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Clinical Trial Details

Trial ID: L1050
Source ID: NCT03315143
Associated Drug: Sotagliflozin
Title: Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk
Acronym: SCORED
Status: TERMINATED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT03315143/results
Conditions: Heart Failure|Type 2 Diabetes Mellitus|Chronic Kidney Diseases
Interventions: DRUG: Sotagliflozin|DRUG: Placebo
Outcome Measures: Primary: Number of Total Occurrences of Cardiovascular (CV) Death, Hospitalizations for Heart Failure (HHF) and Urgent Visits for Heart Failure (HF), Combined endpoint of the total number of occurrences (first and potentially subsequent) of CV death, HHF, and urgent HF visits after randomization. Events that occurred during the study were calculated as the total number of events per 100 person-years of follow-up., Up to 30 months | Secondary: Total Number of Occurrences of HHF and Urgent HF Visits, Combined endpoint of the total occurrences (first and potentially subsequent) of HHF and urgent HF visits after randomization. Events that occurred during the study were calculated as the total number of events per 100 person-years of follow-up., Up to 30 months|Number of Deaths From Cardiovascular Causes, Number of events that occurred during the study were calculated as the total number of events per 100 person-years of follow-up., Up to 30 months|Total Number of Occurrences of CV Death, HHF, Non-fatal Myocardial Infarction and Non-fatal Stroke, Combined endpoint of the total number of occurrences (first and potentially subsequent) of CV death, HHF, non-fatal stroke, and non-fatal myocardial infarction after randomization. Events that occurred during the study were calculated as the total number of events per 100 person-years of follow-up., Up to 30 months|Total Number of Occurrences of HHF, Urgent HF Visit, CV Death, and HF While Hospitalized, Combined endpoint of the total number of occurrences (first and potentially subsequent) after randomization of HHF, urgent HF visits, CV Death, and HF while hospitalized. Events that occurred during the study were calculated as the total number of events per 100 person-years of follow-up., Up to 30 months|Number of Occurrences After Randomization of the Composite of Sustained ≥50% Decrease in Estimated Glomerular Filtration Rate (eGFR) From Baseline (for ≥30 Days), Chronic Dialysis, Renal Transplant, or Sustained eGFR <15 mL/Min/1.73 m^2 (for ≥30 Days), Events that occurred during the study were calculated as the total number of events per 100 person-years of follow-up., Up to 30 months|Number of Deaths From Any Cause, Number of events that occurred during the study were calculated as the total number of events per 100 person-years of follow-up., Up to 30 months|Total Number of Occurrences of CV Death, Non-fatal Myocardial Infarction and Non-fatal Stroke, Combined endpoint of the total number of occurrences (first and potentially subsequent) of CV death and urgent HF visits after randomization. Events that occurred during the study were calculated as the total number of events per 100 person-years of follow-up., Up to 30 months
Sponsor/Collaborators: Sponsor: Lexicon Pharmaceuticals | Collaborators: Sanofi
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 10584
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Start Date: 2017-12-19
Completion Date: 2020-07-08
Results First Posted: 2022-10-28
Last Update Posted: 2022-10-28
Locations: Investigational Site Number 8400017, Birmingham, Alabama, 35205, United States|Investigational Site Number 8400096, Sheffield, Alabama, 35660, United States|Investigational Site Number 8400004, Mesa, Arizona, 85206, United States|Investigational Site Number 8400059, Mesa, Arizona, 85210, United States|Investigational Site Number 8400021, Peoria, Arizona, 85381, United States|Investigational Site Number 8400014, Surprise, Arizona, 85374, United States|Investigational Site Number 8400071, Little Rock, Arkansas, 72211, United States|Investigational Site Number 8400039, Beverly Hills, California, 90211, United States|Investigational Site Number 8400042, Concord, California, 94520, United States|Investigational Site Number 8400089, Fresno, California, 93720, United States|Investigational Site Number 8400006, Huntington Park, California, 90255, United States|Investigational Site Number 8400036, Long Beach, California, 90807, United States|Investigational Site Number 8400073, Los Angeles, California, 90017, United States|Investigational Site Number 8400084, Los Angeles, California, 90022-4302, United States|Investigational Site Number 8400035, Los Gatos, California, 95032, United States|Investigational Site Number 8400043, Northridge, California, 91325, United States|Investigational Site Number 8400025, Sacramento, California, 95821, United States|Investigational Site Number 8400018, San Dimas, California, 91713, United States|Investigational Site Number 8400070, Temecula, California, 92591, United States|Investigational Site Number 8400013, Waterbury, Connecticut, 06708, United States|Investigational Site Number 8400095, Bradenton, Florida, 34209, United States|Investigational Site Number 8400090, Clearwater, Florida, 33756, United States|Investigational Site Number 8400121, Clearwater, Florida, 33756, United States|Investigational Site Number 8400049, Cooper City, Florida, 33024, United States|Investigational Site Number 8400092, Hialeah, Florida, 33012, United States|Investigational Site Number 8400026, Hollywood, Florida, 33024, United States|Investigational Site Number 8400134, Jacksonville, Florida, 32204, United States|Investigational Site Number 8400055, Jacksonville, Florida, 32207-4966, United States|Investigational Site Number 8400056, Jacksonville, Florida, 32216, United States|Investigational Site Number 8400031, Jacksonville, Florida, 32277, United States|Investigational Site Number 8400037, Maitland, Florida, 32751, United States|Investigational Site Number 8400078, Miami, Florida, 33126, United States|Investigational Site Number 8400117, Miami, Florida, 33135, United States|Investigational Site Number 8400119, Miami, Florida, 33135, United States|Investigational Site Number 8400118, Miami, Florida, 33165, United States|Investigational Site Number 8400105, Miami, Florida, 33174, United States|Investigational Site Number 8400120, Miami, Florida, 33176, United States|Investigational Site Number 8400088, North Miami Beach, Florida, 33162, United States|Investigational Site Number 8400106, Opa-locka, Florida, 33054, United States|Investigational Site Number 8400063, Ormond Beach, Florida, 32174, United