CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Clinical Trial Details

Trial ID:	L1394
Source ID:	NCT00240331
Associated Drug:	10mg Rosuvastatin
Title:	AURORA: Crestor 10mg Versus Placebo in Subjects With End-stage Renal Disease (ESRD)
Acronym:
Status:	COMPLETED
Study Results:	YES
Results:	https://ClinicalTrials.gov/show/NCT00240331/results
Conditions:	Renal Failure
Interventions:	DRUG: 10mg Rosuvastatin\|DRUG: Placebo
Outcome Measures:	Primary: Number of Randomised Participants With a Major Cardiovascular Event (Non-fatal Stroke, Non-fatal Myocardial Infarction or Cardiovascular Death), Events were reported continuously during the study. Duration of follow-up ranged from 1 day to 5.6 years \| Secondary: Number of Randomised Participants That Died From Any Cause., Events were reported continuously during the study. Duration of follow-up ranged from 1 day to 5.6 years\|Number of Randomised Participants With a Major Cardiovascular Event or That Died From Any Known Cause, Events were reported continuously during the study. Duration of follow-up ranged from 1 day to 5.6 years\|Number of Randomised Participants That Died From Cardiovascular Cause, Events were reported continuously during the study. Duration of follow-up ranged from 1 day to 5.6 years\|Number of Randomised Participants That Died From Non Cardiovascular Cause, Events were reported continuously during the study. Duration of follow-up ranged from 1 day to 5.6 years\|Number of Randomised Participants With an Atherosclerotic Cardiac Event (Non-fatal Myocardial Infarction or Coronary Heart Disease (CHD) Death), Events were reported continuously during the study. Duration of follow-up ranged from 1 day to 5.6 years\|Number of Randomised Participants That Experienced a Procedure as a Result of Stenosis or Thrombosis of the Vascular Access (Arteriovenous (AV) Fistulas and Grafts Only) for Haemodialysis., Events were reported continuously during the study. Duration of follow-up ranged from 1 day to 5.6 years\|Number of Randomised Participants That Experienced a Coronary or Peripheral Revascularisation (Including Above Ankle Limb Amputations)., Events were reported continuously during the study. Duration of follow-up ranged from 1 day to 5.6 years
Sponsor/Collaborators:	Sponsor: AstraZeneca
Gender:	ALL
Age:	ADULT, OLDER_ADULT
Phases:	PHASE3
Enrollment:	2776
Study Type:	INTERVENTIONAL
Study Designs:	Allocation: RANDOMIZED\|Intervention Model: PARALLEL\|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)\|Primary Purpose: PREVENTION
Start Date:	2003-01
Completion Date:	2008-10
Results First Posted:	2009-11-04
Last Update Posted:	2011-05-19
Locations:	Research Site, St Leonards, New South Wales, Australia\|Research Site, Herston, Queensland, Australia\|Research Site, Bregenz, Austria\|Research Site, Feldkirch-Tisis, Austria\|Research Site, Graz, Austria\|Research Site, Innsbruck, Austria\|Research Site, Linz, Austria\|Research Site, St. Poelten, Austria\|Research Site, Wels, Austria\|Research Site, Wien, Austria\|Research Site, Aalst, Belgium\|Research Site, Antwerpen, Belgium\|Research Site, Brussels, Belgium\|Research Site, La Louviere, Belgium\|Research Site, Leuven, Belgium\|Research Site, Liège, Belgium\|Research Site, Curitiba, PR, Brazil\|Research Site, Sao Paulo, SP, Brazil\|Research Site, Pleven, Bulgaria\|Research Site, Plovdiv, Bulgaria\|Research Site, Sofia, Bulgaria\|Research Site, Calgary, Alberta, Canada\|Research Site, Edmonton, Alberta, Canada\|Research Site, Lethbridge, Alberta, Canada\|Research Site, Kelowna, British Columbia, Canada\|Research Site, Vancouver, British Columbia, Canada\|Research Site, Winnipeg, Manitoba, Canada\|Research Site, Saint John, New Brunswick, Canada\|Research Site, Halifax, Nova Scotia, Canada\|Research Site, London, Ontario, Canada\|Research Site, Mississauga, Ontario, Canada\|Research Site, Scarborough, Ontario, Canada\|Research Site, Toronto, Ontario, Canada\|Research Site, York, Ontario, Canada\|Research