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Clinical Trial Details

Trial ID: L6994
Source ID: NCT01507597
Associated Drug: Native Human Glucagon-Like Peptide-1 ( Glp-1(7-36))
Title: The Effect of GLP-1 on the Inhibition of Glucagon Secretion
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: Type 2 Diabetes|Type 1 Diabetes
Interventions: DRUG: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))|DRUG: NaCl|DRUG: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))|DRUG: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Outcome Measures: Primary: Plasma Glucagon response to the GLP-1 infusion / glucose clamp, The collection of blood samples will be done during the 210 min GLP-1 infusion / glucose clamp-session, At 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210 min|Plasma GLP-1 response to the GLP-1 infusion / glucose clamp, The collection of blood samples will be done during the 210 min GLP-1 infusion / glucose clamp-session, At 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210 min|Plasma Glucose response to the GLP-1 infusion / glucose clamp, The collection of blood samples will be done during the 210 min GLP-1 infusion / glucose clamp-session, At 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210 min | Secondary: Resting Metabolic Rate response to the GLP-1 infusion / glucose clamp, Assessed by indirect calorimetry during the GLP-1 infusion / glucose clamp-session, at 0, 120, and 180 min|Hunger scores response to the GLP-1 infusion / glucose clamp, Assessed by VAS during the 210 min GLP-1 infusion / glucose clamp-session, At 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210 min|plasma Insulin response to the GLP-1 infusion / glucose clamp, The collection of blood samples will be done during the 210 min GLP-1 infusion / glucose clamp-session, At 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210 min|plasma GIP response to the GLP-1 infusion / glucose clamp, The collection of blood samples will be done during the 210 min GLP-1 infusion / glucose clamp-session, At 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210 min|Food Intake, Assessed by ad'libitum meal after the 210 min GLP-1 infusion / glucose clamp., at 210 min
Sponsor/Collaborators: Sponsor: University Hospital, Gentofte, Copenhagen
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases:
Enrollment: 30
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Start Date: 2011-12
Completion Date: 2013-08
Results First Posted:
Last Update Posted: 2013-12-10
Locations: Gentofte University Hospital, Hellerup, DK-2900, Denmark
URL: https://clinicaltrials.gov/show/NCT01507597

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress