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Clinical Trial Details

Trial ID: L1545
Source ID: NCT05485961
Associated Drug: Csl300
Title: Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis
Acronym: POSIBIL6ESKD
Status: RECRUITING
Study Results: NO
Results:
Conditions: Atherosclerotic Cardiovascular Disease|End Stage Kidney Disease|Atherosclerotic Cardiovascular Disease in Patients With ESKD
Interventions: DRUG: CSL300|DRUG: Placebo|DRUG: Placebo
Outcome Measures: Primary: Change from Baseline on the log scale in high-sensitivity C-reactive protein (hs-CRP)(Phase 2b), Baseline and up to 12 weeks|Time to first occurrence of CV death or myocardial infarction (MI) (Phase 3), Approximately 5 years | Secondary: Percent of participants achieving hs-CRP less than (<) 2.0 milligram per Liter (mg/L) (Phase 2b), Week 12|Change from baseline in log-transformed hs-CRP (Phase 2b), Baseline and up to 24 weeks|Mean change from Baseline in serum amyloid A (SAA) (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in secretory phospholipase A2 (sPLA2) (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in fibrinogen (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in plasminogen activator inhibitor -1 (PAI-1) (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in lipoprotein (Lp) (a) (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in albumin (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in Hepcidin (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in hemoglobin (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in erythropoiesis-stimulating agents (ESA) (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in erythropoietin-resistance index (ERI) (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in iron (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in total iron binding capacity (TIBC) (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in transferrin saturation (TSAT) (Phase 2b), Baseline and up to 12 weeks|Mean change from Baseline in ferritin (Phase 2b), Baseline and up to 12 weeks|Area under the plasma concentration versus time curve (AUC) for CSL300 (Phase 2b), Up to 24 weeks|Peak Plasma Concentration (Cmax) for CSL300 (Phase 2b), Up to 24 weeks|Trough Plasma Concentration (Ctrough) for CSL300 (Phase 2b), Up to 24 weeks|Time to Maximum Plasma Concentration (Tmax) for CSL300 (Phase 2b), Up to 24 weeks|Percent of participants with adverse events (AE), serious AE (SAE), including adverse events of special interest (AESIs) (Phase 2b), Up to 32 weeks|Mean change from Baseline in white blood cell (WBC) (Phase 2b), Up to 12 weeks|Mean change from Baseline in neutrophils (Phase 2b), Up to 12 weeks|Mean change from Baseline in platelets (Phase 2b), Up to 12 weeks|Mean change from Baseline in aspartate aminotransferase (AST) (Phase 2b), Up to 12 weeks|Mean change from Baseline in alanine aminotransferase (ALT) (Phase 2b), Up to 12 weeks|Mean change from Baseline in total bilirubin (Phase 2b), Up to 12 weeks|Mean change from Baseline in lipid panel (Phase 2b), Lipid panel consists of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride., Up to 12 weeks|Titer of confirmed antibodies specific to CSL300 (Phase 2b), Up to 12 weeks|Time to first occurrence of all-cause death or MI (Phase 3), Approximately 5 years|Time to first occurrence of CV death, MI, or ischemic stroke (Phase 3), Approximately 5 years|Time to first occurrence of CV death (Phase 3), Approximately 5 years|Time to first occurrence of CV death, MI or major adverse limb event (Phase 3), Approximately 5 years|Time to first occurrence of all-cause death (Phase 3), Approximately 5 years|Time to first occurrence of CV death, MI, or hospitalization for heart failure (HF) (Phase 3), Approximately 5 years|Total number of CV hospitalizations (Phase 3), Approximately 5 years|Total number of HF hospitalizations and urgent visits (Phase 3), Approximately 5 years|Total number of hospitalizations (Phase 3), Approximately 5 years