States|Investigational Site Number 8400087, Palm Harbor, Florida, 34684-3609, United States|Investigational Site Number 8400058, Saint Petersburg, Florida, 33713, United States|Investigational Site Number 8400108, Spring Hill, Florida, 34609, United States|Investigational Site Number 8400051, Tampa, Florida, 33624, United States|Investigational Site Number 8400123, Atlanta, Georgia, 30303, United States|Investigational Site Number 8400076, Roswell, Georgia, 30076, United States|Investigational Site Number 8400033, Honolulu, Hawaii, 96814, United States|Investigational Site Number 8400085, Arlington Heights, Illinois, 60005, United States|Investigational Site Number 8400104, Chicago, Illinois, 60611, United States|Investigational Site Number 8400027, Chicago, Illinois, 60612, United States|Investigational Site Number 8400124, Chicago, Illinois, 60612, United States|Investigational Site Number 8400001, Chicago, Illinois, 60616, United States|Investigational Site Number 8400052, Crystal Lake, Illinois, 60012, United States|Investigational Site Number 8400028, Springfield, Illinois, 62711, United States|Investigational Site Number 8400125, Michigan City, Indiana, 46360, United States|Investigational Site Number 8400098, Valparaiso, Indiana, 46383, United States|Investigational Site Number 8400003, Des Moines, Iowa, 50314, United States|Investigational Site Number 8400081, Topeka, Kansas, 66606, United States|Investigational Site Number 8400041, Louisville, Kentucky, 40213, United States|Investigational Site Number 8400080, Bangor, Maine, 04401, United States|Investigational Site Number 8400002, Flint, Michigan, 48504, United States|Investigational Site Number 8400069, Flint, Michigan, 48532-3447, United States|Investigational Site Number 8400016, Troy, Michigan, 48098, United States|Investigational Site Number 8400023, Saint Cloud, Minnesota, 56303, United States|Investigational Site Number 8400066, Kansas City, Missouri, 64111, United States|Investigational Site Number 8400024, Saint Louis, Missouri, 63136, United States|Investigational Site Number 8400130, Washington, Missouri, 63090, United States|Investigational Site Number 8400045, Omaha, Nebraska, 68198-4100, United States|Investigational Site Number 8400009, Las Vegas, Nevada, 89148, United States|Investigational Site Number 8400101, Albany, New York, 12206, United States|Investigational Site Number 8400061, Laurelton, New York, 11413, United States|Investigational Site Number 8400046, New York, New York, 10029-6501, United States|Investigational Site Number 8400112, Rosedale, New York, 11422, United States|Investigational Site Number 8400062, Smithtown, New York, 11787, United States|Investigational Site Number 8400079, Greenville, North Carolina, 27834-5704, United States|Investigational Site Number 8400020, Morehead City, North Carolina, 28557, United States|Investigational Site Number 8400048, Morehead City, North Carolina, 28557, United States|Investigational Site Number 8400010, Morganton, North Carolina, 28655, United States|Investigational Site Number 8400072, Fargo, North Dakota, 58103, United States|Investigational Site Number 8400038, Cincinnati, Ohio, 45219, United States|Investigational Site Number 8400007, Cincinnati, Ohio, 45241, United States|Investigational Site Number 8400015, Columbus, Ohio, 43210, United States|Investigational Site Number 8400113, Lorain, Ohio, 44053, United States|Investigational Site Number 8400011, Mentor, Ohio, 44060, United States|Investigational Site Number 8400109, Bend, Oregon, 97702, United States|Investigational Site Number 8400047, Beaver, Pennsylvania, 15009, United States|Investigational Site Number 8400019, Greensburg, Pennsylvania, 15601, United States|Investigational Site Number 8400097, Indiana, Pennsylvania, 15701-3578, United States|Investigational Site Number 8400032, Levittown, Pennsylvania, 19056-2404, United States|Investigational Site Number 8400053, Philadelphia, Pennsylvania, 19107, United States|Investigational Site Number 8400012, Pittsburgh, Pennsylvania, 15212, United States|Investigational Site Number 8400064, Anderson, South Carolina, 29621, United States|Investigational Site Number 8400030, Greer, South Carolina, 29651, United States|Investigational Site Number 8400029, Myrtle Beach, South Carolina, 29572, United States|Investigational Site Number 8400040, Memphis, Tennessee, 38163, United States|Investigational Site Number 8400114, Arlington, Texas, 76015, United States|Investigational Site Number 8400067, Corpus Christi, Texas, 78814, United States|Investigational Site Number 8400082, Dallas, Texas, 75231, United States|Investigational Site Number 8400022, El Paso, Texas, 79935, United States|Investigational Site Number 8400099, Houston, Texas, 77043, United States|Investigational Site Number 8400103, Houston, Texas, 77070, United States|Investigational Site Number 8400086, Katy, Texas, 77450, United States|Investigational Site Number 8400100, Mesquite, Texas, 75150, United States|Investigational Site Number 8400094, Plano, Texas, 75093, United States|Investigational Site Number 8400116, San Antonio, Texas, 78224, United States|Investigational Site Number 8400091, Waco, Texas, 76710, United States|Investigational Site Number 8400065, Bountiful, Utah, 84010-7717, United States|Investigational Site Number 8400131, Ogden, Utah, 84405, United States|Investigational Site Number 8400093, Bennington, Vermont, 05201, United States|Investigational Site Number 8400060, South Burlington, Vermont, 05403, United States|Investigational Site Number 8400133, Danville, Virginia, 24541-2834, United States|Investigational Site Number 8400054, Fairfax, Virginia, 22039, United States|Investigational Site Number 8400132, Falls Church, Virginia, 22044, United States|Investigational Site Number 8400034, Manassas, Virginia, 20110, United States|Investigational Site Number 8400050, Norfolk, Virginia, 23510, United States|Investigational Site Number 8400044, Richmond, Virginia, 23235, United States|Investigational Site Number 8400111, Richmond, Virginia, 23249, United States|Investigational Site Number 8400083, Federal Way, Washington, 98003, United States|Investigational Site Number 8400068, Spokane, Washington, 99207, United States|Investigational Site Number 0320016, Buenos Aires, Argentina|Investigational Site Number 0320029, Buenos Aires, Argentina|Investigational Site Number 0320017, Caba, 1120, Argentina|Investigational Site Number 0320002, Caba, C1093AAS, Argentina|Investigational Site Number 0320004, Caba, C1118AAE, Argentina|Investigational Site Number 0320018, Caba, C1119ACN, Argentina|Investigational Site Number 