| Outcome Measures: |
Primary: Change from Baseline in Kidney Oxygenation in Participants With or Without T2D, Blood oxygenation-level dependent magnetic resonance imaging (BOLD MRI), Baseline, Week 52 | Secondary: Change from Baseline in Kidney Oxygenation in Participants with T2D (BOLD MRI), Baseline, Week 52|Change from Baseline in Kidney Oxygenation in Participants without T2D (BOLD MRI), Baseline, Week 52|Percent Change from Baseline in Body Weight, Baseline, Week 52|Percent Change from Baseline in Renal Sinus Fat Content (MRI), Baseline, Week 52|Percent Change from Baseline in Renal Fat Content (MRI Proton Density Fat Fraction), Baseline, Week 52|Percent Change from Baseline in Renal Blood Flow (Phase-Contrast MRI), Baseline, Week 52|Change from Baseline in Apparent Diffusion Coefficient (ADC) MRI, Baseline, Week 52|Change from Baseline in Glomerular Filtration Rate (GFR) Iohexol Clearance in Milliliter/Minute/Square Meter (ml/min/m²), Baseline, Week 52|Change from Baseline in 24-hour Urinary Albumin Excretion (UAE) in Milligram/24 Hours (mg/24h), Baseline, Week 52|Percent Change from Baseline in Urine Albumin-to-Creatine Ratio (UACR), Baseline, Week 52
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| Locations: |
Valley Clinical Trials, Inc., Northridge, California, 91325, United States|University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, United States|Kidney Associates of Colorado, Denver, Colorado, 80210, United States|American Health Network of Indiana, LLC - Avon, Avon, Indiana, 46123, United States|American Health Network of Indiana, LLC - Greenfield, Greenfield, Indiana, 46140, United States|Indiana University Health University Hospital, Indianapolis, Indiana, 46202, United States|American Health Network of Indiana, LLC - Muncie, Muncie, Indiana, 47304, United States|Arcturus Healthcare , PLC, Troy Internal Medicine Research Division, Troy, Michigan, 48098, United States|University of Washington Medical Center - Montlake, Seattle, Washington, 98195, United States|Providence Medical Research Center - Spokane, Spokane, Washington, 99204, United States|Zentrum für klinische Studien Dr Hanusch Gmbh, Vienna, Wien, 1060, Austria|Klinik Landstraße, Wien, 1030, Austria|Klinik Hietzing, Wien, 1130, Austria|LMC Clinical Research Inc. (Barrie), Barrie, Ontario, L4N 7L3, Canada|LMC Clinical Research Inc. (Thornhill), Concord, Ontario, L4K 4M2, Canada|Toronto General Hospital, Toronto, Ontario, M5G 2C4, Canada|Fadia El Boreky Medicine, Waterloo, Ontario, N2J 1C4, Canada|Centre intégré universitaire de santé et de services sociaux de l'Estrie Centre Hospitalier Universitaire -T, Sherbrooke, Quebec, J1H 5N4, Canada|Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland, 8200, Denmark|Health Pharma Professional Research S.A. de C.V:, Ciudad de México, Distrito Federal, 03100, Mexico|Grupo Medico Camino Sc, Mexico City, Distrito Federal, 03310, Mexico|Caimed Investigacion En Salud S.A. de C.V., Mexico City, Distrito Federal, 06760, Mexico|AGNI Research and Assessment S.C., Cuernavaca, Morelos, 62330, Mexico|Investigación Nefrológica, Cuernavaca, Morelos, 62448, Mexico|Centro de Investigación y Gastroenterología, Cuauhtémoc, 06700, Mexico|Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, 14080, Mexico|Amsterdam UMC, locatie VUmc, Amsterdam, Noord-Holland, 1081 HV, Netherlands|Ziekenhuisgroep Twente, locatie Almelo, Almelo, Overijssel, 7609 PP, Netherlands
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