| Outcome Measures: |
Primary: Area under the semaglutide plasma concentration time curve at steady state (semaglutide 0.5 mg), Calculated based on semaglutide measured in blood., 0-168 hours after last administration of semaglutide|Area under the semaglutide plasma concentration time curve at steady state (semaglutide 1.0 mg), Calculated based on semaglutide measured in blood., 0-168 hours after last administration of semaglutide | Secondary: Maximum observed semaglutide plasma concentration at steady state, Calculated based on semaglutide measured in blood., 0-168 hours after last administration of semaglutide|Time to maximum observed semaglutide plasma concentration at steady state, Calculated based on semaglutide measured in blood., 0-168 hours after last administration of semaglutide|Total apparent clearance of semaglutide at steady state, Calculated based on semaglutide measured in blood., 0-168 hours after last administration of semaglutide|Terminal elimination half-life of semaglutide at steady state, Calculated based on semaglutide measured in blood., 0-840 hours after last administration of semaglutide|Apparent volume of distribution of semaglutide at steady state, Calculated based on semaglutide measured in blood., 0-840 hours after last administration of semaglutide|Trough plasma semaglutide concentration, Calculated based on semaglutide measured in blood., Before dosing at day 29, 57, 78, 85 and 92|Dose-corrected accumulation ratio, Calculated based on semaglutide measured in blood., Based on the area under the semaglutide plasma concentration curve from 0-168 hours after the first dose and the area under the semaglutide plasma concentration curve 0-168 hours after the last dose|Area under the semaglutide plasma concentration time curve, Calculated based on semaglutide measured in blood., 0-168 hours after the first dose of semaglutide 0.25 mg (starting dose level)|Maximum observed semaglutide plasma concentration, Calculated based on semaglutide measured in blood., 0-168 hours after the first dose of semaglutide 0.25 mg (starting dose level)|Time to maximum observed semaglutide plasma concentration, Calculated based on semaglutide measured in blood., 0-168 hours after the first dose of semaglutide 0.25 mg (starting dose level)|Number of treatment emergent adverse events (TEAEs), Count and % of adverse events, Visit 2 (Day 1) - visit 23 (Day 120-127)|Number of hypoglycaemic episodes, Count of episodes, Visit 2 (Day 1) - visit 23 (Day 120-127)|Incidence of anti-semaglutide antibodies (positive/negative) at follow-up, Count of episodes, Visit 23 (Day 120-127)
|