0320025, Caba, C1128AAF, Argentina|Investigational Site Number 0320019, Caba, Argentina|Investigational Site Number 0320027, Capital Federal, C1056ABJ, Argentina|Investigational Site Number 0320015, Capital Federal, C1179AAB, Argentina|Investigational Site Number 0320014, Ciudad Autonoma De Bs.As, C1428DCO, Argentina|Investigational Site Number 0320023, Ciudad Autonoma De Buenos Aire, C1204AAD, Argentina|Investigational Site Number 0320009, Ciudadela, B1702BML, Argentina|Investigational Site Number 0320001, Cordoba, X5000AAX, Argentina|Investigational Site Number 0320008, Coronel Suarez, B7540GHD, Argentina|Investigational Site Number 0320011, Corrientes, W3400AMZ, Argentina|Investigational Site Number 0320028, La Plata, B1900AXI, Argentina|Investigational Site Number 0320006, La Plata, B1906ESC, Argentina|Investigational Site Number 0320024, Mar Del Plata, B7600FZN, Argentina|Investigational Site Number 0320003, Mar Del Plata, B7600, Argentina|Investigational Site Number 0320020, Merlo, B1722COV, Argentina|Investigational Site Number 0320007, Ramos Mejia, B1704ETD, Argentina|Investigational Site Number 0320030, Rosario, S2000CVD, Argentina|Investigational Site Number 0320026, Rosario, S2000DEJ, Argentina|Investigational Site Number 0320012, Salta, 4400, Argentina|Investigational Site Number 0320021, San Miguel De Tucuman, T4000ICL, Argentina|Investigational Site Number 0320013, Santa Fe, S3000FWO, Argentina|Investigational Site Number 0320022, Temperley, 1842, Argentina|Investigational Site Number 0320005, Villa Maria, X5900JKA, Argentina|Investigational Site Number 0360014, Adelaide, 5000, Australia|Investigational Site Number 0360004, Box Hill, 3128, Australia|Investigational Site Number 0360015, Elizabeth Vale, 5112, Australia|Investigational Site Number 0360005, Fitzroy, 3065, Australia|Investigational Site Number 0360018, Fremantle, 6160, Australia|Investigational Site Number 0360007, Fullarton, 5063, Australia|Investigational Site Number 0360002, Gosford, 2250, Australia|Investigational Site Number 0360016, Heidelberg, 3081, Australia|Investigational Site Number 0360010, Herston, 4029, Australia|Investigational Site Number 0360009, Liverpool, 2170, Australia|Investigational Site Number 0360017, Melbourne, 3004, Australia|Investigational Site Number 0360001, Merewether, 2291, Australia|Investigational Site Number 0360012, Oaklands Park, 5046, Australia|Investigational Site Number 0360011, Parkville, 3050, Australia|Investigational Site Number 0360008, Redcliffe, 4020, Australia|Investigational Site Number 0360013, Sherwood, 4075, Australia|Investigational Site Number 0360019, St Leonards, 2065, Australia|Investigational Site Number 0360006, Wollongong, 2500, Australia|Investigational Site Number 0560004, Bonheiden, 2820, Belgium|Investigational Site Number 0560005, Gent, 9000, Belgium|Investigational Site Number 0560003, Kortrijk, 8500, Belgium|Investigational Site Number 0560002, La-Louvière, 7100, Belgium|Investigational Site Number 0560001, Leuven, 3000, Belgium|Investigational Site Number 0760017, Blumenau, 89020-430, Brazil|Investigational Site Number 0760015, Brasilia, 70200-730, Brazil|Investigational Site Number 0760026, Brasilia, 70390-903, Brazil|Investigational Site Number 0760008, Campinas, 13015-001, Brazil|Investigational Site Number 0760005, Campinas, 13060-080, Brazil|Investigational Site Number 0760018, Canoas, 92425-900, Brazil|Investigational Site Number 0760019, Curitiba, 80030-110, Brazil|Investigational Site Number 0760011, Curitiba, 80230-130, Brazil|Investigational Site Number 0760007, Curitiba, 80730-150, Brazil|Investigational Site Number 0760010, Fortaleza, 60115-282, Brazil|Investigational Site Number 0760002, Fortaleza, 60170-320, Brazil|Investigational Site Number 0760004, Fortaleza, 60430-350, Brazil|Investigational Site Number 0760014, Passo Fundo, 99010-180, Brazil|Investigational Site Number 0760025, Porto Alegre, 90020-090, Brazil|Investigational Site Number 0760016, Porto Alegre, 90430-001, Brazil|Investigational Site Number 0760024, Recife, 52051-380, Brazil|Investigational Site Number 0760023, Rio De Janeiro, 22271-100, Brazil|Investigational Site Number 0760001, Sao Jose Do Rio Preto, 15090-000, Brazil|Investigational Site Number 0760012, Sao Jose Dos Campos, 12243-280, Brazil|Investigational Site Number 0760020, Sao Paulo, 01228-200, Brazil|Investigational Site Number 0760013, Sao Paulo, 04038-002, Brazil|Investigational Site Number 0760022, Sao Paulo, 04266-010, Brazil|Investigational Site Number 0760006, Sao Paulo, 05403-000, Brazil|Investigational Site Number 0760009, Sao Paulo, 05403-000, Brazil|Investigational Site Number 0760003, São Paulo, 01.228-000, Brazil|Investigational Site Number 0760021, Vitoria, 29055 450, Brazil|Investigational Site Number 1000015, Blagoevgrad, 2700, Bulgaria|Investigational Site Number 1000008, Dobrich, MULTIPROFILE HOSPITA, Bulgaria|Investigational Site Number 1000013, Gabrovo, 5300, Bulgaria|Investigational Site Number 1000003, Plovdiv, 4002, Bulgaria|Investigational Site Number 1000016, Ruse, 7002, Bulgaria|Investigational Site Number 1000014, Silistra, 7500, Bulgaria|Investigational Site Number 1000007, Smolyan, 4700, Bulgaria|Investigational Site Number 1000011, Sofia, 1233, Bulgaria|Investigational Site Number 1000004, Sofia, 1431, Bulgaria|Investigational Site Number 1000006, Sofia, 1431, Bulgaria|Investigational Site Number 1000012, Sofia, 1632, Bulgaria|Investigational Site Number 1000005, Sofia, 1750, Bulgaria|Investigational Site Number 1000017, Sofia, 1784, Bulgaria|Investigational Site Number 1000001, Stara Zagora, 6000, Bulgaria|Investigational Site Number 1000018, Stara Zagora, 6000, Bulgaria|Investigational Site Number 1240002, Brampton, L6S0C6, Canada|Investigational Site Number 1240013, Burlington, L7M 4Y1, Canada|Investigational Site Number 1240021, Calgary, T2T 5C7, Canada|Investigational Site Number 1240005, Calgary, T2V 4J2, Canada|Investigational Site Number 1240029, Concord, L4K 4M2, Canada|Investigational Site Number 1240004, Edmonton, T5A 4L8, Canada|Investigational Site Number 1240010, Edmonton, T6H 2L4, Canada|Investigational Site Number 1240027, Halifax, B3H 2Y9, Canada|Investigational Site Number 1240023, Hamilton, L8N 3Z5, Canada|Investigational Site Number 1240011, London, N6A 4V2, Canada|Investigational Site Number 1240019, Montreal, H1T 1C8, Canada|Investigational Site Number 1240017, Montreal, H4A 2C6, Canada|Investigational Site Number 1240018, Montreal, H4N 2W2, Canada|Investigational Site Number 1240007, Newmarket, L3Y 5G8, Canada|Investigational Site Number 1240026, Oshawa, L1G 2B9, Canada|Investigational Site Number 