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Clinical Trial Details

Trial ID: L1040
Source ID: NCT05915286
Associated Drug: Furosemide
Title: Diuretic Use in Hemodialysis Patients With Residual Renal Function
Acronym: DIURESED
Status: SUSPENDED
Study Results: NO
Results:
Conditions: End Stage Renal Disease on Dialysis
Interventions: DRUG: Furosemide|DRUG: Chlorthalidone
Outcome Measures: Primary: Change in 24-hour urine output, Change in urine output measured from 24-hour urine collection., Week 1|Change in 24-hour urine output, Change in urine output measured from 24-hour urine collection., Week 2|Change in 24-hour urine output, Change in urine output measured from 24-hour urine collection., Week 3|Change in 24-hour urine output, Change in urine output measured from 24-hour urine collection., Week 4|Change in 24-hour urine output, Change in urine output measured from 24-hour urine collection., Week 5|Change in residual renal function, Calculated based on weekly bloodwork (urea and creatinine levels) and 24-hour urine collection., Week 1|Change in residual renal function, Calculated based on weekly bloodwork (urea and creatinine levels) and 24-hour urine collection., Week 2|Change in residual renal function, Calculated based on weekly bloodwork (urea and creatinine levels) and 24-hour urine collection., Week 3|Change in residual renal function, Calculated based on weekly bloodwork (urea and creatinine levels) and 24-hour urine collection., Week 4|Change in residual renal function, Calculated based on weekly bloodwork (urea and creatinine levels) and 24-hour urine collection., Week 5 | Secondary: Interdialytic weight gain, Patient weight measured in kilograms, Week 1|Interdialytic weight gain, Patient weight measured in kilograms, Week 2|Interdialytic weight gain, Patient weight measured in kilograms, Week 3|Interdialytic weight gain, Patient weight measured in kilograms, Week 4|Interdialytic weight gain, Patient weight measured in kilograms, Week 5|Patient-reported outcomes - ESAS-r, Patient reported outcomes using the Edmonton Symptom Assessment System-revised (ESAS-r) questionnaire., Week 1|Patient-reported outcomes - ESAS-r, Patient reported outcomes using the Edmonton Symptom Assessment System-revised (ESAS-r) questionnaire., Week 2|Patient-reported outcomes - ESAS-r, Patient reported outcomes using the Edmonton Symptom Assessment System-revised (ESAS-r) questionnaire., Week 3|Patient-reported outcomes - ESAS-r, Patient reported outcomes using the Edmonton Symptom Assessment System-revised (ESAS-r) questionnaire., Week 4|Patient-reported outcomes - ESAS-r, Patient reported outcomes using the Edmonton Symptom Assessment System-revised (ESAS-r) questionnaire., Week 5|Patient-reported outcomes - Muscle cramps, Patient reported outcomes using a muscle cramps question., Week 1|Patient-reported outcomes - Muscle cramps, Patient reported outcomes using a muscle cramps question., Week 2|Patient-reported outcomes - Muscle cramps, Patient reported outcomes using a muscle cramps question., Week 3|Patient-reported outcomes - Muscle cramps, Patient reported outcomes using a muscle cramps question., Week 4|Patient-reported outcomes - Muscle cramps, Patient reported outcomes using a muscle cramps question., Week 5|Adverse effects, Adverse effects based on symptoms and weekly bloodwork., Week 1|Adverse effects, Adverse effects based on symptoms and weekly bloodwork., Week 2|Adverse effects, Adverse effects based on symptoms and weekly bloodwork., Week 3|Adverse effects, Adverse effects based on symptoms and weekly bloodwork., Week 4|Adverse effects, Adverse effects based on symptoms and weekly bloodwork., Week 5|Urine furosemide levels, Urine furosemide levels from weekly urine samples, Week 3|Urine furosemide levels, Urine furosemide levels from weekly urine samples, Week 4|Urine furosemide levels, Urine furosemide levels from weekly urine samples, Week 5
Sponsor/Collaborators: Sponsor: University of Alberta
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 34
Study Type: INTERVENTIONAL
Study Designs: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2023-05-29
Completion Date: 2026-02-01
Results First Posted:
Last Update Posted: 2025-03-25
Locations: University of Alberta, Edmonton, Alberta, T6G 2B7, Canada
URL: https://clinicaltrials.gov/show/NCT05915286