| Outcome Measures: |
Primary: Monocyte count, The amount of monocytes following 60 minutes of adrenaline infusion compared to baseline to asses the adrenaline effect on the inflammatory response., Change from baseline compared to after 1 hour | Secondary: Leukocyte count, Measurement of the amount of leukocytes, Change from baseline at day 30, 60 and 180 minutes 1, day 3 and day 7 after adrenaline infusion|Leukocyte phenotype, Measuring several phenotypes by using a pre-defined panel of interest with flow-cytometry ( e.g. NK-cells, granulocytes), Change from baseline at day 30, 60 and 180 minutes 1, day 3 and day 7 after adrenaline infusion|Pro-inflammatory proteins, Pro-inflammatory proteins using Olink Proteomics AB inflammation panel with 92 circulating inflammatory proteins ( e.g. EN-rage, FIT3L), Change from baseline at day 30, 60 and 180 minutes 1, day 3 and day 7 after adrenaline infusion|Inflammation plasma parameters, Inflammatory plasma protein using ELISA, ( e.g high sensitive-crp), Change from baseline at 30, 60 and 180 minutes day 1, day 3 and day 7 after adrenaline infusion|Atherogenic parameters, Atherogenic parameters using ELISA method including but not limited to, VCAM-1, ICAM-1, E-Selectin, P-selectin, PAI-1, Plasma Endothelin, Change from baseline at 30, 60 and 180 minutes day 1, day 3 and day 7 after adrenaline infusion|Insulin, Plasma levels of insulin, Change from baseline at, 60 and 180 minutes|Adrenaline, Plasma levels of adrenaline, Change from baseline at 30, 60 and 180 minutes|Noradrenaline, Plasma levels of noradrenaline, Change from baseline at 30, 60 and 180 minutes|Glucose variability, Glucose variability measured by the blinded continuous glucose monitor including but not limited to, measuring time within range, amount of hypoglycaemic events, amount of hyperglycaemic events., 2 weeks|Ex vivo cytokines, Ex vivo production of pro- and anti-inflammatory cytokines and chemokines after ex vivo stimulation of isolated monocytes, including TNF-α, IL-6, IL-10 and IL-1β., Change from baseline at 30, 60 and 180 minutes, day 1, day 3 and day 7 after adrenaline infusion|Distribution of monocyte subset, Distribution of pro- and anti-inflammatory monocyte subsets using FACS (Fluorescence-activated Cell Sorting), Change from baseline at 30, 60 and 180 minutes, day 1, day 3 and day 7 after adrenaline infusion
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