1240016, Oshawa, L1J 2K1, Canada|Investigational Site Number 1240006, Ottawa, K1H7W9, Canada|Investigational Site Number 1240022, Quebec, G1G 3Z4, Canada|Investigational Site Number 1240025, Quebec, G1V 4G5, Canada|Investigational Site Number 1240014, Quebec, G1V 4W2, Canada|Investigational Site Number 1240003, Quebec, G1W-4R4, Canada|Investigational Site Number 1240034, Saint-Charles-Borromee, J6E 6J2, Canada|Investigational Site Number 1240032, St-Marc-Des-Carrieres, G0A 4B0, Canada|Investigational Site Number 1240033, St. John'S, A1B 3V6, Canada|Investigational Site Number 1240008, Sudbury, P3E 4H5, Canada|Investigational Site Number 1240031, Surrey, V3V 0C6, Canada|Investigational Site Number 1240028, Toronto, M6G 1M2, Canada|Investigational Site Number 1240015, Trois-Rivieres, G8Z 3R9, Canada|Investigational Site Number 1240001, Vancouver, V5Y 3W2, Canada|Investigational Site Number 1240030, Victoria, V8R 1B2, Canada|Investigational Site Number 1520015, Concepción, 4070566, Chile|Investigational Site Number 1520003, Osorno, 5311092, Chile|Investigational Site Number 1520012, Punta Arenas, 6210490, Chile|Investigational Site Number 1520013, Santiago, 7500571, Chile|Investigational Site Number 1520018, Santiago, 7500588, Chile|Investigational Site Number 1520001, Santiago, 7500710, Chile|Investigational Site Number 1520004, Santiago, 7500710, Chile|Investigational Site Number 1520006, Santiago, 7500739, Chile|Investigational Site Number 1520014, Santiago, 7591047, Chile|Investigational Site Number 1520016, Santiago, 7650568, Chile|Investigational Site Number 1520017, Santiago, 7770086, Chile|Investigational Site Number 1520020, Santiago, 7770086, Chile|Investigational Site Number 1520009, Santiago, 8053095, Chile|Investigational Site Number 1520011, Santiago, 8207257, Chile|Investigational Site Number 1520026, Santiago, 833-0024, Chile|Investigational Site Number 1520010, Santiago, 8330336, Chile|Investigational Site Number 1520007, Santiago, 8380456, Chile|Investigational Site Number 1520021, Santiago, 8900132, Chile|Investigational Site Number 1520022, Santiago, 8910131, Chile|Investigational Site Number 1520002, Santiago, Chile|Investigational Site Number 1520024, Talca, Chile|Investigational Site Number 1520019, Temuco, 4781156, Chile|Investigational Site Number 1520025, Temuco, 4781173, Chile|Investigational Site Number 1520005, Temuco, 4813299, Chile|Investigational Site Number 1520008, Viña Del Mar, Chile|Investigational Site Number 1560019, Beijing, 100034, China|Investigational Site Number 1560001, Beijing, 100037, China|Investigational Site Number 1560002, Beijing, 100044, China|Investigational Site Number 1560003, Beijing, 100730, China|Investigational Site Number 1560032, Beijing, 100730, China|Investigational Site Number 1560012, Changchun, 130021, China|Investigational Site Number 1560023, Changchun, 130021, China|Investigational Site Number 1560034, Changchun, 130033, China|Investigational Site Number 1560022, Changsha, 410013, China|Investigational Site Number 1560021, Chengdu, 610041, China|Investigational Site Number 1560018, Dalian, 116011, China|Investigational Site Number 1560010, Dalian, 116033, China|Investigational Site Number 1560007, Guangzhou, 510080, China|Investigational Site Number 1560016, Haikou, 570102, China|Investigational Site Number 1560033, Hengyang, 421001, China|Investigational Site Number 1560038, Hohhot, 010020, China|Investigational Site Number 1560005, Huai'An, 223300, China|Investigational Site Number 1560009, Jinan, 250013, China|Investigational Site Number 1560037, Jining, China|Investigational Site Number 1560031, Nanchang, 330006, China|Investigational Site Number 1560004, Nanjing, 210008, China|Investigational Site Number 1560006, Shanghai, 200120, China|Investigational Site Number 1560036, Shenyang, 110016, China|Investigational Site Number 1560020, Siping, 136000, China|Investigational Site Number 1560025, Suzhou, 215004, China|Investigational Site Number 1560014, Suzhou, 215006, China|Investigational Site Number 1560026, Taizhou, 317000, China|Investigational Site Number 1560028, Tianjin, 300121, China|Investigational Site Number 1560029, Tianjin, 300211, China|Investigational Site Number 1560024, Wuhan, 430033, China|Investigational Site Number 1560027, Xi'An, 710061, China|Investigational Site Number 1560035, Xinxiang, 453000, China|Investigational Site Number 1560008, Zhenjiang, 212001, China|Investigational Site Number 2030012, Brno, 62500, Czechia|Investigational Site Number 2030002, Brno, 63900, Czechia|Investigational Site Number 2030021, Broumov, 550 01, Czechia|Investigational Site Number 2030017, Humpolec, 396 01, Czechia|Investigational Site Number 2030014, Liberec, 46063, Czechia|Investigational Site Number 2030007, Marianske Lazne, 353 01, Czechia|Investigational Site Number 2030015, Mestec Kralove, 28903, Czechia|Investigational Site Number 2030009, Plzen, 301 00, Czechia|Investigational Site Number 2030016, Praha 10, 10800, Czechia|Investigational Site Number 2030019, Praha 1, 11694, Czechia|Investigational Site Number 2030006, Praha 2, 12808, Czechia|Investigational Site Number 2030005, Praha 4, 14021, Czechia|Investigational Site Number 2030011, Praha 6, 16900, Czechia|Investigational Site Number 2030018, Praha 8, 18100, Czechia|Investigational Site Number 2030010, Revnice, 25230, Czechia|Investigational Site Number 2030020, Slany, 27401, Czechia|Investigational Site Number 2030001, Trutnov, 54101, Czechia|Investigational Site Number 2030008, Vsetin, 75501, Czechia|Investigational Site Number 2080003, Aarhus N, 8200, Denmark|Investigational Site Number 2080005, Aarhus N, 8200, Denmark|Investigational Site Number 2080009, Gentofte, 2900, Denmark|Investigational Site Number 2080004, Herlev, 2730, Denmark|Investigational Site Number 2080008, Hvidovre, 2650, Denmark|Investigational Site Number 2080002, København Nv, 2400, Denmark|Investigational Site Number 2080007, Slagelse, 4200, Denmark|Investigational Site Number 2080006, Svendborg, 5700, Denmark|Investigational Site Number 2330003, Tallinn, 10138, Estonia|Investigational Site Number 2330001, Tallinn, 13419, Estonia|Investigational Site Number 2330002, Tartu, 51014, Estonia|Investigational Site Number 2500003, Corbeil-Essonnes, 91106, France|Investigational Site Number 2500002, La Rochelle Cedex, 17019, France|Investigational Site Number 2500001, Paris Cedex 18, 75877, France|Investigational Site Number 2500005, Paris, 75010, France|Investigational Site Number 2500006, Paris, 75018, France|Investigational Site Number 2500004, Toulouse Cedex 9, 31059, France|Investigational Site Number 2500007, Venissieux, 