| Trial ID: | L1981 |
| Source ID: | NCT05264727
|
| Associated Drug: |
Dextrose
|
| Title: |
Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion
|
| Acronym: |
|
| Status: |
RECRUITING
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Healthy|Type 2 Diabetes|Obesity
|
| Interventions: |
DRUG: Dextrose|DRUG: Clinisol 15%
|
| Outcome Measures: |
Primary: Change in Glucagon Suppression (G50) caused by amino acids vs. saline, concentration of glucose necessary to suppress glucagon by 50%, 240 minutes of study | Secondary: Glucagon suppression (G50) is greater in people with T2DM, concentration of glucose necessary to suppress glucagon by 50%, 240 minutes of study|glucagon suppression (G50) is greater in obese compared to lean people without T2DM, concentration of glucose necessary to suppress glucagon by 50%, 240 minutes of study
|
| Sponsor/Collaborators: |
Sponsor: Mayo Clinic | Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
60
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2023-05-30
|
| Completion Date: |
2025-12-31
|
| Results First Posted: |
|
| Last Update Posted: |
2024-05-29
|
| Locations: |
Mayo Clinic Rochester, Rochester, Minnesota, 55905, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT05264727
|
