| Outcome Measures: |
Primary: Change of Time in Range % at 7 days, at 1 and 6 months, Evaluation of Time in Range % by continuous glycemic monitoring, 7 days, 1 months and 6 months|Change of hypoglycemic events, Change of hypoglycemic events (symptoms and serum glycemia \< 60 mg/dl), 7 days, 1 months and 6 months|Change from Baseline Reactive Hyperemia Index at 3 and 9 months, Change of Endothelial function by the use of Endopat2000 with the evaluation of Reactive Hypereremia Index (normal value of RHI \> 1,27), 7 days, 1 months and 6 months | Secondary: Change from Baseline serum of C- Reactive-Protein (CRP), Variation from baseline serum levels of C- Reactive-Protein (CRP) (mg/dl), 7 days, 1 months and 6 months|Change from Baseline serum levels of Interleukin-6 (IL6), Variation from baseline serum levels of Interleukin-6 (IL6) (pg/ml), 7 days, 1 months and 6 months|Change from Baseline serum levels of ferritin, Variation from baseline serum levels of ferritin (mcg/L), 7 days, 1 months and 6 months|Change of intra and extra-hospital mortality, Change of intra and extra-hospital mortality, 7 days, 1 months and 6 months
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