| Outcome Measures: |
Primary: TAK-875 maximum observed plasma concentration (Cmax), Day 14|TAK-875 time at which Cmax occurred (Tmax), Day 14|TAK-875 area under the plasma concentration-time curve from time 0 to time tau, where tau is the length of a dosing interval AUC(0-tau), Day 14|TAK-875 renal clearance (CLr), Day 14|TAK-875 metabolite (M-I) Cmax, Day 14|TAK-875 M-I Tmax, Day 14|TAK-875 M-I AUC(0-tau), Day 14|TAK-875 M-I renal clearance CLr, Day 14 | Secondary: TAK-875 Cmax, Day 1|TAK-875 Tmax, Day 1|TAK-875 AUC(0-tau), Day 1|TAK-875 renal clearance CLr, Day 1|M-I Tmax, Day 1|M-I Cmax, Day 1|M-I AUC(0-tau), Day 1|M-I renal clearance CLr, Day 1|TAK-875 and M-I Cmax ratio, Day 1|TAK-875 and M-I Cmax ratio, Day 14|TAK-875 and M-I AUC(0-tau) ratio, Day 1|TAK-875 and M-I AUC(0-tau) ratio, Day 14|Percent changes from baseline to Day 14 in mean 4-hour concentration values for plasma glucose, Day 14|Percent changes from baseline to Day 14 in mean 4- hour concentration values for insulin, Day 14|Percent changes from baseline to Day 14 in mean 4- hour concentration values for proinsulin, Day 14|Percent changes from baseline to Day 14 in mean 4- hour concentration values for C-peptide, Day 14|Percent changes from baseline to Day 14 in mean 4- hour concentration values for glucagon, Day 14|Percent changes from baseline to Day 14 in mean 4- hour concentration values for total gastric inhibitory polypeptide (GIP), Day 14|Percent changes from baseline to Day 14 in mean 4- hour concentration values for total glucagon-like peptide-1 (GLP-1), Day 14|Percent changes from baseline to Day 14 in mean 24-hour concentration values for plasma glucose, Day 14|Percent changes from baseline to Day 14 in mean 24- hour concentration values for insulin, Day 14|Percent changes from baseline to Day 14 in mean 24- hour concentration values for proinsulin, Day 14|Percent changes from baseline to Day 14 in mean 24- hour concentration values for C-peptide, Day 14|Percent changes from baseline to Day 14 in mean 24- hour concentration values for glucagon, Day 14|Percent changes from baseline to Day 14 in mean 24- hour concentration values for total gastric inhibitory polypeptide (GIP), Day 14|Percent changes from baseline to Day 14 in mean 24- hour concentration values for total glucagon-like peptide-1 (GLP-1), Day 14|Absolute changes from baseline to Day 14 in mean 4-hour concentration values for plasma glucose, Day 14|Absolute changes from baseline to Day 14 in mean 4- hour concentration values for insulin, Day 14|Absolute changes from baseline to Day 14 in mean 4- hour concentration values for proinsulin, Day 14|Absolute changes from baseline to Day 14 in mean 4- hour concentration values for C-peptide, Day 14|Absolute changes from baseline to Day 14 in mean 4- hour concentration values for glucagon, Day 14|Absolute changes from baseline to Day 14 in mean 4- hour concentration values for total gastric inhibitory polypeptide (GIP), Day 14|Absolute changes from baseline to Day 14 in mean 4- hour concentration values for total glucagon-like peptide-1 (GLP-1), Day 14|Absolute changes from baseline to Day 14 in mean 24-hour concentration values for plasma glucose, Day 14|Absolute changes from baseline to Day 14 in mean 24- hour concentration values for insulin, Day 14|Absolute changes from baseline to Day 14 in mean 24- hour concentration values for proinsulin, Day 14|Absolute changes from baseline to Day 14 in mean 24- hour concentration values for C-peptide, Day 14|Absolute changes from baseline to Day 14 in mean 24- hour concentration values for glucagon, Day 14|Absolute changes from baseline to Day 14 in mean 24- hour concentration values for total gastric inhibitory polypeptide (GIP), Day 14|Absolute changes from baseline to Day 14 in mean 24- hour concentration values for total glucagon-like peptide-1 (GLP-1), Day 14|Percent change from baseline to 24-hours post Day 13 dose in homeostasis model assessment of ß-cell function, Day 13|Percent change from baseline to 24-hours post Day 14 dose in homeostasis model assessment of ß-cell function, Day 14|Absolute change from baseline to 24-hours post Day 13 dose in homeostasis model assessment of ß-cell function, Day 13|Absolute change from baseline to 24-hours post Day 14 dose in homeostasis model assessment of ß-cell function, Day 14|Percent change from baseline to Day 14 in insulinogenic index, Day 14|Absolute change from baseline to Day 14 in insulinogenic index, Day 14
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