| Outcome Measures: |
Primary: fasting plasma glucose (FPG), In 60 days after starting study treatment, from starting treatment until 60 days|glycosylated hemoglobin (A1C), In 60 days after starting study treatment, from starting treatment until 60 days | Secondary: overall survival (OS), overall survival will be follow up to 2 years. Time to an event (death), or censored status (lost of follow up, withdrawal from the study, or still alive on 2 years) will be recorded. OS will be estimated using Kaplan-Meier method., 2 years|progression free survival (PFS), PFS will be follow up to 2 years. Time to an event (progression or death) or censored status (lost of follow up, withdrawal from the study, or still alive and no progression on 2 years). Assessment of progression will follow RECIST standard Version 1.1. PFS will be estimated using Kaplan-Meier method., 2 years|postprandial glucose (PPG), from starting treatment until 60 days treatment, from starting treatment until 60 days
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