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Clinical Trial Details

Trial ID: L5832
Source ID: NCT00032487
Associated Drug: Insulin
Title: Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT)
Acronym: VADT
Status: COMPLETED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT00032487/results
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin|DRUG: Glimepiride|DRUG: Rosiglitazone|DRUG: Metformin
Outcome Measures: Primary: Primary Major Macrovascular Events, Myocardial infarction (MI), intervention for coronary artery or Peripheral Vascular Disease (PVD), severe inoperable Coronary Artery Disease (CAD), new or worsening Congestive Heart Failure (CHF), stroke, Cardiovascular (CV) death, or amputation for ischemic gangrene., Post baseline time to the first major macrovascular event up to 82 months | Secondary: Secondary Endpoint, New or worsening angina, new transient ischemic attack (TIA), new intermittent claudication or critical limb ischemia with Doppler evidence or total mortality., Post baseline time to first event up to 82 months
Sponsor/Collaborators: Sponsor: VA Office of Research and Development | Collaborators: National Eye Institute (NEI)|SmithKline Beecham
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 1791
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2000-12-01
Completion Date: 2008-05-30
Results First Posted: 2014-02-12
Last Update Posted: 2017-03-30
Locations: Carl T. Hayden VA Medical Center, Phoenix, Arizona, 85012, United States|Southern Arizona VA Health Care System, Tucson, Tucson, Arizona, 85723, United States|VA Central California Health Care System, Fresno, Fresno, California, 93703, United States|VA Medical Center, Long Beach, Long Beach, California, 90822, United States|VA San Diego Healthcare System, San Diego, San Diego, California, 92161, United States|Miami VA Healthcare System, Miami, FL, Miami, Florida, 33125, United States|Edward Hines, Jr. VA Hospital, Hines, Illinois, 60141-5000, United States|Richard Roudebush VA Medical Center, Indianapolis, Indianapolis, Indiana, 46202-2884, United States|VA Medical Center, Lexington, Lexington, Kentucky, 40502, United States|VA Medical Center, Minneapolis, Minneapolis, Minnesota, 55417, United States|VA Medical Center, Omaha, Omaha, Nebraska, 68105-1873, United States|VA New Jersey Health Care System, East Orange, East Orange, New Jersey, 07018, United States|VA Pittsburgh Health Care System, Pittsburgh, Pennsylvania, 15240, United States|Ralph H Johnson VA Medical Center, Charleston, Charleston, South Carolina, 29401-5799, United States|VA Medical Center, Nashville, Tennessee, 37212-2637, United States|Michael E. DeBakey VA Medical Center (152), Houston, Texas, 77030, United States|VA South Texas Health Care System, San Antonio, San Antonio, Texas, 78229, United States|Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, 23249, United States|VA Medical Center, Salem VA, Salem, Virginia, 24153, United States|VA Puget Sound Health Care System, Seattle, Seattle, Washington, 98108, United States|VA Medical Center, San Juan, San Juan, 00921, Puerto Rico
URL: https://clinicaltrials.gov/show/NCT00032487

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D116 Rosiglitazone small molecule DB00412 Details
D089 Metformin small molecule DB00331 Details