Sponsor/Collaborators: Sponsor: CSL Behring
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE2|PHASE3
Enrollment: 2310
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Start Date: 2022-10-21
Completion Date: 2029-08-30
Results First Posted:
Last Update Posted: 2025-04-08
Locations: 84000149 - Nephrology Consultants, LLC, Huntsville, Alabama, 35805, United States|84000340 - DaVita Clinical Research Montgomery, Montgomery, Alabama, 36117, United States|84000552 - AKDHC Medical, Glendale, Arizona, 85305, United States|84000178 - Kidney Disease Medical Group, Glendale, Arizona, 91206, United States|84000231 - AKDHC Medical, Phoenix, Arizona, 85018, United States|84000286 - AKDHC Medical, Tucson, Arizona, 85705, United States|84000145 - National Institute of Clinical Research, Bakersfield, California, 93309, United States|84000151 - National Institute of Clinical Research, Bakersfield, California, 93309, United States|84000277 - Amicis Research Center, Beverly Hills, California, 90211, United States|84000241 - California Institute of Renal Research, Chula Vista, California, 91910, United States|84000462 - Davita Fullerton Dialysis Center, Fullerton, California, 92832, United States|84000574 - National Institute of Clinical Research, Inc., Fullerton, California, 92835, United States|84000464 - St. Jude Medical Center, Garden Grove, California, 92843, United States|84000573 - National Institute of Clinical Research, Inc., Garden Grove, California, 92843, United States|84000152 - National Institute of Clinical Research, Garden Grove, California, 92844, United States|84000531 - Sherman Medical Group, Inc, Glendale, California, 91204, United States|84000230 - Kidney Disease Medical Group, Glendale, California, 91206, United States|84000379 - Renal Consultants Medical Group, Granada Hills, California, 91344, United States|84000221 - California Institute of Renal Research, La Mesa, California, 91942, United States|84000235 - California Institute of Renal Research, La Mesa, California, 91942, United States|84000198 - Southern California Medical Research Center, La Palma, California, 90623, United States|84000467 - Southern California Medical Research Center, La Palma, California, 90623, United States|84000329 - Academic Medical Research Institute, Los Angeles, California, 90022, United States|84000439 - National Institute of Clinical Research, Inc., Los Angeles, California, 90027, United States|84000158 - DaVita Carabello Dialysis Center, Los Angeles, California, 90033, United States|84000175 - Renal Medical Associates/NARI, Lynwood, California, 90262, United States|84000279 - Amicis Research Center, Northridge, California, 91324, United States|84000533 - FORMAT Medical Research, Oxnard, California, 93036, United States|84000331 - Van Buren Dialysis Center, Riverside, California, 92504, United States|84000228 - National Nephrology Alliance Research - Riverside, Riverside, California, 92505, United States|84000492 - Central Coast Nephrology Medical Corp, Salinas, California, 93901, United States|84000238 - California Institute of Renal Research, San Diego, California, 