| Outcome Measures: |
Primary: Nailfold microcirculation morphological integral, Nail fold capillary microscopy examination, Up to three and a half months|Nailfold microcirculation blood flow integral, Nail fold capillary microscopy examination, Up to three and a half months|Nail fold microcirculation perivascular loop integral, Nail fold capillary microscopy examination, Up to three and a half months | Secondary: The content of blood serum creatinine, Intravenous blood sampling, Up to three and a half months|The content of blood urea nitrogen, Intravenous blood sampling，uronoscopy, Up to three and a half months|The content of blood cystatin C, Intravenous blood sampling, Up to three and a half months|eGFR, Intravenous blood sampling, Up to three and a half months|The content of blood albumin, Intravenous blood sampling, Up to three and a half months|The quantification of urinary protein, Uronoscopy, Up to three and a half months|The content of hemoglobin, Intravenous blood sampling, Up to three and a half months
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