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Clinical Trial Details

Trial ID: L0125
Source ID: NCT03865407
Associated Drug: Allopurinol
Title: Uric Acid Reduction as a Novel Treatment for Pediatric Chronic Kidney Disease
Acronym:
Status: TERMINATED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT03865407/results
Conditions: Hyperuricemia|Chronic Kidney Diseases
Interventions: DRUG: Allopurinol
Outcome Measures: Primary: eGFR Change, Change in Cys-C eGFR over time, The difference in Cystatin C eGFR between baseline and 6 months will be measured|eGFR Change, Change in Creatinine eGFR over time, The difference in Creatinine eGFR between baseline and 6 months will be measured | Secondary: Serum Uric Acid Change, Change in Serum Uric Acid, The difference in Serum Uric Acid between baseline and 6 months will be measured|Systolic Blood Pressure, Change in systolic blood pressure, The difference in clinic systolic blood pressure between baseline and 6 months will be measured|Diastolic Blood Pressure, Change in diastolic blood pressure, The difference in clinic diastolic blood pressure between baseline and 6 months will be measured | Other: Serum High Sensitivity C-reactive Protein (Hs-CRP), Compare the mean difference of serum hs-CRP from baseline to 6 months between groups, Serum hs-CRP will be measured at baseline and 6 months|Interleukin 18, Change in interleukin 18, Serum interleukin 18 will be measured at baseline, 3 months, and 6 months|Serum Nlrp3, Change in serum Nlrp3, Serum Nlrp3 will be measured at baseline, 3 months, and 6 months|Urine Neutrophil Gelatinase-associated Lipocalin (NGAL), Change in urine NGAL, Urine NGAL will be measured at baseline, 3 months, and 6 months|Urine Endothelin-1 (ET-1), Change in urine ET-1, Urine ET-1 will be measured at baseline, 3 months, and 6 months|Urine Kidney Injury Molecule-1 (KIM-1), Change in urine KIM-1, Urine KIM-1 will be measured at baseline, 3 months, and 6 months|Urine N-acetyl-Beta-D-Glucosaminidase (NAG), Change in urine NAG, Urine NAG will be measured at baseline, 3 months, and 6 months
Sponsor/Collaborators: Sponsor: Virginia Commonwealth University
Gender: ALL
Age: CHILD, ADULT
Phases: PHASE2
Enrollment: 17
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2019-03-10
Completion Date: 2020-10-07
Results First Posted: 2021-05-27
Last Update Posted: 2021-05-27
Locations: Virginia Commonwealth University, Richmond, Virginia, 23298, United States
URL: https://clinicaltrials.gov/show/NCT03865407