| Trial ID: | L1088 |
| Source ID: | NCT00244530
|
| Associated Drug: |
Nifedipine
|
| Title: |
Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Kidney Failure, Chronic|Coronary Artery Disease
|
| Interventions: |
DRUG: Nifedipine
|
| Outcome Measures: |
Primary: Primary efficacy endpoint is change in renal function, evaluated by 51Cr-EDTA clearance between 24 hours pre open-heart surgery and 48 hours post open-heart surgery. Sample size is 20, ten in each group. | Secondary: Change in renal function after open-heart surgery, as measured by cimetidine refined serum creatinine clearance with measurements preoperatively and 2-6 hours, 20-24 hours and 44-48 hours postoperatively. Need for dialysis post-operatively.
|
| Sponsor/Collaborators: |
Sponsor: University of Oslo School of Pharmacy
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
20
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
|
| Start Date: |
2001-06
|
| Completion Date: |
2005-10
|
| Results First Posted: |
|
| Last Update Posted: |
2006-12-22
|
| Locations: |
Rikshospitalet University Hospital, Oslo, 0027, Norway
|
| URL: |
https://clinicaltrials.gov/show/NCT00244530
|
