| Trial ID: | L6260 |
| Source ID: | NCT00631488
|
| Associated Drug: |
Mk-0893
|
| Title: |
A Study to Test the Effectiveness and Safety of MK0893 in Combination With Other Drugs Used to Treat Type 2 Diabetes (0893-015)
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
YES
|
| Results: |
https://ClinicalTrials.gov/show/NCT00631488/results
|
| Conditions: |
Diabetes Mellitus, Type 2
|
| Interventions: |
DRUG: MK-0893|DRUG: Sitagliptin|DRUG: Metformin|DRUG: Placebo for MK-0893|DRUG: Placebo for Sitagliptin|DRUG: Placebo for Metformin
|
| Outcome Measures: |
Primary: Change From Baseline (BL) to Week 4 in 24-hour Weighted Mean Glucose (WMG) Levels, BL, 4 weeks (end of double-blind treatment period) | Secondary: Change From BL to Week 4 in Fasting Plasma Glucose (FPG), BL, 4 weeks (end of double-blind treatment period)|Change From BL to Week 4 in 2-hr Glucose Area Under The Curve (AUC), BL, 4 weeks (end of double-blind treatment period)|Change From BL to Week 4 in the 2-Hour Total GLP-1 Total AUC, Glucagon-Like Peptide-1 (GLP-1) is an incretin hormone that acts as a potent insulin secretegogue in response to nutrient ingestion and stimulates glucose disposition. The total AUC of Total GLP-1 levels was calculated from blood sample data measured after the morning meal., BL, 4 weeks (end of double-blind treatment period)|Change From BL to Week 4 in the 2-Hour Active GLP-1 Total AUC, GLP-1 is cleaved from proglucagon to form the active peptide GLP-1. The active form promotes suppression of glucagon secretion. The total AUC of Active GLP-1 levels was calculated from blood sample data measured after the morning meal., BL, 4 weeks (end of double-blind treatment period)
|
| Sponsor/Collaborators: |
Sponsor: Merck Sharp & Dohme LLC
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE2
|
| Enrollment: |
146
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
|
| Start Date: |
2008-02
|
| Completion Date: |
2009-01
|
| Results First Posted: |
2012-02-17
|
| Last Update Posted: |
2017-01-02
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| Locations: |
|
| URL: |
https://clinicaltrials.gov/show/NCT00631488
|