69200, France|Investigational Site Number 2680004, Batumi, 6010, Georgia|Investigational Site Number 2680001, Kutaisi, Georgia|Investigational Site Number 2680007, Tbilisi, 0159, Georgia|Investigational Site Number 2680005, Tbilisi, 102, Georgia|Investigational Site Number 2680003, Tbilisi, 159, Georgia|Investigational Site Number 2680006, Tbilisi, 159, Georgia|Investigational Site Number 2680002, Tbilisi, Georgia|Investigational Site Number 2760008, Berlin, 12351, Germany|Investigational Site Number 2760005, Essen, 45136, Germany|Investigational Site Number 2760001, Freiburg, 79106, Germany|Investigational Site Number 2760007, Hamburg, 22041, Germany|Investigational Site Number 2760002, Kassel, 34121, Germany|Investigational Site Number 2760006, Leipzig, 04103, Germany|Investigational Site Number 2760003, Münster, 48149, Germany|Investigational Site Number 2760009, Oldenburg In Holstein, 23758, Germany|Investigational Site Number 3000001, Athens, 11527, Greece|Investigational Site Number 3000002, Ioannina, 45500, Greece|Investigational Site Number 3000004, Larissa, 41110, Greece|Investigational Site Number 3000003, Pireas, 18454, Greece|Investigational Site Number 3000005, Thessaloniki, 54629, Greece|Investigational Site Number 3200007, Guatemala, 01001, Guatemala|Investigational Site Number 3200013, Guatemala, 01010, Guatemala|Investigational Site Number 3200001, Guatemala, 01014, Guatemala|Investigational Site Number 3200002, Guatemala, 1010, Guatemala|Investigational Site Number 3200009, Guatemala, 1010, Guatemala|Investigational Site Number 3200010, Guatemala, Guatemala|Investigational Site Number 3200006, Quetzaltenango, 09001, Guatemala|Investigational Site Number 3200014, Quetzaltenango, 09001, Guatemala|Investigational Site Number 3200004, Quetzaltenango, 9011, Guatemala|Investigational Site Number 3480017, Budapest, 1027, Hungary|Investigational Site Number 3480004, Budapest, 1042, Hungary|Investigational Site Number 3480011, Budapest, 1096, Hungary|Investigational Site Number 3480001, Budapest, 1122, Hungary|Investigational Site Number 3480010, Budapest, 1125, Hungary|Investigational Site Number 3480012, Budapest, 1134, Hungary|Investigational Site Number 3480016, Budapest, 1145, Hungary|Investigational Site Number 3480018, Budapest, 1204, Hungary|Investigational Site Number 3480006, Békéscsaba, 5600, Hungary|Investigational Site Number 3480002, Debrecen, 4032, Hungary|Investigational Site Number 3480008, Debrecen, 4032, Hungary|Investigational Site Number 3480013, Kaposvár, 7400, Hungary|Investigational Site Number 3480014, Nyíregyháza, 4400, Hungary|Investigational Site Number 3480015, Nyíregyháza, 4400, Hungary|Investigational Site Number 3480003, Szekesfehervar, 8000, Hungary|Investigational Site Number 3480007, Zalaegerszeg, 8900, Hungary|Investigational Site Number 3560025, Ahmedabad, 380060, India|Investigational Site Number 3560040, Aurangabad, 431003, India|Investigational Site Number 3560010, Bangalore, 560 034, India|Investigational Site Number 3560026, Bangalore, 560 054., India|Investigational Site Number 3560005, Belgaum, 590010, India|Investigational Site Number 3560008, Bengaluru, 560017, India|Investigational Site Number 3560022, Chandigarh, 160062, India|Investigational Site Number 3560003, Gurgaon, 122001, India|Investigational Site Number 3560004, Gurgaon, 122001, India|Investigational Site Number 3560018, Hyderabad, 500001, India|Investigational Site Number 3560001, Hyderabad, 500012, India|Investigational Site Number 3560007, Hyderabad, 500063, India|Investigational Site Number 3560002, Jaipur, 302017, India|Investigational Site Number 3560024, Kochi, India|Investigational Site Number 3560016, Kolkata, 700027, India|Investigational Site Number 3560030, Kozhikode, 673008, India|Investigational Site Number 3560006, Ludhiana, 141008, India|Investigational Site Number 3560027, Mangalore, 575002, India|Investigational Site Number 3560028, Mangalore, 575018, India|Investigational Site Number 3560017, Mumbai, India|Investigational Site Number 3560037, Mysore, 570015, India|Investigational Site Number 3560013, Nagpur, 440009, India|Investigational Site Number 3560014, Nagpur, 440010, India|Investigational Site Number 3560021, Nashik, 42003, India|Investigational Site Number 3560041, New Delhi, 110 029, India|Investigational Site Number 3560034, New Delhi, 110002, India|Investigational Site Number 3560019, Pune, 411001, India|Investigational Site Number 3560035, Pune, 411004, India|Investigational Site Number 3560042, Pune, 411004, India|Investigational Site Number 3560038, Pune, 411010, India|Investigational Site Number 3560012, Pune, 411019, India|Investigational Site Number 3560043, Varanasi, 221 005, India|Investigational Site Number 3560020, Vellore, 632004, India|Investigational Site Number 3560015, Wardha, 442004, India|Investigational Site Number 3760008, Beer Sheva, 84101, Israel|Investigational Site Number 3760005, Haifa, 31048, Israel|Investigational Site Number 3760007, Haifa, 31096, Israel|Investigational Site Number 3760001, Jerusalem, 91031, Israel|Investigational Site Number 3760002, Jerusalem, 91120, Israel|Investigational Site Number 3760004, Nahariya, 22100, Israel|Investigational Site Number 3760003, Tel Aviv, 64239, Israel|Investigational Site Number 3760006, Tel Hashomer, 52621, Israel|Investigational Site Number 3800006, Catanzaro, 88100, Italy|Investigational Site Number 3800010, Catanzaro, 88100, Italy|Investigational Site Number 3800009, Chieri, 10023, Italy|Investigational Site Number 3800007, Livorno, 57123, Italy|Investigational Site Number 3800002, Milano, 20132, Italy|Investigational Site Number 3800008, Milano, 20145, Italy|Investigational Site Number 3800005, Orbassano, 10043, Italy|Investigational Site Number 3800011, Ravenna, 48100, Italy|Investigational Site Number 3800004, Roma, 00133, Italy|Investigational Site Number 3800001, Verona, 37126, Italy|Investigational Site Number 4100011, Bucheon-Si, 14647, Korea, Republic of|Investigational Site Number 4100005, Busan, 49201, Korea, Republic of|Investigational Site Number 4100007, Gwangju, 61469, Korea, Republic of|Investigational Site Number 4100001, Incheon, 22332, Korea, Republic of|Investigational Site Number 4100002, Seongnam-Si, 13620, Korea, Republic of|Investigational Site Number 4100003, Seoul, 03080, Korea, Republic of|Investigational Site Number 4100006, Seoul, 03722, Korea, Republic of|Investigational Site Number 4100008, Seoul, 05505, Korea, Republic of|Investigational Site Number 4100004, Seoul, 06351, Korea, Republic of|Investigational Site Number 4100010, Uijeongbu-Si, 11765, Korea, Republic of|Investigational Site