92111, United States|84000143 - California Institute of Renal Research, San Diego, California, 92123, United States|84000330 - North America Research Institute, San Dimas, California, 91773, United States|84000341 - North America Research Institute, San Dimas, California, 91773, United States|84000281 - Satellite Healthcare, San Jose, California, 95126, United States|84000440 - Nephrology Educational Services, Tarzana, California, 91356, United States|84000278 - Amicis Research Center, Vacaville, California, 95687, United States|84000323 - National Institute of Clinical Research, Inc, Victorville, California, 92392, United States|84000174 - DaVita Vista Del Sol Dialysis, Victorville, California, 92394, United States|84000454 - Kidney Associates of Colorado, P.C., Denver, Colorado, 80210, United States|84000223 - Colorado Kidney Care, Denver, Colorado, 80230, United States|84000176 - Greater Hartford Nephrology, LLC, Bloomfield, Connecticut, 06002, United States|84000173 - Nephrology and Hypertension Associates PC, Middlebury, Connecticut, 06762, United States|84000494 - Nephrology Associates (Delaware), Newark, Delaware, 19713, United States|84000441 - Boca Raton Regional - Research Physicians Network Alliance, Boca Raton, Florida, 33431, United States|84000193 - Horizon Research Group LLC, Coral Gables, Florida, 33134, United States|84000443 - South Florida Nephrology Group, PA, Coral Springs, Florida, 33071, United States|84000597 - Family First Medical Research Center, Hialeah Gardens, Florida, 33016, United States|84000406 - Elixia Pines, Hollywood, Florida, 33024, United States|84000140 -South Florida Research Institute, Lauderdale Lakes, Florida, 33313, United States|84000599 - South Florida Research Organization LLC, Medley, Florida, 33166, United States|84000527 - Floridian Clinical Research, Miami Lakes, Florida, 33016, United States|84000495 - Total Research Group, LLC, Miami, Florida, 33126, United States|84000362 - Kidney and Hypertension Specialists of Miami, Miami, Florida, 33150, United States|84000182 - Nephrology Associates of South Miami, Miami, Florida, 33173, United States|84000400 - Elixia Central Florida, Orlando, Florida, 32806, United States|84000139 - Genesis Clinical Research, Tampa, Florida, 33603, United States|84000532 - Florida Kidney Specialists, Temple Terrace, Florida, 33637, United States|84000426 - Florida Premier Research Institute, Winter Park, Florida, 32789, United States|84000326 - Coastal Medical Research, LLC, Brunswick, Georgia, 31520, United States|84000157 - Renal Associates LLC, Columbus, Georgia, 31904, United States|84000327 - American Clinical Trials, Douglasville, Georgia, 30101, United States|84000194 - Atekha Nephrology Clinic LLC, Statesboro, Georgia, 30458, United States|84000453 - Nephrology Physician's LLC, Mishawaka, Indiana, 46545, United States|84000534 - Dunes Clinical Research LLC, Sioux City, Iowa, 57049, United States|84000374 - Kansas Nephrology Physicians, PA, Wichita, Kansas, 67214, United States|84000554 - Nephrology Associates of Kentuckiana, PSC, Louisville, Kentucky, 40205, United States|84000550 - Renal Associates of Baton Rouge, Baton Rouge, Louisiana, 70808, United States|84000465 - Paragon Health, Inc, Kalamazoo, Michigan, 49007, United States|84000408 - Michigan Kidney Consultants, PC, Pontiac, Michigan, 48341, United States|84000171 - St. Clair Nephrology Research, Roseville, Michigan, 48066, United States|84000237 - Center for Advanced Kidney Research, PLC, Saint Clair Shores, Michigan, 48081, United States|84000146 - DCR Edina, Minneapolis, Minnesota, 55404, United States|84000338 - DCR Edina, Minneapolis, Minnesota, 55404, United States|84000225 - Southwest Mississippi Nephrology PLLC, Brookhaven, Mississippi, 39601, United States|84000153 - Nephrology Associates, PC, Columbus, Mississippi, 39705, United States|84000144 - Nephrology and Hypertension Associates Ltd, Tupelo, Mississippi, 38801, United States|84000147 - Clinical Research Consultants, Kansas City, Missouri, 64111, United States|84000328 - GSR Enterprises, Inc., Lincoln, Nebraska, 68510, United States|84000222 - Great Plains Health - Nephrology, North Platte, Nebraska, 69101, United States|84000420 - DaVita Clinical Research - Henderson, Henderson, Nevada, 89074, United States|84000337 - Kidney Specialists of Southern Nevada, Las Vegas, Nevada, 89106, United States|84000148 - Sierra Nevada Specialty Care, Reno, Nevada, 89511, United States|84000141 - Seacoast Kidney and Hypertension Specialists, Portsmouth, New Hampshire, 03801, United States|84000436 - Hypertension & Nephrology Association, Eatontown, New Jersey, 07724, United States|84000452 - New Jersey Kidney Care, Jersey City, New Jersey, 07305, United States|84000155 - DaVita Clinic Research Bronx, Bronx, New York, 10461, United States|84000276 - Albert Einstein College of Medicine - Montefiore Medical Center, Bronx, New York, 10467, United States|84000184 - Mattoo & Bhat Medical Associates, P.C., College Point, New York, 11356, United States|84000191 - Metrolina Nephrology Associates, PA, Charlotte, North Carolina, 28204, United States|84000150 - Durham Nephrology Associates, PA, Durham, North Carolina, 27704, United States|84000232 - East Carolina University, Greenville, North Carolina, 27858, United States|84000410 - North Carolina Nephrology, PA, Raleigh, North Carolina, 27610, United States|84000548 - HNC Dialysis, Ltd., Columbus, Ohio, 43215, United States|84000234 - Northeast Clinical Research Center, LLC, Bethlehem, Pennsylvania, 18017, United States|84000192 - Columbia Nephrology, Columbia, South Carolina, 29203, United States|84000229 - DaVita Clinical Research, Spartanburg, South Carolina, 29306, United States|84000180 - Knoxville Kidney Center PLLC, Knoxville, Tennessee, 37923, United States|84000451 - Cussimanio Research Group LLC, Austin, Texas, 78751, United States|84000438 - Research Management, Inc., Austin, Texas, 78758, United States|84000549 - MW Clinical Research Center, Beaumont, Texas, 77701, United States|84000457 - US Renal Care, Dallas, Texas, 75237, United States|84000354 - Davita Clinical Research, El Paso, Texas, 79925, United States|84000421 - DaVita Clinical Research - Horizon, El Paso, Texas, 79935, United States|84000458 - Fort Worth Renal Group, Fort Worth, Texas, 76110, United States|84000350 - DaVita Clinical Research, Houston, Texas, 77054, United States|84000498 - DaVita Clinical Research, Houston, Texas, 77054, United States|84000598 - Aqua Research Institute, Houston, Texas, 77058, United States|84000450 - Houston Medical Research Institute, LLC, Houston, Texas, 77074, United States|84000360 - Clinical Research Strategies, Inc., Houston, Texas, 77090, United States|84000196 - Southwest Houston Research, Houston, Texas, 77099, United States|84000373 - Gamma Medical Research, Inc., McAllen, Texas, 78503, United States|84000324 - National Institute of Clinical Research, Inc., San Antonio, Texas, 78204, United States|84000351 - DaVita Clinical Research, San Antonio, Texas, 78229, United States|84000419 - Davita Clinical Research, San Antonio, Texas, 