| Outcome Measures: |
Primary: Change from Baseline plasma NGAL levels at 12months, Elisa, 12months | Secondary: Change from baseline vascular calcification at 12months, Coronary calcification scores (CACS) from serial computed tomographic images with the Agatston method is used to evaluate cardio-vascular calcification, 1 point=130\~199HU；2 points=200\~299HU；3 points =300\~399HU；4 points≥400HU. Abdominal aortic calcification score (AACS) is measured by Kauppila method from lateral dual-energy X-ray absorptiometry spine, 0-3 points. Anterior chest radiographs is used to perform simple calcification scores for aortic arch knob, 0-100%. Higher scores mean a worse outcome., 12months | Other: Change from baseline Chronic Kidney Disease-Mineral and Bone Disorder associated laboratory tests at 12months, Serum calcium and phosphorus are analyzed by Beckman automatic biochemical analyzer in our laboratory center. Blood iPTH measured by ELISA., 12months|Change from baseline bone density tests at 12months, Quantitative computed tomography (QCT) measurements are performed at the lumbar spine (mean of L 1 and L 2 entire vertebral bodies, excluding posterior processes) and hip., 12months
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