildagliptin, in order to evaluate the above referred outcome. Capillary density is measured using immunohistochemistry, 3 months of treatment with vildagliptin | Secondary: HIF-1α, The factor is assessed by immunoblot analysis (commercial kits). Arbitrary unit of measure are used to evaluate HIF-1α concentration. Higher values represent more factor., 3 months|VEGF, The factor is assessed by immunoblot analysis (commercial kits).Arbitrary unit of measure are used to evaluate VEGF concentration. Higher values represent more factor., 3 months|VEGF-R1 (Total and Phosphorylated Form), VEGF-R2 (Total and Phosphorylated Form), The factor is assessed by immunoblot analysis (commercial kits). Arbitrary unit of measure are used to evaluate VEGF-R1 concentration. Higher values represent more factor., 3 months|iNOS, The factor is assessed by immunoblot analysis (commercial kits). Arbitrary unit of measure are used to evaluate iNOS concentration. Higher values represent more factor., 3 months
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