78251, United States|84000553 - DCR-San Antonio Stone Oak, San Antonio, Texas, 78258, United States|84000339 - DaVita Clinical Research North Houston, Shenandoah, Texas, 77384, United States|84000535 - DCR-Norfolk Great Bridge, Chesapeake, Virginia, 23320, United States|84000424 - Nephrology Associates of Northern Virginia Inc, Fairfax, Virginia, 22033, United States|84000138 - Peninsula Kidney Associates, Hampton, Virginia, 23666, United States|84000156 - Tidewater Kidney Specialists, Norfolk, Virginia, 23502, United States|84000336 - Nephrology and Hypertension Associates, Bluefield, West Virginia, 24701, United States|03600023 - Royal North Shore Hospital (RNSH), Saint Leonards, New South Wales, 2065, Australia|03600017 - Concord Repatriation General Hospital, Sydney, New South Wales, 2139, Australia|03600037 - Cairns Hospital, Cairns, Queensland, 4870, Australia|03600021 - Sunshine Coast University Private Hospital, Nambour, Queensland, 4560, Australia|03600014 - Princess Alexandra Hospital, Woolloongabba, Queensland, 4102, Australia|03600013 - Monash Medical Centre, Clayton, Victoria, 3168, Australia|03600011 - Sunshine Hospital, St Albans, Victoria, 3021, Australia|03600011 - Sunshine Hospital, St Albans, Victoria, 3021, Australia|03600050 - Fiona Stanley Hospital, Murdoch, 6150, Australia|03600021 - Sunshine Coast University Private Hospital, Nambour, 4560, Australia|03600020 - Gold Coast University Hospital, Southport, 4215, Australia|03600012 - Westmead Hospital, Westmead, 2145, Australia|03600048 - Wollongong Renal Unit, Wollongong, 2500, Australia|05600011 - Onze-Lieve-Vrouwziekenhuis VZW, Aalst, 9300, Belgium|05600011 - Onze-Lieve-Vrouwziekenhuis VZW, Aalst, 9300, Belgium|05600005 - Imelda Ziekenhuis, Bonheiden, 2820, Belgium|05600004 - AZ Sint-Lucas, Gent, 9000, Belgium|05600012 - Universitair Ziekenhuis Leuven, Leuven, 3000, Belgium|05600003 - CHR de la Citadelle, Liège, 4000, Belgium|05600003 - CHR de la Citadelle, Liège, 4000, Belgium|05600018 - AZ Delta (H.-Hartziekenhuis Roeselare-Menen vzw (HHRM)) - Campus Rumbeke, Roeselare, 8800, Belgium|10000002 - Multiprofile Hospital for Active Treatment- Sveti Nikolay Chudotvoretz - LOM EOOD, Lom, 3600, Bulgaria|10000001 - Medical Center - Smolyan OOD, Smolyan, 4700, Bulgaria|10000005 - Dialysis Center VIA DIAL OOD, Stara Zagora, 6000, Bulgaria|12400008 - University of Alberta Hospital, Edmonton, Alberta, T6G2P4, Canada|12400021 - Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, B3H 3A6, Canada|12400026 - St. Josephs Healthcare Hamilton, Hamilton, Ontario, L8N 4A6, Canada|12400009 - Kingston Health Sciences Centre, Kingston, Ontario, K7L 2V7, Canada|12400030 - London Health Sciences Centre - University Hospital, London, Ontario, N6A 5A5, Canada|12400024 - Lakeridge Health Oshawa, Oshawa, Ontario, L1G 2B9, Canada|12400023 - McGill University Health Centre, Montreal, Quebec, H4A 3J1, Canada|12400032 - St. Michaels Hospital, Toronto, M5B 1W8, Canada|20800009 - Aalborg Universitetshospital, Aalborg, 9000, Denmark|20800010 - Herlev Hospital, Herlev, 2730, Denmark|20800008 - Gødstrup Hospital, Herning, 7400, Denmark|20800011 - Trail Nation: Nordsjællands Hospital, Hillerød, 3400, Denmark|25000011 - CHU Amiens - Nephrology Dialysi Transplantation Department, Amiens, 80054, France|25000027 - Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital de la Cavale Blanche, Brest, 29200, France|25000013 - CHU de Caen, Caen, 14000, France|25000025 - AURA Paris - Plaisance, Paris, 75014, France|25000016 - AURA St Quen Dialysis