Number 4280004, Daugavpils, LV-5417, Latvia|Investigational Site Number 4280002, Liepāja, LV3414, Latvia|Investigational Site Number 4280007, Ogre, LV-5001, Latvia|Investigational Site Number 4280006, Riga, LV-1002, Latvia|Investigational Site Number 4280001, Riga, LV-1011, Latvia|Investigational Site Number 4280005, Riga, LV-1038, Latvia|Investigational Site Number 4280003, Sigulda, LV-2150, Latvia|Investigational Site Number 4400006, Kaunas, 49449, Lithuania|Investigational Site Number 4400003, Kaunas, 51270, Lithuania|Investigational Site Number 4400009, Kaunas, LT-50161, Lithuania|Investigational Site Number 4400008, Kedainiai, LT-57164, Lithuania|Investigational Site Number 4400004, Klaipeda, 92111, Lithuania|Investigational Site Number 4400002, Klaipeda, LT-92304, Lithuania|Investigational Site Number 4400007, Ukmerge, 20184, Lithuania|Investigational Site Number 4400005, Utena, LT-28151, Lithuania|Investigational Site Number 4400001, Vilnius, 08661, Lithuania|Investigational Site Number 4840009, Actopan, 42500, Mexico|Investigational Site Number 4840013, Aguascalientes, 20230, Mexico|Investigational Site Number 4840019, Aguascalientes, 20230, Mexico|Investigational Site Number 4840018, Cdmx, 06760, Mexico|Investigational Site Number 4840005, Celaya, 38000, Mexico|Investigational Site Number 4840002, Cuernavaca, 62250, Mexico|Investigational Site Number 4840025, Distrito Federal, 07760, Mexico|Investigational Site Number 4840007, Durango, 34000, Mexico|Investigational Site Number 4840023, Durango, 34080, Mexico|Investigational Site Number 4840033, Guadalajara, 44150, Mexico|Investigational Site Number 4840024, Guadalajara, 44160, Mexico|Investigational Site Number 4840003, Guadalajara, 44210, Mexico|Investigational Site Number 4840011, Guadalajara, 44210, Mexico|Investigational Site Number 4840027, Guadalajara, 44280, Mexico|Investigational Site Number 4840004, Guadalajara, 44600, Mexico|Investigational Site Number 4840010, Guadalajara, 44650, Mexico|Investigational Site Number 4840030, Guadalajara, Mexico|Investigational Site Number 4840034, Merida, 97070, Mexico|Investigational Site Number 4840021, Monterrey, 64020, Mexico|Investigational Site Number 4840020, Monterrey, 64060, Mexico|Investigational Site Number 4840001, Monterrey, 64460, Mexico|Investigational Site Number 4840028, Mérida, 72129, Mexico|Investigational Site Number 4840014, Queretaro, 76000, Mexico|Investigational Site Number 4840015, Toluca, 50130, Mexico|Investigational Site Number 4840008, Veracruz, 91910, Mexico|Investigational Site Number 4840016, Xalapa, 91193, Mexico|Investigational Site Number 4840026, Zapopan, 45116, Mexico|Investigational Site Number 5280004, Almelo, 7609 PP, Netherlands|Investigational Site Number 5280001, Groningen, 9728 NT, Netherlands|Investigational Site Number 5280003, Hoogeveen, 7909 AA, Netherlands|Investigational Site Number 5280005, Meppel, 7943 KA, Netherlands|Investigational Site Number 5280002, Rotterdam, 3045 PM, Netherlands|Investigational Site Number 5540014, Auckland, 1023, New Zealand|Investigational Site Number 5540006, Birkenhead, 0626, New Zealand|Investigational Site Number 5540009, Birkenhead, 0626, New Zealand|Investigational Site Number 5540002, Christchurch, 8011, New Zealand|Investigational Site Number 5540003, Christchurch, New Zealand|Investigational Site Number 5540012, Christchurch, New Zealand|Investigational Site Number 5540007, Dunedin, 9016, New Zealand|Investigational Site Number 5540016, Hamilton, 3240, New Zealand|Investigational Site Number 5540013, New Plymouth, New Zealand|Investigational Site Number 5540015, Palmerston North, 4414, New Zealand|Investigational Site Number 5540005, Rotorua, 3010, New Zealand|Investigational Site Number 5540010, Takapuna, 1309, New Zealand|Investigational Site Number 5540008, Tauranga, 3001, New Zealand|Investigational Site Number 5540011, Tauranga, 3001, New Zealand|Investigational Site Number 5540004, Wellington, 6021, New Zealand|Investigational Site Number 8070003, Skopje, 1000, North Macedonia|Investigational Site Number 8070005, Struga, 6330, North Macedonia|Investigational Site Number 8070001, Tetovo, 1200, North Macedonia|Investigational Site Number 8070004, Tetovo, 1200, North Macedonia|Investigational Site Number 5780005, Hamar, 2317, Norway|Investigational Site Number 5780001, Hønefoss, 3515, Norway|Investigational Site Number 5780003, Oslo, 0514, Norway|Investigational Site Number 5780002, Oslo, 373, Norway|Investigational Site Number 5780004, Skedsmokorset, 2020, Norway|Investigational Site Number 6040004, Arequipa, Peru|Investigational Site Number 6040006, Callao, CALLAO 02, Peru|Investigational Site Number 6040009, Callao, Peru|Investigational Site Number 6040024, Chancay, Peru|Investigational Site Number 6040005, Chiclayo, Peru|Investigational Site Number 6040010, Cuzco, Peru|Investigational Site Number 6040014, Lima Lima, Lima 01, Peru|Investigational Site Number 6040001, Lima, 09, Peru|Investigational Site Number 6040025, Lima, 15135, Peru|Investigational Site Number 6040016, Lima, LIMA 01, Peru|Investigational Site Number 6040020, Lima, LIMA 14, Peru|Investigational Site Number 6040013, Lima, Lima 17, Peru|Investigational Site Number 6040023, Lima, LIMA 27, Peru|Investigational Site Number 6040007, Lima, Lima 29, Peru|Investigational Site Number 6040019, Lima, LIMA 31, Peru|Investigational Site Number 6040022, Lima, LIMA 32, Peru|Investigational Site Number 6040012, Lima, Lima 41, Peru|Investigational Site Number 6040017, Lima, Peru|Investigational Site Number 6040011, Piura, 20000, Peru|Investigational Site Number 6040002, Trujillo, Peru|Investigational Site Number 6160027, Bialystok, 15-276, Poland|Investigational Site Number 6160011, Bialystok, 15-435, Poland|Investigational Site Number 6160029, Bydgoszcz, 85-079, Poland|Investigational Site Number 6160030, Bydgoszcz, 85-231, Poland|Investigational Site Number 6160006, Bydgoszcz, 85-822, Poland|Investigational Site Number 6160018, Bytom, 41-902, Poland|Investigational Site Number 6160002, Czeladz, 41-250, Poland|Investigational Site Number 6160003, Gdynia, 81-394, Poland|Investigational Site Number 6160005, Gdynia, 81-472, Poland|Investigational Site Number 6160008, Grodzisk Mazowiecki, 05-825, Poland|Investigational Site Number 6160031, Grodzisk Mazowiecki, 05-825, Poland|Investigational Site Number 6160023, Katowice, 40-611, Poland|Investigational Site Number 6160026, Katowice, 40-748, Poland|Investigational Site Number 6160022, Kielce, 25-525, Poland|Investigational Site Number 6160019, Krakow, 31-135, Poland|Investigational Site Number 6160024, Krakow, 31-261, Poland|Investigational