| Outcome Measures: |
Primary: heart rate variability（HRV）, All participants were given ambulatory electrocardiogram.The time domain analysis and frequency domain analysis of heart rate variability are included in the holter ECG report., baseline and 12 weeks later | Secondary: E/I difference, Take an average of 6 deep breaths per minute, record the difference between the maximum heart rate and the minimum heart rate during deep breathing, basline and 12 weeks later|30/15 ratio, The heart rate in lying position was measured, and the R-R interval in more than 30 beats was measured after standing, and the ratio between the longest R-R interval in the 25-35 beats and the shortest R-R interval in the 10-15 beats after standing was calculated, basline and 12 weeks later|Valsalva action, After deep inhalation, hold your breath as much as possible, and then blow air into the modified sphygmomanometer to keep the pressure of the sphygmomanometer at 40mmHg, continue for 10-15s, and then relax for 1 minute, a total of 3 minutes. At the same time, ECG was recorded to record the ratio of maximum heart rate to minimum heart rate, basline and 12 weeks later|the difference between lying and Orthostatic blood pressure, Blood pressure was measured in the supine position. The patient was asked to stand immediately, and blood pressure was measured at the first and fifth minutes, basline and 12 weeks later|grip strength tests, First, the basic blood pressure and the maximum grip strength were measured, and the blood pressure was measured after 5 minutes of continuous hard clenching with the grip apparatus (the force used was 30% of the maximum grip strength measured), and the blood pressure difference was calculated, basline and 12 weeks later|BMI, It is calculated by dividing a person's weight in kg by their height in meters squared, basline and 12 weeks later|FBG, Fasting glucose, basline and 12 weeks later|Fins, Fasting insulin, basline and 12 weeks later|Fc-peptide, Fasting c-peptide, basline and 12 weeks later|HOMA-IR, calculated by HOMA Calculator v2.2.3, basline and 12 weeks later|HbA1c, Reflect the average blood sugar of 3 months, basline and 12 weeks later|Total cholesterol, one of serum biochemical index, basline and 12 weeks later|triglyceride, one of serum biochemical index, basline and 12 weeks later|HDL, high-density lipoprotein，one of serum biochemical index, basline and 12 weeks later|LDL, low density lipoprotein，one of serum biochemical index, basline and 12 weeks later|UA, Uric Acid，one of serum biochemical index, basline and 12 weeks later|creatinine, one of serum biochemical index, basline and 12 weeks later|eGFR, Estimated glomerular filtration rate，one of serum biochemical index, basline and 12 weeks later|Urinary trace albumin/urinary creatinine, urine protein test urine protein urine protein test, basline and 12 weeks later
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