| Outcome Measures: |
Primary: Number of Participants With One or More Serious Adverse Event(s) (SAEs), Number of participants with one or more SAEs considered by the investigator to be related to study drug administration. A summary of SAEs and other non-serious adverse events (AEs), regardless of causality, were reported in the Reported Adverse Events module, Baseline through Day 43 (Part A) and Day 57 (Part B and C) | Secondary: Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of Tirzepatide in Part A., Area under the concentration versus time curve from zero to infinity (AUC \[0-∞\]) of Tirzepatide in Part A., Predose, 8hours(h), 24h,48h,72h,96h,120h,168h,336h postdose, day 29, day 43|Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of Tirzepatide in Part B, Area under the concentration versus time curve during 1 dosing interval (AUC \[0-τ\]) of Tirzepatide in Part B. τ equals 168 hours., Predose, 8hours(h), 24h,48h,72h,168h postdose|Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of Tirzepatide in Part C, Area under the concentration versus time curve during 1 dosing interval (AUC \[0-τ\]) of Tirzepatide in Part C. τ equals 168 hours., Predose, 8hours(h), 24h,48h,72h,168h postdose|Pharmacodynamics (PD): Ratio of AUC of Glucose on Day 2 to Baseline (Part C), PD: Glucose area under the concentration versus time curve from time 0 to 2 hours (AUC\[0-2h\]) in Part C. Ratio to Baseline (Day -1) AUC (0-2h)., Pre-glucose dose, 0.5, 1, 1.5, 2 hours post-glucose dose on Day -1 and Day 2|Pharmacodynamics (PD): Ratio of AUC of Glucose on Day 23 to Baseline (Part C), PD: Glucose area under the concentration versus time curve from time 0 to 2 hours (AUC\[0-2h\]) in Part C. Ratio to Baseline (Day -1) AUC (0-2h)., Pre-glucose dose, 0.5, 1, 1.5, 2 hours post-glucose dose on Day -1 and Day 23
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| Locations: |
Miami Research Associates, South Miami, Florida, 33143, United States|For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician., Singapore, 117597, Singapore
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