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Clinical Trial Details

Trial ID: L2108
Source ID: NCT05214573
Associated Drug: Glucagon Like Peptide 1 Receptor Agonist
Title: Second-line Therapies for Patients with Type 2 Diabetes and Moderate Cardiovascular Disease Risk
Acronym:
Status: ACTIVE_NOT_RECRUITING
Study Results: NO
Results:
Conditions: Type 2 Diabetes|Cardiac Disease
Interventions: DRUG: Glucagon like peptide 1 receptor agonist|DRUG: Sodium-glucose cotransporter 2 inhibitor|DRUG: Dipeptidyl Peptidase 4 Inhibitor|DRUG: Sulfonylurea
Outcome Measures: Primary: 3-point MACE, Number of 3-point MACE events defined as non-fatal MI, non-fatal stroke, and mortality, 1/1/2014 - 12/31/2021 | Secondary: Expanded MACE and its components, Number of 3-point MACE (non-fatal MI, non-fatal stroke, mortality) plus heart failure hospitalization and revascularization procedure events, 1/1/2014 - 12/31/2021|Non-fatal myocardial infarction (MI), Number of non-fatal myocardial infarctions, 1/1/2014 - 12/31/2021|Non-fatal stroke events, Number of non-fatal stroke events, 1/1/2014 - 12/31/2021|All-cause moratality, Number of deaths, 1/1/2014 - 12/31/2021|Severe hypoglycemia, Number of emergency department visits or hospitalization for hypoglycemia, 1/1/2014 - 12/31/2021|Incident end-stage kidney disease, Number of initiation of dialysis or new diagnosis of stage 5 or end-stage kidney disease, 1/1/2014 - 12/31/2021|Treatment for diabetic retinopathy or macular edema, Number of treatments for diabetic retinopathy or macular edema, 1/1/2014 - 12/31/2021|Lower extremity complications, Number of foot and/or leg amputation, osteomyelitis, ulcer, Charcot arthropathy, 1/1/2014 - 12/31/2021
Sponsor/Collaborators: Sponsor: Mayo Clinic | Collaborators: Patient-Centered Outcomes Research Institute
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases:
Enrollment: 5e+05
Study Type: OBSERVATIONAL
Study Designs: Observational Model: |Time Perspective: p
Start Date: 2021-12-01
Completion Date: 2025-10-31
Results First Posted:
Last Update Posted: 2024-10-16
Locations: Mayo Clinic Rochester, Rochester, Minnesota, 55905, United States
URL: https://clinicaltrials.gov/show/NCT05214573