| Trial ID: | L2005 |
| Source ID: | NCT06606327
|
| Associated Drug: |
Diazoxide, 3 Mg/Kg Per Dose
|
| Title: |
Diazoxide Suppression Test P&F Study
|
| Acronym: |
DzST
|
| Status: |
RECRUITING
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Insulin Resistance|Hyperinsulinemia|Obesity
|
| Interventions: |
DRUG: Diazoxide, 3 mg/kg per dose
|
| Outcome Measures: |
Primary: Fasting plasma glucose, Plasma glucose level after overnight fast (units: mg/dL), Baseline and after 4 days of diazoxide treatment|Fasting serum insulin, Serum insulin level after overnight fast (units: µU/mL), Baseline and after 4 days of diazoxide treatment | Secondary: Fasting serum C-peptide, Serum C-peptide level after overnight fast (units: ng/mL), Baseline and after 4 days of diazoxide treatment|Fasting serum triglyceride, Serum triglyceride level after overnight fast (units: mg/dL), Baseline and after 4 days of diazoxide treatment|Fasting plasma free fatty acids (FFA), FFA level after overnight fast (units: mmol/L), Baseline and after 4 days of diazoxide treatment
|
| Sponsor/Collaborators: |
Sponsor: Columbia University | Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of Pisa
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE1
|
| Enrollment: |
10
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2024-10-23
|
| Completion Date: |
2026-01
|
| Results First Posted: |
|
| Last Update Posted: |
2025-01-08
|
| Locations: |
Columbia University Irving Medical Center, New York, New York, 10032, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT06606327
|
