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Clinical Trial Details

Trial ID: L0010
Source ID: NCT04381143
Associated Drug: Aspirin 100 Mg Oral Tablet
Title: ASPIrin in Reducing Events in Dialysis ( ASPIRED )
Acronym:
Status: RECRUITING
Study Results: NO
Results:
Conditions: CKD (Chronic Kidney Disease) Stage 5D
Interventions: DRUG: Aspirin 100 mg Oral Tablet|DRUG: Matching Placebo
Outcome Measures: Primary: Number of Participants with composite of major cardiovascular events (3-point MACE), A composite of cardiovascular death, myocardial infarction, or ischemic stroke., From trial initiation to any event first occurrence, up to 5 years. | Secondary: Number of Participants with composite of the primary outcome plus all-cause death, A composite of cardiovascular death, myocardial infarction, ischemic stroke or death., From trial initiation to any event first occurrence, up to 5 years.|Number of Participants with composite of major cardiovascular events, hospitalised unstable angina (UA) and hospitalised transient ischaemic attack (TIA), A composite of cardiovascular death, myocardial infarction, ischemic stroke, hospitalised unstable angina (UA) or hospitalised transient ischaemic attack (TIA), From trial initiation to any event first occurrence, up to 5 years.|Number of Participants with cardiovascular death, Death due to CV cause., From trial initiation to any event first occurrence, up to 5 years.|Myocardial infarction, From trial initiation to any event first occurrence, up to 5 years.|Number of Participants with stroke, From trial initiation to any event first occurrence, up to 5 years.|Number of Participants with all-cause death, Death for any reason., From trial initiation to any event first occurrence, up to 5 years.|Number of Participants with coronary revascularization, From trial initiation to any event occurrence, up to 5 years.|Number of Participants with fistula or graft thrombosis, From trial initiation to any event occurrence, up to 5 years.|Number of Participants with haemorrhagic stroke, From trial initiation to any event occurrence, up to 5 years.|Number of Participants with ischemic events, Defined as a composite of myocardial infarction (MI), coronary death, ischemic stroke, or any revascularization procedure (i.e, exclusion of noncoronary cardiac deaths and strokes confirmed to be haemorrhagic)., From trial initiation to any event occurrence, up to 5 years. | Other: Major bleeding, Major bleeding is defined based on modified International Society on Thrombosis and Haemostasis (ISTH) definition, including fatal bleeding, and/or symptomatic bleeding in a critical area or organ, such as intracranial, intra-spinal, intra-ocular, retro-peritoneal, intra-articular or pericardial, or intramuscular with compartment syndrome, or bleeding into a surgical site requiring re-operation, and/or bleeding leading to hospitalization., From trial initiation to any event first occurrence, up to 5 years.
Sponsor/Collaborators: Sponsor: Guangdong Provincial People's Hospital | Collaborators: The George Institute
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 9000
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2020-07-30
Completion Date: 2026-12
Results First Posted:
Last Update Posted: 2025-03-12
Locations: The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China|The First Hospital of Lanzhou University, Lanzhou, Gansu, China|Chaozhou Center Hospital, Chaozhou, Guangdong, China|Dongguan Donghua Hospital, Dongguan, Guangdong, 523413, China|Dongguan Eighth People's Hospital, Dongguan, Guangdong, China|Dongguan Marina Bay Center Hospital, Dongguan, Guangdong, China|Dongguan People's Hospital, Dongguan, Guangdong, China|Dongguan Songshan Lake Center Hospital, Dongguan, Guangdong, China|The Second People Hospital of Foshan Nanhai, Foshan, Guangdong, 528251, China|Foshan Nanhai District People's Hospital, Foshan, Guangdong, China|Foshan No.1 people's hospital, Foshan, Guangdong, China|Foshan Sanshui District People's Hospital, Foshan, Guangdong, China|Foshan Sanshui People's Hospital, Foshan, Guangdong, China|Foshan Second People's Hospital, Foshan, Guangdong, China|Guangdong Provincial Hospital of Integrative Medicine, Foshan, Guangdong, China|Shunde People's Hospital, Foshan, Guangdong, China|The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, 225200, China|The first Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China|Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong, 510235, China|Guangzhou Redcross Hospital, Guangzhou, Guangdong, 510240, China|The first Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China|Guangdong Agricultural Reclamation Central Hospital, Guangzhou, Guangdong, China|Guangdong Cliffod Hospital, Guangzhou, Guangdong, China|Guangdong Provincial Peoples Hospital, Guangzhou, Guangdong, China|Guangzhou First People's Hospital, Guangzhou, Guangdong, China|Hua Du District People's Hospital of Guangzhou, Guangzhou, Guangdong, China|Panyu District people's hospital of Guangzhou, Guangzhou, Guangdong, China|The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China|The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China|The Sixth Affiliated Hospital of Sun yat-sen University, Guangzhou, Guangdong, China|The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China|The First