Site, Greenfield Park, Quebec, Canada\|Research Site, Laval, Quebec, Canada\|Research Site, Montreal, Quebec, Canada\|Research Site, Trois-Rivieres, Quebec, Canada\|Research Site, Kitchener, Canada\|Research Site, Rosemount, Canada\|Research Site, Hodonin, Czech Republic\|Research Site, Hradec Kralove, Czech Republic\|Research Site, Liberec, Czech Republic\|Research Site, Pardubice, Czech Republic\|Research Site, Praha 2, Czech Republic\|Research Site, Praha 4, Czech Republic\|Research Site, Praha 6, Czech Republic\|Research Site, Tabor, Czech Republic\|Research Site, Usti nad Labem, Czech Republic\|Research Site, Fredericia, Denmark\|Research Site, Frederiksberg, Denmark\|Research Site, Herlev, Denmark\|Research Site, Holbaek, Denmark\|Research Site, Horsens, Denmark\|Research Site, København Ø, Denmark\|Research Site, Roskilde, Denmark\|Research Site, Rønne, Denmark\|Research Site, Slagelse, Denmark\|Research Site, Sønderborg, Denmark\|Research Site, Viborg, Denmark\|Research Site, Helsinki, Finland\|Research Site, Hyvinkaa, Finland\|Research Site, Joensuu, Finland\|Research Site, Kotka, Finland\|Research Site, Kuopio, Finland\|Research Site, Lahti, Finland\|Research Site, Oulu, Finland\|Research Site, Pori, Finland\|Research Site, Tammisaari, Finland\|Research Site, Tampere, Finland\|Research Site, Turku, Finland\|Research Site, Amiens, France\|Research Site, Annonay Cedex, France\|Research Site, Aubervilliers, France\|Research Site, Beauvais, France\|Research Site, Bethune Cedex, France\|Research Site, Boulogne Sur Mer, France\|Research Site, Chambery, France\|Research Site, Champigny Sur Marne, France\|Research Site, Colmar Cedex, France\|Research Site, Creil Cedex 1, France\|Research Site, Evreux Cedex, France\|Research Site, Fleury Merogis, France\|Research Site, Foix Cedex, France\|Research Site, Le Kremlin-Bicetre, France\|Research Site, Maubeuge, France\|Research Site, Meaux, France\|Research Site, Mont de Marsan Cedex, France\|Research Site, Montbonnot Saint Martin, France\|Research Site, Nimes, France\|Research Site, Olivet, France\|Research Site, Paris, France\|Research Site, Quimper Cedex, France\|Research Site, Saint Maurice, France\|Research Site, Saint Michel, France\|Research Site, Tournan En Brie, France\|Research Site, Valenciennes Cedex, France\|Research Site, Vandoeuvre Les Nancy, France\|Research Site, Vichy, France\|Research Site, Ansbach, Germany\|Research Site, Aschaffenburg, Germany\|Research Site, Bad Münder, Germany\|Research Site, Berlin, Germany\|Research Site, Bischofswerda, Germany\|Research Site, Dresden, Germany\|Research Site, Duisburg, Germany\|Research Site, Düsseldorf, Germany\|Research Site, Erlangen, Germany\|Research Site, Frankfurt, Germany\|Research Site, Freiburg, Germany\|Research Site, Greifswald, Germany\|Research Site, Hann Münden, Germany\|Research Site, Ingolstadt, Germany\|Research Site, Jena, Germany\|Research Site, Kaufbeuren, Germany\|Research Site, Luedenscheid, Germany\|Research Site, Marktheidenfeld, Germany\|Research Site, München, Germany\|Research Site, Pfarrkirchen, Germany\|Research Site, Pirmasens, Germany\|Research Site, Regensburg, Germany\|Research Site, Rostock, Germany\|Research Site, Saarbrucken, Germany\|Research Site, Tangermünde, Germany\|Research Site, Waldshut, Germany\|Research Site, Alexandroupoli, Greece\|Research Site, Athens, Greece\|Research Site, Ioannina, Greece\|Research Site, Thessaloniki, Greece\|Research Site, Veroia, Greece\|Research Site, Budapest, Hungary\|Research Site, Gyor, Hungary\|Research Site, Miskolc, Hungary\|Research Site, Nyiregyhaza, Hungary\|Research Site, Szeged, Hungary\|Research Site, Székesfehérvár, Hungary\|Research Site, Veszprém, Hungary\|Research Site, Reykjavik, Iceland\|Research Site, Galway, Ireland\|Research Site, Bergamo, BG, Italy\|Research Site, Treviglio, BG, Italy\|Research Site, Cremona, CR, Italy\|Research Site, Genova, GE, Italy\|Research Site, Lodi, LO, Italy\|Research