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Clinical Trial Details

Trial ID: L2536
Source ID: NCT02324010
Associated Drug: Sitagliptin
Title: Effects of Sitagliptin on Gastric Emptying, Glycaemia and Blood Pressure in Type 2 Diabetes
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: Gastroparesis|Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Placebo
Outcome Measures: Primary: Gastric emptying, Gastric retention (percent in the total stomach), 3 hours per gastric emptying study (i.e. 6 hours) | Secondary: Glycaemia, blood glucose (mmol/L) and plasma insulin (mU/L), 4 hours during each gastric empty study (i.e. 8 hours)|Gastrointestinal hormone release, GLP-1, GIP, C-peptide, 3-OMG, 4 hours during each gastric empty study (i.e. 8 hours)|Intragastric meal distribution, percent retention in the proximal and distal stomach, 3 hours during each gastric empty study (i.e. 6 hours)|Blood pressure, systolic and diastolic blood pressure (mmHg), 4.5 hours during each gastric empty study (i.e. 9 hours)|Heart rate, Heart rate (beats per minute), 4.5 hours during each gastric empty study (i.e. 9 hours)|Splanchnic blood flow, Doppler ultrasound of superior mesenteric artery flow (ml/min), 4 hours during each gastric empty study (i.e. 8 hours)|Cardiac output, Finapres (L), 4 hours during each gastric empty study (i.e. 8 hours)|Stroke volume, Finapres (mL), 4 hours during each gastric empty study (i.e. 8 hours)|Appetite, visual analogue questionnaire to assess hunger, fullness, desire to eat (mm), 4 hours during each gastric empty study (i.e. 8 hours)
Sponsor/Collaborators: Sponsor: Royal Adelaide Hospital
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE2
Enrollment: 14
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Start Date: 2015-07
Completion Date: 2017-01
Results First Posted:
Last Update Posted: 2017-07-07
Locations: University of Adelaide, Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia
URL: https://clinicaltrials.gov/show/NCT02324010