centre, Saint-Ouen, 93400, France|25000029 - Hôpitaux Universitaires de Strasbourg - Hôpital Civil, Strasbourg, 67091, France|25000012 - CHU Rangueil, Toulouse, 31059, France|27600047 - Charite-Universitatsmedizin Berlin, Berlin, 13353, Germany|27600041 - Nierenzentrum Bad König, Hessen, 64732, Germany|27600039 - Westpfalz Klinikum GmbH, Kaiserslautern, 67655, Germany|27600022 - UKSH - Universitatsklinik Schleswig-Holstein, Kiel, 24105, Germany|27600040 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, 55131, Germany|27600020 - Nephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen, 78052, Germany|27600020 - Nephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen, 78052, Germany|30000012 - University General Hospital of Heraklion, Crete, 71500, Greece|30000004 - University General Hospital of Ioannina, Ioánnina, 45110, Greece|30000002 - General Hospital of Ioannina G. Hatzikosta, Ioánnina, 45445, Greece|30000014 - Nephrological Clinic University Hospital, University of Thessaly, Larissa, 41110, Greece|30000008 - University Hospital of Patras, Rio, 265 04, Greece|30000005 - Aristotle University, Hippokration, Thessaloniki, 54642, Greece|30000003 - AHEPA Univ. Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloníki, 45500, Greece|30000006 - General Hospital of Thessaloniki, Agios Pavlos, Thessaloníki, 55134, Greece|30000009 - Papageorgiou General Hospital of Thessaloniki, Thessaloníki, 56403, Greece|30000011 - Nephrology Department G. Papanikolaou General Hospital, Thessaloníki, 570 10, Greece|30000016 - General Hospital of Arta, Árta, 471 00, Greece|34800012 - B. Braun Avitum - 14. Dialízisközpont Kistarcs, Kistarcsa, 2143, Hungary|37600008 - Carmel Medical Center, Haifa, 3436212, Israel|37600012 - Edith Wolfson Medical Center, H̱olon, 58100, Israel|37600010 - Rabin Medical Center, Petah Tikva, 4941492, Israel|37600011 - Chaim Sheba Medical Center (Sheba Tel-Hashomer Medical Center ), Ramat Gan, 3109601, Israel|37600009 - Ichilov Hospital-Tel-Aviv Sourasky Medical Center, Tel Aviv, 84100, Israel|37600002 - Medical Research & Development Fund for Health Services, PORIYA Hospital, Tiberias, 15208, Israel|37600013 - Ziv Medical Center, Zefat, 13110, Israel|38000025 - ASST degli Spedali Civili di Brescia, Brescia, 25123, Italy|38000031 - Azienda Ospedaliera Sant'Anna e San Sebastiano di Caserta, Caserta, 81100, Italy|38000074 - Ospedale Santa Maria Annunziata, Florence, 50012, Italy|38000027 - A. O. -Universitaria Ospedali Riuniti di Foggia Farmacia Osp, Foggia, 71122, Italy|38000029 - Università degli Studi di Messina, Messina, 98124, Italy|38000023 - IRCCS Ospedale San Raffaele, Milano, 20132, Italy|38000019 - ICS Maugeri S.p.A. SB; Università di Pavia; Fondazione Salvatore Maugeri IRCCS, Pavia, 2700, Italy|38000026 - University of Verona, Peschiera Del Garda, 37019, Italy|38000032 - Ospedale Santo Stefan, Prato, 59100, Italy|38000067 - Rimini Hospital, Rimini, 47923, Italy|38000016 - Ospedale Casa Sollievo della Sofferenza (CSS), San Giovanni Rotondo, 71013, Italy|38000020 - Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona, 37126, Italy|39200053 - Daiyukai Daiichi Hospital, Ichinomiya-shi, Aichi, 491-8551, Japan|39200044 - Juntendo University Urayasu Hospital, Urayasu-shi, Chiba-ken, 279-0021, Japan|39200046 - Steel Memorial Yawata Hospital, Kitakyushu-shi, Fukuoka, 805-0050, Japan|39200048 - Maebashi Hirosegawa Clinic, Maebashi-shi, Gunma, 371-0022, Japan|39200049 - Joumou Ohashi Clinic, Maebashi-shi, Gunma, 371-0046, Japan|39200045 - Teine Urological Clinic, Sapporo-shi, Hokkaido, 