| Outcome Measures: |
Primary: Change from baseline in HbA1c at week 24, Baseline, week 24 | Secondary: Change from baseline in HbA1c, FPG, insulin and GLP-1 at week 4, 8, 12, 18, 24, Baseline, week 4, 8, 12, 18, 24|Change from baseline in 2hr PPG and postprandial insulin at week 24, Baseline, week 24|Change from baseline in FPG and HbA1c according to HbA1c at baseline(7~8%,8~9%, 9~10%, 10~11%), Baseline, week 4, 8, 12, 18, 24|Percentage of patients achieving HbA1c <7% at week 24, week 24|Percentage of patients achieving HbA1c <6.5% at week 24, week 24|Percentage of patients reaching FPG <126mg/dL at week 24, week 24|Percentage of patients reaching 2hr PPG <200mg/dL at week 24, week 24|Percentage of patients adjusting to the high dose, week 24|Percentage of withdrawing patients due to uncontrolled glucose, week 24|Change from baseline in serum lipid(T. cholesterol, HDL, LDL, TG) at week 24, week 24|Glycemic variability, Glycemic variability is measured by M-value. M-value = ∑{\|10\*log(blood glucose/100)\|3}/n+{Max(blood glucose)-Min(blood glucose)}/20, M\<19: good, 19≤M\<32: fair, 32≤M: poor, Baseline, week 8, 18, 24
|
| Locations: |
Bucheon St. Mary's Hospital, Bucheon, Korea, Republic of|Seoul National University Bundang Hospital, Bundang, Korea, Republic of|Chonbuk National University Hospital, Chonju, Korea, Republic of|Kyungpook University Hospital, Daegu, Korea, Republic of|Yeungnam University Medical Center, Daegu, Korea, Republic of|National Health Insurance Coporation Ilsan Hospital, Ilsan, Korea, Republic of|Inha University Hospital, Incheon, Korea, Republic of|Inje University Pusan Baik Hospital, Pusan, Korea, Republic of|Pusan National University Hospital, Pusan, Korea, Republic of|Asan Medical Center, Seoul, Korea, Republic of|Eulji Medical Center, Seoul, Korea, Republic of|Hallym University Medical Center(Gangdong), Seoul, Korea, Republic of|Hallym University Medical Center(Gangnam), Seoul, Korea, Republic of|Kangbuk Samsung Hospital, Seoul, Korea, Republic of|Korea University Guro Hospital, Seoul, Korea, Republic of|Kyung Hee University Hospital, Seoul, Korea, Republic of|Samsung Medical Center, Seoul, Korea, Republic of|Seoul St. Mary's hospital, Seoul, Korea, Republic of|Severance Hospital, Seoul, Korea, Republic of|Ajou University Hospital, Suwon, Korea, Republic of|Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of
|
