| Trial ID: | L1990 |
| Source ID: | NCT03081676
|
| Associated Drug: |
Glimepiride 1mg Tablet
|
| Title: |
The Effect of GIP and GLP-1 on Insulin and Glucagon Secretion in Patients With HNF1A-diabetes Treated With or Without Sulphonylurea
|
| Acronym: |
HNF1A-Clamp
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Maturity-Onset Diabetes of the Young, Type 3
|
| Interventions: |
DRUG: Glimepiride 1Mg Tablet|DRUG: Glucagon-like Peptide-1|DRUG: Glucose-Dependent Insulinotropic Polypeptide|DRUG: Placebo Oral Tablet|DRUG: Placebo infusion
|
| Outcome Measures: |
Primary: Insulin secretion, Incremental area under the curve (iAUC) for insulin (measured as C-peptide) at time 0-60 minutes, time 60-120 minutes and time 0-120 minutes, 0-120 minutes | Secondary: Glucagon secretion, Incremental area under the curve (iAUC) for plasma glucagon at time 0-60 minutes, time 60-120 minutes and time 0-120 minutes, 0-120 minutes|Maximal insulin secretion, Arginine maximal insulin secretion test., 120-125 minutes|Maximal glucagon secretion, Arginine maximal glucagon secretion test., 120-125 minutes|Amount glucose used to maintain the glucose clamp, 0-120 minutes
|
| Sponsor/Collaborators: |
Sponsor: University Hospital, Gentofte, Copenhagen
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
20
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2017-03-08
|
| Completion Date: |
2018-06-01
|
| Results First Posted: |
|
| Last Update Posted: |
2019-06-27
|
| Locations: |
Center for Diabetes Research, Gentofte Hospital, Hellerup, 2900, Denmark
|
| URL: |
https://clinicaltrials.gov/show/NCT03081676
|