006-0816, Japan|39200054 - Omi freai Hospital, Kusatsu-shi, Shiga, 525-8585, Japan|39200027 - Tokyo Womens Med University, Shinjuku-Ku, Tokyo, 162-8666, Japan|39200042 - Matsunami General Hospital, Hashima-gun, 501-6062, Japan|39200041 - Ishikiriseiki Hospital, Higashiosaka-shi, 579-8026, Japan|39200055 - Miki Internal Medicine Urology Clinic, Hokkaido, 041-1121, Japan|39200033 - Tokyo Medical University Ibaraki Medical Center, Inashiki-gun, 300-0332, Japan|39200043 - Ueyama Hospital, Kagoshima-shi, 890-0073, Japan|39200038 - St. Mary's Hospital, Kurume-shi, 830-8543, Japan|39200021 - Kurume University Hospital, Kurume, 830-0011, Japan|39200028 - Rakuwakai Otowa Kinen Hospital, Kyoto-Shi, 607-8116, Japan|39200037 - Nagaoka Red-Cross Hospital, Nagaoka-Shi, 940-2085, Japan|39200035 - Daido Hospital, Nagoya-shi, 457-8511, Japan|39200020 - Chubu Rosai Hospital, Nagoya, 455-8530, Japan|39200026 - Omihachiman Community Medical Center - Kidney Center, Omihachiman, 523-0082, Japan|39200032 - Oguranaika Jin Cinic, Oyama-shi, 323-0831, Japan|39200029 - Ibaraki Seinan Medical Center Hospital, Sakaimachi, 306-0433, Japan|39200031 - Kurosawa Hospital, Takasaki-Shi, 370-1203, Japan|39200034 - Kikuchi Medical Clinic, Tsukuba-shi, 305-0861, Japan|39200030 - St.Hill Hospital, Ube-shi, 755-0155, Japan|39200051 - Bosei Kannai Clinic, Yokohama-shi, 231-0048, Japan|39200036 - Sanin Rosai Hospital, Yonago-shi, 683-8605, Japan|41000002 - SMG - SNU Boramae Medical Center, Ilsan-gu, Seoul, 7061, Korea, Republic of|41000006 - Hallym University Sacred Heart Hospital, Anyang-si, 14068, Korea, Republic of|41000004 - Keimyung University Dongsan Medical Center, Daegu, 42601, Korea, Republic of|41000001 - Gangnam Severance Hospital, Gangnam-gu, 6273, Korea, Republic of|41000009 - National Health Insurance Service - Ilsan Hospital, Goyang-si, 10444, Korea, Republic of|41000008 - Konkuk University Medical Center, Gwangju, 5030, Korea, Republic of|41000005 - Seoul National University Hospital, Seoul, 03080, Korea, Republic of|41000012 - Severance Hospital, Yonsei University, Seoul, 03722, Korea, Republic of|41000007 - Yonsei University - Wonju Severance Christian Hospital, Wonju-si, 26426, Korea, Republic of|62000011 - Unidade Local de Saúde de Braga, E. P. E., Braga, 4710-243, Portugal|62000009 - Unidade Local de Saúde de São José, E. P. E., Oeiras, 2790, Portugal|62000005 - Unidade Local de Saúde de Santo António, E. P. E., Porto, 4099-001, Portugal|64200014 - SC International Healthcare Systems SA - IHS Sf. Ioan Dialysis Center, Bucharest, 042122, Romania|64200024 - Fundeni Clinical Institute, Bucuresti, 22328, Romania|64200016 - Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta (Emergency Clinic Hospital Constanta), Constanta, 900591, Romania|64200005 - Spital Judetean de Urgenta Satu Mare, Satu Mare, 440055, Romania|75200001 - Uppsala Universitet - Akademiska Sjukhuset, Uppsala, 75185, Sweden|82600027 - Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, United Kingdom|82600023 - University Hospital Coventry and Warwickshire, Coventry, CV2 2DX, United Kingdom|82600024 - Royal Liverpool University Hospital, Liverpool, L7 8XP, United Kingdom|82600028 - Altnagelvin Area Hospital, Londonderry, BT47 6SB, United Kingdom|82600034 - St George's University Hospitals NHS Foundation Trust - St G, London, SW17 0QT, United Kingdom|82600025 - Royal Stoke University Hospital, Stoke-on-Trent, ST4 6QG, United Kingdom
URL: https://clinicaltrials.gov/show/NCT05485961

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress