| Trial ID: | L0255 |
| Source ID: | NCT03982160
|
| Associated Drug: |
L-Arginine
|
| Title: |
L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients
|
| Acronym: |
|
| Status: |
RECRUITING
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Chronic Kidney Disease
|
| Interventions: |
DRUG: L-Arginine|OTHER: Placebo
|
| Outcome Measures: |
Primary: Muscle sympathetic nerve activity (MSNA) will be reduced after L-arginine infusion, Multiunit postganglionic MSNA will be recorded using standard microneurographic techniques. Briefly, a unipolar tungsten microelectrode will be inserted into muscle fascicles of the peroneal nerve near the fibular head of the right leg. Neural signals will be amplified, filtered (bandwidth, 700-2,000 Hz), rectified, and integrated (time constant, 0.1 s) to obtain mean voltage neurograms (University of Iowa Bioengineering, Iowa City, IA)., 30 minutes |
|
| Sponsor/Collaborators: |
Sponsor: The University of Texas at Arlington
|
| Gender: |
ALL
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| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
15
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2018-02-01
|
| Completion Date: |
2026-12-31
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| Results First Posted: |
|
| Last Update Posted: |
2025-03-03
|
| Locations: |
University of Delaware, Newark, Delaware, 19716, United States|UT Southwestern, Dallas, Texas, 75390, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT03982160
|
