| Trial ID: | L2461 |
| Source ID: | NCT01690091
|
| Associated Drug: |
Metformini Hydrochloridum (Siofor 1000 Tbl, Berlin)
|
| Title: |
Cardioprotective and Metabolic Effects of Metformin in Patients With Heart Failure and Diabetes
|
| Acronym: |
CARMET
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Insulin Resistance|Chronic Heart Failure
|
| Interventions: |
DRUG: Metformini hydrochloridum (Siofor 1000 tbl, Berlin)|DRUG: placebo
|
| Outcome Measures: |
Primary: insulin sensitivity, change of glucose disposal during clamp, at baseline and after 3 months | Secondary: energy expenditure, change of energy expenditure measured by indirect calorimetry, at baseline and after 3 months|endothelial function, change in digital pulse amplitude tonometry, at baseline and after 3 months|heart function, change measured by echocardiography and spiroergometry, at baseline and after 3 months
|
| Sponsor/Collaborators: |
Sponsor: Institute for Clinical and Experimental Medicine
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE2|PHASE3
|
| Enrollment: |
40
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
|
| Start Date: |
2012-11
|
| Completion Date: |
2016-12
|
| Results First Posted: |
|
| Last Update Posted: |
2018-03-29
|
| Locations: |
Diabetes Center, Institute of Clinical and Experimental Medicine, Prague, Czechia
|
| URL: |
https://clinicaltrials.gov/show/NCT01690091
|