Affiliated Hospital of Sun Yat-sen University, Guanzhou, Guangdong, China|Heyuan People's Hospital, Heyuan, Guangdong, China|Huizhou First People Hospital, Huizhou, Guangdong, 516001, China|Huizhou Central People's Hospital, Huizhou, Guangdong, China|Jiangmen Center hospital, Jiangmen, Guangdong, China|Jieyang People's Hospital, Jieyang, Guangdong, China|Kaiping Center Hospital, Kaiping, Guangdong, China|Lianjiang People's Hospital, Lianjiang, Guangdong, China|Lufeng People's Hospital, Lufeng, Guangdong, China|Maoming Hospital of Traditional Chinese Medicine, Maoming, Guangdong, China|Maoming People's Hospital, Maoming, Guangdong, China|Meizhou People's Hospital, Meizhou, Guangdong, 514011, China|The Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital, Meizhou, Guangdong, 514799, China|Nanxiong People Hospital, Nanxiong, Guangdong, 512499, China|Puning People's Hospital, Puning, Guangdong, China|Qingyuan People's Hospital, Qingyuan, Guangdong, 511518, China|Fogang People Hospital, Qingyuan, Guangdong, 511600, China|Qingyuan Hospital of Traditional Chinese Medicine, Qingyuan, Guangdong, China|The first Affiliated Hospital of Shantou Medical University, Shantou, Guangdong, 515041, China|Shantou Chaonan Minsheng Hospital, Shantou, Guangdong, 515144, China|Shanwei People's Hospital, Shanwei, Guangdong, China|Shenshan Medical Center, Memorial Hospital of Sun Yat-sen University, Shanwei, Guangdong, China|Wengyuan People Hospital, Shaoguan, Guangdong, 512600, China|Shaoguan First People's Hospital, Shaoguan, Guangdong, China|The First People's Hospital of Shaoguan, Shaoguan, Guangdong, China|Yuebei People's Hospital, Shaoguan, Guangdong, China|The Seventh Affiliated Hospital of Sun Yat-sen, Shenzhen, Guangdong, 510275, China|Shenzhen Baoan People's Hospital, Shenzhen, Guangdong, China|Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China|Shenzhen Longhua District People's Hospital, Shenzhen, Guangdong, China|Shenzhen No.2 people's hospital, Shenzhen, Guangdong, China|The Eighth Affiliated Hospital of Sun Yat-sen University (Futian, Shenzhen), Shenzhen, Guangdong, China|ShunDe Hospital Guangzhou University of Chinese Medicine, Shunde, Guangdong, China|Shunde Hospital of Southern Medical University, Shunde, Guangdong, China|Yangjiang Hospital of Traditional Chinese Medicine, Yangjiang, Guangdong, China|Yangjiang People's Hospital, Yangjiang, Guangdong, China|Yunfu People's Hospital, Yunfu, Guangdong, China|The Fourth Affiliated Hospital of Guangzhou Medical University, Zengcheng, Guangdong, China|The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524000, China|Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China|Zhaoqing first people's hospital, Zhaoqing, Guangdong, China|Zhongshan City People's Hospital, Zhongshan, Guangdong, China|Zhongshan Traditional Chinese Hospital, Zhongshan, Guangdong, China|Zhongshan Xiaolan People's Hospital, Zhongshan, Guangdong, China|Jinwan Center Hospital of Zhuhai, Zhuhai, Guangdong, China|The fifth affiliated hospital of sun yat-sen university, Zhuhai, Guangdong, China|Zhuhai People's Hospital, Zhuhai, Guangdong, China|The Affiliated Hospital of Youjiang Ethnic Medicine College, Baise, Guangxi, China|The first affiliated hospital of Guangxi Medical University, Nanning, Guangxi, China|People Hospital of Yingde City Guangdong Province, Yingde, Guang, China|Anshun People Hospital, Anshun, Guizhou, 561099, China|Guizhou Province Peple's Hospital, Guiyang, Guizhou, China|Hainan Provincial People's Hospital, Haikou, Hainan, China|Xinyang Central Hospital, Xinyang, Henan, China|The Central Hospital of Wuhan, Wuhan, Hubei, China|The Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China|Tongji Hospital, Tongji Medical College of Huazhong Science and Technology University, Wuhan, Hubei, China|Wuhan No.1 People's Hospital, Wuhan, Hubei, China|Yichang central people's hospital, Wuhan, Hubei, China|Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China|Hunan Provincial People's Hospital, Changsha, Hunan, China|The third Xiangya Hospital of Central South University, Changsha, Hunan, China|Xiangya Hospital Central South University, Changsha, Hunan, China|The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China|Ganzhou Municiple Hospital, Ganzhou, Jiangxi, 341000, China|Ganzhou People's Hospital, Ganzhou, Jiangxi, China|Jiujiang No.1people's Hospital, Jiujiang, Jiangxi, China|Jiangxi Province Peple's Hospital, Nanchang, Jiangxi, China|The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China|General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China|The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China|The First Affiliated Hospital of Air Force Military Medical University, Xi'an, Shanxi, China|Sichuan Province People's Hospital, Chengdu, Sichuan, China|The First People's Hospital of Kashi Prefecture, Kashi, Xinjiang, China|The First Affiliated Hospital of Shihezi University Medical College, Shihezi, Xinjiang, China|The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang, China|The People's hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, China|Fengqing People's Hospital of Yunnan Province, Lincang, Yunnan, China|The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China
URL: https://clinicaltrials.gov/show/NCT04381143

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