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Clinical Trial Details

Trial ID: L6568
Source ID: NCT02721888
Associated Drug: Liraglutide
Title: Effect of Liraglutide on Fatty Liver Content and Lipoprotein Metabolism
Acronym: LIRA-NAFLD/LIP
Status: TERMINATED
Study Results: NO
Results:
Conditions: Type 2 Diabetes
Interventions: DRUG: Liraglutide|DRUG: MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)|BIOLOGICAL: Blood sample|OTHER: Kinetic substudy (10 patients)
Outcome Measures: Primary: Effect of liraglutide on fatty liver content evaluated by proton-spectroscopy (1H-spectroscopy and lipoprotein kinetics, in patients with type 2 diabetes, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on Very Low Density Lipoprotein 1 (VLDL1) apolipoprotein B (apoB) production rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on Very Low Density Lipoprotein 2 (VLDL2) apolipoprotein B (apoB) production rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on Intermediate Density Lipoprotein (IDL) apolipoprotein B (apoB) production rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on Low Density Lipoprotein (LDL) apolipoprotein B (apoB) production rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on High Density Lipoprotein (HDL) apolipoprotein A1 (apoA1) production rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on Very Low Density Lipoprotein 1 (VLDL1) apolipoprotein B (apoB) fractional catabolic rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on Very Low Density Lipoprotein 2 (VLDL2) apolipoprotein B (apoB) fractional catabolic rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on Intermediate Density Lipoprotein (IDL) apolipoprotein B (apoB) fractional catabolic rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on Low Density Lipoprotein (LDL) apolipoprotein B (apoB) fractional catabolic rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Effects of liraglutide on High Density Lipoprotein (HDL) apolipoprotein A1 (apoA1) fractional catabolic rate, Before and after 6 month-treatment with liraglutide (1.2 mg/day) | Secondary: Modification of body weight, Modification of weight, induced by liraglutide 1.2 mg/d therapy., Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Modification of subcutaneous fat by Magnetic Resonance Imaging (MRI), Modification of subcutaneous fat by MRI induced by liraglutide 1.2mg/d therapy, Before and after 6 month-treatment with liraglutide (1.2 mg/day)|Modification of visceral fat by Magnetic Resonance Imaging (MRI), Modification of visceral fat by MRI induced by liraglutide 1.2mg/d therapy, Before and after 6 month-treatment with liraglutide (1.2 mg/day)
Sponsor/Collaborators: Sponsor: Centre Hospitalier Universitaire Dijon
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 127
Study Type: INTERVENTIONAL
Study Designs: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2012-07-10
Completion Date:
Results First Posted:
Last Update Posted: 2024-02-22
Locations: CHU de Dijon, Dijon, 21079, France
URL: https://clinicaltrials.gov/show/NCT02721888