| Outcome Measures: |
Primary: Change in liver fat content（%） measured by MRS, Change in liver fat content（%） measured by MRS, baseline and 24 weeks | Secondary: Change in intra-abdominal visceral fat content (cm2), abdominal subcutaneous fat content (cm2), and ratio between intra-abdominal visceral fat and subcutaneous fat area by MRI, Change in intra-abdominal visceral fat content (cm2), abdominal subcutaneous fat content (cm2), and ratio between intra-abdominal visceral fat and subcutaneous fat area by MRI, baseline and 24 weeks|Change in glucose metabolism (fasting blood glucose, postprandial plasma glucose, HbA1c), Change in glucose metabolism (fasting blood glucose, postprandial plasma glucose, HbA1c), baseline and 24 weeks|Change in blood lipid profile (total cholesterol, triglyceride, HDL, LDL), Change in blood lipid profile (total cholesterol, triglyceride, HDL, LDL), baseline and 24 weeks|Change in body weight,waist circumference and hip circumference, Change in body weight,waist circumference and hip circumference, baseline and 24 weeks | Other: Change in cardiac function measured by echocardiography, Change in cardiac function measured by echocardiography, baseline and 24 weeks|Change in β-cell function (fasting C-peptide, 2-hour postprandial C-peptide), Change in β-cell function (fasting C-peptide, 2-hour postprandial C-peptide), baseline and 24 weeks|Change in liver enzymes and laboratory parameters (hematology, biochemical tests), Change in liver enzymes and laboratory parameters (hematology, biochemical tests), baseline and 24 weeks|Incidence of hypoglycaemia events, Incidence of hypoglycaemia events, up to 24 weeks|Incidence of adverse events（AEs）and Severe adverse events(SAEs), Incidence of adverse events（AEs）and Severe adverse events(SAEs), up to 24 weeks
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| Locations: |
Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, Shanghai, 200032, China|Department of Endocrinology and Metabolism, Shanghai Minhang Central Hospital, Shanghai, Shanghai, China|Department of Endocrinology and Metabolism,Huadong Hospital, Shanghai, Shanghai, China|Department of Endocrinology and Metabolism,Shanghai 6th People's Hospital, Shanghai, Shanghai, China|Department of Endocrinology and Metabolism,Shanghai Changzheng Hospital, Shanghai, Shanghai, China
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