Site Number 6160010, Krakow, 31-548, Poland|Investigational Site Number 6160016, Lodz, 90-242, Poland|Investigational Site Number 6160013, Lodz, 91-347, Poland|Investigational Site Number 6160015, Lodz, Poland|Investigational Site Number 6160007, Lublin, 20-044, Poland|Investigational Site Number 6160033, Poznan, 60-589, Poland|Investigational Site Number 6160021, Pulawy, 24-100, Poland|Investigational Site Number 6160028, Staszow, 28-200, Poland|Investigational Site Number 6160020, Torun, 87-100, Poland|Investigational Site Number 6160014, Warszawa, 00-631, Poland|Investigational Site Number 6160025, Warszawa, 02-005, Poland|Investigational Site Number 6160001, Warszawa, 02-097, Poland|Investigational Site Number 6160004, Warszawa, 02-507, Poland|Investigational Site Number 6160012, Wroclaw, 52-416, Poland|Investigational Site Number 6160017, Zabrze, 41-800, Poland|Investigational Site Number 6160032, Zamosc, 22-400, Poland|Investigational Site Number 6200004, Almada, 2801-951, Portugal|Investigational Site Number 6200005, Caldas Da Rainha, 2500-176, Portugal|Investigational Site Number 6200009, Carnaxide, 2790-134, Portugal|Investigational Site Number 6200002, Coimbra, 3000-075, Portugal|Investigational Site Number 6200008, Leiria, 2410-197, Portugal|Investigational Site Number 6200001, Lisboa, 1250, Portugal|Investigational Site Number 6200007, Loures, 2674-514, Portugal|Investigational Site Number 6200003, Porto, 4099-001, Portugal|Investigational Site Number 8400122, San Juan, 00917, Puerto Rico|Investigational Site Number 6420008, Bacau, 600154, Romania|Investigational Site Number 6420005, Baia Mare, Maramures, 430222, Romania|Investigational Site Number 6420009, Brasov, 500097, Romania|Investigational Site Number 6420013, Bucuresti, 010507, Romania|Investigational Site Number 6420014, Bucuresti, 010627, Romania|Investigational Site Number 6420012, Bucuresti, 020475, Romania|Investigational Site Number 6420011, Bucuresti, 022441, Romania|Investigational Site Number 6420002, Craiova, 200349, Romania|Investigational Site Number 6420003, Oradea, 410159, Romania|Investigational Site Number 6420004, Oradea, 410469, Romania|Investigational Site Number 6420010, Ploiesti, 100561, Romania|Investigational Site Number 6420001, Targoviste, Dambovita, 130095, Romania|Investigational Site Number 6420006, Targu Mures, Mures, 540142, Romania|Investigational Site Number 6420007, Targu Mures, Mures, 540142, Romania|Investigational Site Number 6430028, Kaliningrad, 236035, Russian Federation|Investigational Site Number 6430018, Kazan, 420101, Russian Federation|Investigational Site Number 6430001, Kemerovo, 650002, Russian Federation|Investigational Site Number 6430035, Kemerovo, 650070, Russian Federation|Investigational Site Number 6430025, Krasnodar, 350042, Russian Federation|Investigational Site Number 6430040, Krasnodar, 350063, Russian Federation|Investigational Site Number 6430010, Krasnodar, 350086, Russian Federation|Investigational Site Number 6430015, Moscow, 101990, Russian Federation|Investigational Site Number 6430016, Moscow, 101990, Russian Federation|Investigational Site Number 6430046, Moscow, 105554, Russian Federation|Investigational Site Number 6430003, Moscow, 117292, Russian Federation|Investigational Site Number 6430036, Moscow, 119192, Russian Federation|Investigational Site Number 6430005, Moscow, 119991, Russian Federation|Investigational Site Number 6430039, Moscow, 119991, Russian Federation|Investigational Site Number 6430021, Moscow, 121309, Russian Federation|Investigational Site Number 6430002, Moscow, 121374, Russian Federation|Investigational Site Number 6430020, Moscow, 125284, Russian Federation|Investigational Site Number 6430024, Moscow, 127644, Russian Federation|Investigational Site Number 6430033, Nizhniy Novgorod, 603005, Russian Federation|Investigational Site Number 6430037, Novosibirsk, 630005, Russian Federation|Investigational Site Number 6430034, Novosibirsk, 630089, Russian Federation|Investigational Site Number 6430007, Perm, 614077, Russian Federation|Investigational Site Number 6430019, Rostov-Na-Donu, 344068, Russian Federation|Investigational Site Number 6430012, Saint-Petersburg, 192242, Russian Federation|Investigational Site Number 6430044, Saint-Petersburg, 197110, Russian Federation|Investigational Site Number 6430045, Saint-Petersburg, 197110, Russian Federation|Investigational Site Number 6430043, Saint-Petersburg, 198205, Russian Federation|Investigational Site Number 6430009, Saratov, 410028, Russian Federation|Investigational Site Number 6430013, Saratov, 410028, Russian Federation|Investigational Site Number 6430042, Saratov, 410039, Russian Federation|Investigational Site Number 6430026, Sochi, 354057, Russian Federation|Investigational Site Number 6430027, Sochi, 354057, Russian Federation|Investigational Site Number 6430041, St-Petersburg, 193312, Russian Federation|Investigational Site Number 6430006, St-Petersburg, 194044, Russian Federation|Investigational Site Number 6430008, St-Petersburg, 194044, Russian Federation|Investigational Site Number 6430030, St-Petersburg, 194044, Russian Federation|Investigational Site Number 6430014, St-Petersburg, 197341, Russian Federation|Investigational Site Number 6430017, St-Petersburg, 197341, Russian Federation|Investigational Site Number 6430004, St-Petersburg, 199106, Russian Federation|Investigational Site Number 6430011, Tomsk, 634012, Russian Federation|Investigational Site Number 6430038, Tomsk, 634050, Russian Federation|Investigational Site Number 6430032, Tyumen, 625000, Russian Federation|Investigational Site Number 6430023, Vladimir, 600020, Russian Federation|Investigational Site Number 6430022, Vladimir, 600023, Russian Federation|Investigational Site Number 6430031, Yaroslavl, 150002, Russian Federation|Investigational Site Number 6880002, Belgrade, 11000, Serbia|Investigational Site Number 6880003, Belgrade, 11000, Serbia|Investigational Site Number 6880004, Belgrade, 11000, Serbia|Investigational Site Number 6880005, Kragujevac, 34000, Serbia|Investigational Site Number 6880001, Nis, 18000, Serbia|Investigational Site Number 6880006, Nis, 18000, Serbia|Investigational Site Number 6880007, Nis, 18000, Serbia|Investigational Site Number 7030006, Bardejov, 085 01, Slovakia|Investigational Site Number 7030012, Bratislava, 813 69, Slovakia|Investigational Site Number 7030011, Kosice, 040 01, Slovakia|Investigational Site Number 7030001, Lubochna, 034 91, Slovakia|Investigational Site Number 7030008, Lucenec, 984 39, Slovakia|Investigational Site Number 7030009, Lucenec, 98401, Slovakia|Investigational Site Number 7030010, Lucenec, 98401, Slovakia|Investigational Site Number 7030004, Moldava Nad Bodvou, 04525, Slovakia|Investigational Site Number 7030013, Presov, 080 01, Slovakia|Investigational Site Number 7030003, Roznava, 04801, Slovakia|Investigational Site Number 7030002, Sabinov, 083 01, Slovakia|Investigational Site Number 7030007, Svidnik, 089 01, Slovakia|Investigational Site Number 7100005, Brits, 0250, South Africa|Investigational Site Number 7100009, Cape Town, 7530, South Africa|Investigational Site Number 7100006, Cape Town, 7570, South Africa|Investigational Site Number 7100001, Parow, 7500, South Africa|Investigational Site Number 7100012, Pinelands, 7405, South Africa|Investigational Site Number 7100011, Pretoria, 0002, South Africa|Investigational Site Number 7100014, Pretoria, 0083, South Africa|Investigational Site Number 7100008, Pretoria, 0157, South Africa|Investigational Site Number 7100010, Rivonia, 2128, South Africa|Investigational Site Number 7100007, Soweto, 1818, South Africa|Investigational Site Number 7100002, Umkomaas, 4170, South Africa|Investigational Site Number 7100013, Vosloorus, 1475, South Africa|Investigational Site Number 7100003, Western Cape, 7130, South Africa|Investigational Site Number 7240003, Almería, 04120, Spain|Investigational Site Number 7240014, Barcelona, 08035, Spain|Investigational Site Number 7240011, Barcelona, 08041, Spain|Investigational Site Number 7240009, Córdoba, 14004, Spain|Investigational Site Number 7240024, El Puerto De Santa Maria, 11500, Spain|Investigational Site Number 7240016, Granada, 18016, Spain|Investigational Site Number 7240015, La Coruña, 15006, Spain|Investigational Site Number 7240001, Madrid, 28023, Spain|Investigational Site Number 7240019, Madrid, 28034, Spain|Investigational Site Number 7240006, Madrid, 28040, Spain|Investigational Site Number 7240010, Madrid, 28046, Spain|Investigational Site Number 7240020, Madrid, 28046, Spain|Investigational Site Number 7240025, Sabadell, 08208, Spain|Investigational Site Number 7240023, Sanlúcar De Barrameda, 11540, Spain|Investigational Site Number 7240013, Santa Cruz De Tenerife, 38320, Spain|Investigational Site Number 7240007, Santiago De Compostela, 15706, Spain|Investigational Site Number 7240026, Sevilla, 41014, Spain|Investigational Site Number 7240012, Sevilla, 41071, Spain|Investigational Site Number 7240004, Valencia, 46010, Spain|Investigational Site Number 7240002, Vigo, 36312, Spain|Investigational Site Number 7240022, Villamartín, 11650, Spain|Investigational Site Number 7240008, Zaragoza, 50009, Spain|Investigational Site Number 7520007, Falun, 791 82, Sweden|Investigational Site Number 7520005, Lund, 221 85, Sweden|Investigational Site Number 7520004, Mölndal, 43180, Sweden|Investigational Site Number 7520003, Rättvik, 79530, Sweden|Investigational Site Number 7520008, Stockholm, 112 21, Sweden|Investigational Site Number 7520002, Stockholm, 118 83, Sweden|Investigational Site Number 7520006, Stockholm, 14186, Sweden|Investigational Site Number 7520001, Uppsala, 751 85, Sweden|Investigational Site Number 7560001, Olten, 4600, Switzerland|Investigational Site Number 7560002, Zollikerberg, 8125, Switzerland|Investigational Site Number 1580005, Hsinchu, 30071, Taiwan|Investigational Site Number 1580008, Kaohsiung, 807, Taiwan|Investigational Site Number 1580004, Linkou, Taiwan|Investigational Site Number 1580006, Taichung, 40447, Taiwan|Investigational Site Number 1580002, Tainan, 704, Taiwan|Investigational Site Number 1580007, Tainan, 710, Taiwan|Investigational Site Number 1580003, Taipei, 100, Taiwan|Investigational Site Number 1580001, Taipei, 112, Taiwan|Investigational Site Number 7920018, Antalya, 07070, Turkey|Investigational Site Number 7920010, Aydın, 09100, Turkey|Investigational Site Number 7920004, Corum, 19200, Turkey|Investigational Site Number 7920016, Gaziantep, 27310, Turkey|Investigational Site Number 7920011, Istanbul, 34034, Turkey|Investigational Site Number 7920009, Istanbul, 34390, Turkey|Investigational Site Number 7920001, Istanbul, Turkey|Investigational Site Number 7920007, Istanbul, Turkey|Investigational Site Number 7920017, Istanbul, Turkey|Investigational Site Number 7920003, Izmir, 35340, Turkey|Investigational Site Number 7920013, Kayseri, 38039, Turkey|Investigational Site Number 7920014, Kocaeli, 41380, Turkey|Investigational Site Number 7920005, Kutahya, Turkey|Investigational Site Number 7920015, Malatya, Turkey|Investigational Site Number 7920008, Mersin, 33169, Turkey|Investigational Site Number 7920002, Sivas, 58140, Turkey|Investigational Site Number 8040020, Dnipro, 49005, Ukraine|Investigational Site Number 8040006, Dnipro, 49600, Ukraine|Investigational Site Number 8040009, Ivano-Frankivsk, 76000, Ukraine|Investigational Site Number 8040012, Ivano-Frankivsk, 76018, Ukraine|Investigational Site Number 8040021, Kharkiv, 61039, Ukraine|Investigational Site Number 8040011, Kharkiv, 61058, Ukraine|Investigational Site Number 8040008, Kharkiv, 61166, Ukraine|Investigational Site Number 8040002, Kiev, 02091, Ukraine|Investigational Site Number 8040024, Kiev, 02660, Ukraine|Investigational Site Number 8040003, Kyiv, 03049, Ukraine|Investigational Site Number 8040015, Kyiv, 03115, Ukraine|Investigational Site Number 8040019, Kyiv, 04050, Ukraine|Investigational Site Number 8040010, Kyiv, 04114, Ukraine|Investigational Site Number 8040026, Kyiv, Ukraine|Investigational Site Number 8040023, Lutsk, 43005, Ukraine|Investigational Site Number 8040025, Lutsk, 43024, Ukraine|Investigational Site Number 8040022, Lviv, 79011, Ukraine|Investigational Site Number 8040001, Ternopil, 46000, Ukraine|Investigational Site Number 8040016, Vinnitsya, 21018, Ukraine|Investigational Site Number 8040007, Vinnitsya, 21100, Ukraine|Investigational Site Number 8040004, Vinnytsya, 21001, Ukraine|Investigational Site Number 8040018, Zhytomyr, Ukraine|Investigational Site Number 8260003, Belfast, BT12 6BA, United Kingdom|Investigational Site Number 8260007, Chippenham, SN14 6GT, United Kingdom|Investigational Site Number 8260009, Davyhulme, Manchester, M41 5SL, United Kingdom|Investigational Site Number 8260010, Glasgow, G21 3UW, United Kingdom|Investigational Site Number 8260004, Hayle, TR27 5DT, United Kingdom|Investigational Site Number 8260011, Inverness, IV2 3UJ, United Kingdom|Investigational Site Number 8260002, Ipswich, IP4 5PD, United Kingdom|Investigational Site Number 8260006, Maidstone, ME16 9QQ, United Kingdom|Investigational Site Number 8260001, Swansea, SA2 8PP, United Kingdom
URL: https://clinicaltrials.gov/show/NCT03315143

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress