| Outcome Measures: |
Primary: Change in the glomerular filtration rate, It will be measure as to duplicate serum creatinine levels from baseline (mg/dL), or to pass from a stage of chronic kidney disease to he next stage (GFR mL/min), The measurements will be done baseline and every six months up to 24 months. | Secondary: Change in oxidative stress marker., The change in vit C level from baseline (normal range 4-8.8mg/ L), Change is assessed baseline, 6 months, 12 months, 18 months and 24 months.|Change in fibrosis markers., Change in Nt_ProBNP from the baseline (Normal values up to 381 pg/mL), Change is assessed baseline, 6 months, 12 months, 18 months and 24 months.|Change in inflammation markers., To assess inflammation high sensitivity C reactive protein will be measured by nephelometry. (normal value \< 5 mg/L, Change is assessed baseline, 6 months, 12 months, 18 months and 24 months.|Change in health-related quality of life, This outcome will be measured by the SF 36 questionnaire, themaximun punctuation is 100, as greater punctuation a better quality of life, The questionnaire will be applied baseline and every six months up to 24 months.
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