Site, Milano, Mi, Italy\|Research Site, Rozzano, MI, Italy\|Research Site, Reggio Calabria, RC, Italy\|Research Site, Busto Arsizio, VA, Italy\|Research Site, Seongnam-Si, Korea, Korea, Republic of\|Research Site, Seoul, Korea, Korea, Republic of\|Research Site, Mexico, D.f., Mexico\|Research Site, Acapulco, Guerrero, Mexico\|Research Site, Guadalajara, Jalisco, Mexico\|Research Site, Cuernavaca, Morelos, Mexico\|Research Site, Monterrey, Nuevo Leon, Mexico\|Research Site, Distrito Federal, Mexico\|Research Site, San Luis Potosi, Mexico\|Research Site, Alkmaar, Netherlands\|Research Site, Almelo, Netherlands\|Research Site, Amersfoort, Netherlands\|Research Site, Amsterdam, Netherlands\|Research Site, Arnhem, Netherlands\|Research Site, Den Bosch, Netherlands\|Research Site, Den Haag, Netherlands\|Research Site, Deventer, Netherlands\|Research Site, Dordrecht, Netherlands\|Research Site, Emmen, Netherlands\|Research Site, Groningen, Netherlands\|Research Site, Leeuwarden, Netherlands\|Research Site, Nieuwegein, Netherlands\|Research Site, Rotterdam, Netherlands\|Research Site, Sittard, Netherlands\|Research Site, Tilburg, Netherlands\|Research Site, Bergen, Norway\|Research Site, Drammen, Norway\|Research Site, Fredrikstad, Norway\|Research Site, Lillehammer, Norway\|Research Site, Lorenskog, Norway\|Research Site, Oslo, Norway\|Research Site, Skien, Norway\|Research Site, Stavanger, Norway\|Research Site, Trondheim, Norway\|Research Site, Tønsberg, Norway\|Research Site, Bialystok, Poland\|Research Site, Gdansk, Poland\|Research Site, Katowice, Poland\|Research Site, Kraków, Poland\|Research Site, Lublin, Poland\|Research Site, Opole, Poland\|Research Site, Plock, Poland\|Research Site, Rybnik, Poland\|Research Site, Wloclawek, Poland\|Research Site, Eksjö, Sweden\|Research Site, Eskilstuna, Sweden\|Research Site, Falun, Sweden\|Research Site, Gävle, Sweden\|Research Site, Göteborg, Sweden\|Research Site, Jönköping, Sweden\|Research Site, Karlstad, Sweden\|Research Site, Linköping, Sweden\|Research Site, Lund, Sweden\|Research Site, Mölndal, Sweden\|Research Site, Norrköping, Sweden\|Research Site, Skövde, Sweden\|Research Site, Stockholm, Sweden\|Research Site, Trollhättan, Sweden\|Research Site, Uppsala, Sweden\|Research Site, Örebro, Sweden\|Research Site, Aarau, Switzerland\|Research Site, Bern, Switzerland\|Research Site, Geneve, Switzerland\|Research Site, Lausanne, Switzerland\|Research Site, St. Gallen, Switzerland\|Research Site, Zürich, Switzerland\|Research Site, Istanbul, Altunizade, Turkey\|Research Site, Cebeci, Ankara, Turkey\|Research Site, Kampus, Antalya, Turkey\|Research Site, Antalya, Arapsuyu, Turkey\|Research Site, Ankara, Besevler, Turkey\|Research Site, Izmir, Bornova, Turkey\|Research Site, Bursa, Gorukle, Turkey\|Research Site, Istanbul, Haydarpasa, Turkey\|Research Site, Antrim, Northern Ireland, United Kingdom\|Research Site, Belfast, Northern Ireland, United Kingdom\|Research Site, Newry, Northern Ireland, United Kingdom\|Research Site, Omagh, Northern Ireland, United Kingdom\|Research Site, Bradford, United Kingdom\|Research Site, Dumfries, United Kingdom\|Research Site, Dundee, United Kingdom\|Research Site, Glasgow, United Kingdom\|Research Site, Hull, United Kingdom\|Research Site, Kilmarnock, United Kingdom\|Research Site, Leeds, United Kingdom\|Research Site, London, United Kingdom\|Research Site, Manchester, United Kingdom\|Research Site, Middlesborough, United Kingdom\|Research Site, Newcastle, United Kingdom\|Research Site, Plymouth, United Kingdom\|Research Site, Rhyl, United Kingdom\|Research Site, Sheffield, United Kingdom\|Research Site, Surrey, United Kingdom
URL:	https://clinicaltrials.gov/show/NCT00240331

Knowledge Graph
Associated Data

Drug ID	Drug Name	Type	DrugBank ID	Targets	Category	Latest Progress

Clinical Trial Details

Summary

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Associated Data

Associated NAFLD Drugs (0)