| Outcome Measures: |
Primary: Serum T50 for CPP, The maturation time (T50) of calciprotein particles in serum will be measured. T50 CPP (measured by Calcisco using Pasch's method) assays the kinetics of transformation from primary to secondary CPP in vitro. Fresh serum samples will be kept at -80 degrees until shipment to Calcisco AG (Berne, Switzerland) for T50 analysis, which will determine T50 of CPP through research collaboration with CMMCR., 24 months | Secondary: Intracellular muscle magnesium, Intracellular Mg will be measured in calf muscle, by using 31P magnetic resonance spectroscopy, based on the formula: \[Mg\] - kd(10.796-D)/(D-8.251), in which kd is the dissociation constant for MgATP complex (=50 µM) and D is the chemical shift difference between alpha- and beta-ATP 31P signals observed in 31P MR spectrum., 24 months|Control of hyperphosphatemia and serum FGF23, The control of hyperphosphatemia will be evaluated from changes in serum P concentration, serum FGF23 and Klotho., 24 months|Parathyroid function and bone turnover, Parathyroid function will be evaluated from serum PTH, vitamin D status from serum calcitriol, bone resorption from serum CTX, and bone formation from serum BSAP. Change in bone mass will be evaluated by BMD (proximal femur, L2-L4 spine and distal third of radius)., 24 months
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